A5017319680- Inflammasome and immune disorders
- Dermatology and Skin Diseases
- Gout, Hyperuricemia, Uric Acid
- Allergic Rhinitis and Sensitization
- Immune Response and Inflammation
- Liver Disease Diagnosis and Treatment
- Natural product bioactivities and synthesis
- Adipokines, Inflammation, and Metabolic Diseases
- Pharmacological Effects of Natural Compounds
- Herbal Medicine Research Studies
- Cholesterol and Lipid Metabolism
- Peroxisome Proliferator-Activated Receptors
- Phytochemistry and Biological Activities
- Urticaria and Related Conditions
- Contact Dermatitis and Allergies
- Neurological Disease Mechanisms and Treatments
- Autophagy in Disease and Therapy
- Immune Cell Function and Interaction
- Asthma and respiratory diseases
- Alzheimer's disease research and treatments
- Diet, Metabolism, and Disease
- Berberine and alkaloids research
- Plant chemical constituents analysis
- Autoimmune and Inflammatory Disorders Research
- Natural Antidiabetic Agents Studies
Woosuk University
2020-2025
Catholic University of Korea
2015-2023
Sangji University
2012-2019
Bucheon St. Mary's Hospital
2017-2018
Kyung Hee University
2008-2015
Northwest A&F University
2008
Abstract The activation of NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome is closely associated with the development and progression non-alcoholic fatty liver disease (NAFLD) induced by a high-fat diet. Therefore, we investigated whether oral administration sulforaphane (SFN) prevented diet-induced NAFLD in mice regulation NLRP3 liver. Daily administrations SFN reduced hepatic steatosis scores, serum ALT AST levels, levels cholesterol, triglycerides, free acids fed...
Abstract Gouty arthritis is caused by the deposition of uric acid crystals, which induce activation NOD-like receptor family, pyrin domain containing 3(NLRP3) inflammasome. The NLRP3 inflammasome, composed NLRP3, adaptor protein ASC, and caspase-1, closely linked to pathogenesis various metabolic diseases including gouty arthritis. We investigated whether an orally administrable inhibitor inflammasome was effective for alleviating pathological symptoms what underlying mechanism. In primary...
Tumor microenvironment favors tumor cells to promote their growth and metastasis such as migration, invasion, angiogenesis. IL-1β, one of the inflammatory cytokines released from myeloid in microenvironment, plays an important role development progress tumor. The activation inflammasome is a critical step secrete mature IL-1β through stepwise reactions activate capspase-1. Therefore, we investigated whether inhibition NACHT, LRR PYD domains-containing protein 3 (NLRP3) macrophages regulated...
Objective The NLRP 3 inflammasome is closely linked to the pathophysiology of a wide range inflammatory diseases. This study was undertaken identify small molecules that directly bind in order develop pharmacologic interventions for 3‐related Methods A structure‐based virtual screening analysis performed with ~62,800 compounds select efficient inhibitors. production caspase 1‐p10 and interleukin‐1β ( IL ‐1β) measured by immunoblotting enzyme‐linked immunosorbent assay examine activation. Two...
Abstract The NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome is a multiprotein complex consisting of receptor, an adaptor protein, and procaspase-1 that induces the secretion mature form IL-1β in response to microbial infection danger signals. Activation NLRP3 induced by endogenous signal molecules closely linked development progress chronic inflammatory diseases. oxidation phospholipids occurs upon cellular stress damage, resulting accumulation oxidized...
The aetiology of gout is closely linked to the deposition monosodium uric acid (MSU) crystals and consequent activation NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome. In this study, we investigated whether oral administration an NLRP3 inhibitor would be effective attenuate symptoms gout. effects with sulforaphane (SFN) were examined in two mouse models acute induced by injection MSU into footpads or air pouch. production caspase-1 (p10) IL-1β was immunoblotting...
