A5049214550- Parkinson's Disease Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Medicinal Plants and Neuroprotection
- Alzheimer's disease research and treatments
- Neuroscience and Neuropharmacology Research
- Ginger and Zingiberaceae research
- Biochemical Analysis and Sensing Techniques
- Nerve injury and regeneration
- Genomics, phytochemicals, and oxidative stress
- Nuclear Receptors and Signaling
- Magnolia and Illicium research
- Tryptophan and brain disorders
- Nephrotoxicity and Medicinal Plants
- Plant Toxicity and Pharmacological Properties
- Cholinesterase and Neurodegenerative Diseases
- Stress Responses and Cortisol
- Neurogenesis and neuroplasticity mechanisms
- Advanced biosensing and bioanalysis techniques
- Dysphagia Assessment and Management
- Ginkgo biloba and Cashew Applications
- Biochemical effects in animals
- Pharmacological Effects of Natural Compounds
- Adipose Tissue and Metabolism
- Supramolecular Self-Assembly in Materials
- Gut microbiota and health
Kyung Hee University
2016-2025
Gachon University
2024-2025
Government of the Republic of Korea
2017-2020
Dunsan Korean Medicine Hospital
2020
Graduate School USA
2017-2020
Oxidative stress plays a key role in neurodegenerative diseases such as Alzheimer's and Parkinson's diseases. Therefore, the nuclear factor-E2-related factor 2 (Nrf2), regulator of antioxidative response, is considered to be important therapeutic target for We investigated underlying mechanism Nrf2-mediated neuroprotective effects against oxidative PC12 cell line by 7β-(3-ethyl-cis-crotonoyloxy)-1α-(2-methylbutyryloxy)-3,14-dehydro-Z-notonipetranone (ECN), one sesquiterpenoids Farfarae Flos....
Acetylcholinesterase (AChE) is an extremely critical hydrolase tightly associated with neurological diseases. Currently, developing specific substrates for imaging AChE activity still remains a great challenge due to the interference from butyrylcholinesterase (BChE) and carboxylesterase (CE). Herein, we propose approach designing detection by combining dimethylcarbamate choline self-immolative scaffold. The representative P10 can effectively eliminate CE BChE. high specificity of has been...
A new glioblastoma (GBM) targeting peptide is developed and successfully demonstrated the delivery of a nano-therapeutic.
A fluorescent molecular probe for the identification of glioblastoma is developed. The allows tracing cysteine (Cys) level, which recognized as a new biomarker GBM.
Abstract Parkinson’s disease (PD) is a complex progressive neurodegenerative characterized by both motor and nonmotor symptoms such as constipation dyspepsia. Recently, growing evidence has suggested that specific gut microbiome associated with the pathophysiology of PD through microbiota-gut-brain axis. We previously discovered Proteus mirabilis induced impairment brain dopaminergic neurodegeneration in normal mice. In this context, exploring beneficial microbe would be reasonable strategy...
Ginger, which has been widely used for dietary condiment, reported to improve memory dysfunction in an animal model of Alzheimer's disease (AD). Recently, a few trials have carried out enhance the effects ginger by improving bioavailability its relevant components via fermentation. Some reports suggested that fermented ability affect AD vitro systems; however, anti-amnesic on vivo still remain be investigated. In present study, we aimed investigate neuroprotective with Schizosaccharomyces...
Parkinson's disease (PD) which has various pathological mechanisms, recently, it is attracting attention to the mechanism via microbiome-gut-brain axis. 6-Shogaol, a representative compound of ginger, have been known for improving PD phenotypes by reducing neuroinflammatory responses. In present study, we investigated whether 6-shogaol and ginger attenuate degeneration induced Proteus mirabilis (P. mirabilis) on intestine brain, simultaneously. C57BL/6J mice received P. 5 days. Ginger (300...
Heat stress conditions lead to neuroinflammation, neuronal death, and memory loss in animals. Coptidis Rhizoma (CR) exhibits potent fever-reducing effects has been used as an important traditional medicinal herb for treating fever. However, date, the of antipyretic CR on heat-induced brain damages have not investigated. In this study, significantly reduced elevation ear rectal temperatures after exposure heat mice. Additionally, attenuated hyperthermia-induced responses, such release...
Ultraviolet (UV) light, a major risk factor for external skin photoaging, induces oxidative stress in skin. UV causes breakdown of homeostasis by impairing the extracellular matrix and inducing cell death. Tectorigenin, constituent leopard lily (Belamcanda chinensis L.) rhizome, has been reported to possess antioxidant, hair-darkening, anti-inflammatory activities; however, effect tectorigenin on UV-B-induced damage is unknown. Here, we investigated anti-skin-damage effects against...
Long-term administration of levodopa (L-DOPA) to patients with Parkinson's disease (PD) commonly results in involuntary dyskinetic movements, as is known for L-DOPA-induced dyskinesia (LID). 5-Hydroxytryptophan (5-HTP) has recently been shown alleviate LID; however, no biochemical alterations aberrant excitatory conditions have revealed yet. In the present study, we aimed confirm its anti-dyskinetic effect and discover unknown molecular mechanisms action 5-HTP LID. We made an LID-induced...
The present study aimed to investigate the effect of 6-shogaol (6S) treatment on brain senescence. Mice were naturally aged until 25-month-old and treated with 10 mg/kg 6S for a month. Behavioral tests performed measure locomotion cognitive function. Neuronal damage, synaptic plasticity, neuroinflammation, neurogenesis p75 neurotrophin receptor (p75NTR) expression examined by immunohistochemistry or immunofluorescence. improved during open field test in mice spontaneous alternation Y-maze....
Alzheimer's disease (AD) is the most common neurodegenerative characterized by amyloid-β (Aβ) deposition, accompanied neuroinflammation and memory dysfunction. Houttuyniae Herba (aerial parts of Houttuynia cordata, also known as fish mint; HH), an herbal medicine traditionally used to treat fever, urinary disorders, pus, revealed protect neurons from Aβ toxicity regulate cholinergic dysfunction in AD models. In this study, we aimed investigate effects HH on excessive accumulation followed...
Objective: Ginger and its compound, 6-shogaol, have been known for improving gastrointestinal (GI) function reducing inflammatory responses in GI tract. Recently, the treatment of dysfunction has recognized as an important part management neurodegenerative diseases, especially Parkinson's disease (PD). In this study, we investigated whether ginger 6-shogaol attenuate disruptions induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on intestinal barrier enteric dopaminergic...
Amyloid-beta oligomer (AβO) is a soluble form of the Aβ peptide and most potent amyloid-beta that induces neuronal damage in Alzheimer's disease. We investigated effect dried white ginseng extract (WGE) on cell memory impairment intrahippocampal AβO (10 μM)-injected mice. Mice were treated with WGE (100 500 mg/kg/day, p.o.) for 12 days after surgery. improved by inhibiting hippocampal death caused AβO. In addition, AβO-injected mice showed restoration reduced synaptophysin choline...
Cognitive impairment is a result of dementia diverse causes, such as cholinergic dysfunction and Alzheimer's disease (AD).Houttuynia cordata Thunb.(Saururaceae) has long been used traditional herbal medicine.It biological activities including protective effects against amyloid beta (Ab) toxicity, via regulation calcium homeostasis, in rat hippocampal cells.To extend previous reports, we investigated the water extracts H. herb (HCW) on tauopathies, also involving influx.We then confirmed HCW...
Neuroinflammation causes various neurological disorders, including depression and neurodegenerative diseases. Therefore, regulation of neuroinflammation is a promising therapeutic strategy for inflammation-related disorders. This study aimed to investigate whether yomogin, isolated from Artemisia iwayomogi, has anti-neuroinflammatory effects. First, we evaluated the effects yomogin by assessing pro-inflammatory mediators cytokines in lipopolysaccharide (LPS)-stimulated BV2 microglial cells....
Recent studies suggesting the importance of gut-microbiome in intestinal aggregated alpha synuclein (α-syn) have led to exploration possible role gut-brain axis central nervous system degeneration. Proteus mirabilis (P. mirabilis), a gram-negative facultative anaerobic bacterium, has been linked brain neurodegeneration animal studies. We hypothesised that P. mirabilis-derived virulence factors aggregate α-synuclein and could prompt pathogenesis dopaminergic brain.
Recently, there has been a rapid increase in studies on the relationship between brain diseases and gut microbiota, clinical evidence microbial changes Parkinson's disease (PD) accumulated. 6-Hydroxydopamine (6-OHDA) is widely used neurotoxin that leads to PD pathogenesis, but whether 6-OHDA affects environment not investigated. Here we performed 16S rRNA gene sequencing analyze community of mice. We found were no significant species richness its diversity 6-OHDA-lesioned The relative...
With the elderly population rapidly growing, prevalence of Parkinson's disease (PD) is quickly increasing because neurodegenerative disorders are usually late-onset. Herbal medicines and formula adjuvant therapies conventional PD agents, which result in serious side effects with long-term use. This study evaluated neuroprotective DA-9805, a standardized herbal that consists an ethanolic extract Moutan Cortex Radix, Angelica Dahuricae Bupleuri Radix against 6-hydroxydopamine (6-OHDA)-induced...
Alzheimer's disease (AD) is the most common dementia characterized by excessive accumulation of amyloid-beta (Aβ) and tau aggregates, as well neuronal damage neuroinflammation. Metabolic disruption in AD has been noticed because metabolite alterations closely correlate with Aβ neuropathology behavioral phenotypes. Accordingly, controlling various neuropathological processes metabolic an efficient therapeutic strategy for treatment. In this study, we evaluated effects a combination Cuscuta...