Gout is a chronic inflammatory disease evoked by the deposition of monosodium urate (MSU) crystals in joint tissues. The nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family pyrin containing 3 (NLRP3) inflammasome responsible for gout symptoms induced MSU crystals. We investigated whether epigallocatechin-3-gallate (EGCG) suppresses activation NLRP3 inflammasome, thereby effectively preventing gouty inflammation. EGCG blocked crystal-induced production caspase-1(p10)...
Non-alcoholic steatohepatitis (NASH), a type of non-alcoholic fatty liver disease, is characterized as steatosis and inflammation in the liver. NLRP3 inflammasome activation associated with NASH pathology. We hypothesized that suppressing could be effective preventing NASH. searched substances inhibit identified sweroside an inhibitor. investigated whether can applied to prevent pathological symptoms methionine–choline-deficient (MCD) diet-induced mouse model. The was determined by detecting...
Cudrania tricuspidata extract is an important traditional herbal remedy for tumors, inflammation, gastritis, and liver damage predominantly used in Korea, China, Japan. However, the anti-inflammatory effects of have not yet been conclusively proved.In this study, we investigated CHCl3 fraction (CTC) a methanol C. on lipopolysaccharide (LPS)-induced nitric oxide (NO) prostaglandin E2 (PGE2) production RAW 264.7 macrophage cells mouse peritoneal macrophages, levels pro-inflammatory cytokines...
Activation of the NACHT, LRR and PYD domains‐containing protein 3 (NLRP3) inflammasome by Propionibacterium acnes ( P . ) is critical for inducing inflammation aggravating development acne lesions. We searched available small‐molecule inhibitors NLRP3 that could be topically administered treatment acne. found licochalcone A, a chalconoid isolated from root Glycyrrhiza inflate , was an effective inhibitor ‐induced activation. Licochalcone A blocked acnes‐ induced production caspase‐1(p10)...
Gout is a type of inflammatory arthritis caused by the deposition monosodium uric acid (MSU) crystals in tissues. The etiology gout directly linked to NLRP3 inflammasome, since MSU are inflammasome activators. Therefore, we decided search for small-molecule inhibitor prevention inflammation. We found that loganin suppressed crystals-induced caspase-1 (p20) and interleukin (IL)-1β production apoptosis-associated speck-like protein containing caspase recruitment domain (ASC) specks formation...
<title>Abstract</title> This study aimed to investigate the pharmacokinetics and acute toxicity of a single intravenous dose distilled Zanthoxylum piperitum (deZP) extract in ICR mice. The focus was on understanding absorption, distribution, elimination Terpinen-4-ol, major active component deZP, as well assessing its safety at administered dose. mice were deZP (2.4 mg/kg), plasma concentrations Terpinen-4-ol measured using LC-MS/MS various time points. Pharmacokinetic parameters such Cmax,...
Psoriasis is a chronic inflammatory skin disease characterized by an immune system response, manifesting in various forms including plaques, flexural lesions, wounds, pustules, and erythroderma. This condition affects individuals of all genders impacts approximately 60 million people worldwide. The pathophysiology psoriasis involves complex interactions between keratinocytes, dendritic cells, T with the IL-23/Th17 axis playing crucial role keratinocyte proliferation, inflammation,...
Aster glehni (AG) is a Korean traditional herb that grows in Ulleungdo Island, Republic of Korea. None the several reports on AG include determination effect adipogenesis. The primary aim this study was to determine whether attenuates adipogenesis mouse 3T3-L1 cells and epididymal fat tissue. blocked differentiation preadipocytes concentration-dependent manner suppressed expression adipogenesis-related genes such as PPAR γ , C/EBP α SREBP1c master regulators Male C57BL/6J mice were divided...
Astragalus membranaceus (AM) is one of the most popular health-promoting herbs in East Asia, and has been used traditional medicine for more than 2000 years. This study was performed to examine whether AM suppresses atopic dermatitis (AD)-like skin lesions BALB/c mice. Seven-week-old female mice were sensitized with 1-chloro-2,4-dinitrobenzene (DNCB) induce allergic dermatitis. Skin sections stained hematoxylin eosin (H&E) assess epidermal dermal hyperplasia, which determined by measuring...