A5103279457- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Autoimmune and Inflammatory Disorders Research
- Systemic Sclerosis and Related Diseases
- Cytokine Signaling Pathways and Interactions
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Immune Cell Function and Interaction
- Inflammatory mediators and NSAID effects
- Osteoarthritis Treatment and Mechanisms
- Psoriasis: Treatment and Pathogenesis
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Immunodeficiency and Autoimmune Disorders
- Spondyloarthritis Studies and Treatments
- Pharmacological Effects of Natural Compounds
- NF-κB Signaling Pathways
- Skin Diseases and Diabetes
- Hematopoietic Stem Cell Transplantation
- Salivary Gland Disorders and Functions
- Renal Diseases and Glomerulopathies
- Sarcoidosis and Beryllium Toxicity Research
- Monoclonal and Polyclonal Antibodies Research
- Mast cells and histamine
- Bone and Joint Diseases
- Gout, Hyperuricemia, Uric Acid
Catholic University of Korea
2016-2025
Yeouido St. Mary's Hospital
2022-2025
University of Ulsan
2020-2024
Asan Medical Center
2020-2024
Ulsan College
2020-2024
Brigham and Women's Hospital
2023
Harvard University
2023
Uijeongbu St. Mary's Hospital
2019-2022
Seoul St. Mary's Hospital
2010-2021
Dankook University
2021
Abstract Fibroblast-like synoviocytes (FLSs) are a major cell population of the pannus that invades cartilage and bone in rheumatoid arthritis (RA). FLS resistance to apoptosis is characteristic RA. The aims this study were investigate effects interleukin-17 (IL-17) IL-17-producing T helper (Th17) cells on FLSs from RA patients (RA FLSs) their roles mitochondrial dysfunction autophagy. Mitochondrial function was assessed osteoarthritis (OA FLSs). treated with IL-17 morphological features,...
Abstract Circulating autoantibodies and immune complex deposition are pathological hallmarks of systemic lupus erythematosus (SLE). B cell differentiation into plasma cells (PCs) some T subsets that function as helpers can be therapeutic targets SLE. Mechanistic target rapamycin (mTOR) signaling is implicated in the formation germinal centers (GCs). We assessed effect metformin, which inhibits mTOR, on development autoimmunity using Roquinsan/san mice. Oral administration metformin inhibited...
Objective The NLRP 3 inflammasome is closely linked to the pathophysiology of a wide range inflammatory diseases. This study was undertaken identify small molecules that directly bind in order develop pharmacologic interventions for 3‐related Methods A structure‐based virtual screening analysis performed with ~62,800 compounds select efficient inhibitors. production caspase 1‐p10 and interleukin‐1β ( IL ‐1β) measured by immunoblotting enzyme‐linked immunosorbent assay examine activation. Two...
The interleukin-33 (IL-33)/ST2 pathway has emerged as an intercellular signaling system that participates in antigen-allergen response, autoimmunity and fibrosis. It been suggested IL-33/ST2 involved the pathogenesis of rheumatoid arthritis (RA), because IL-33 its receptor have specifically mapped to RA synovium. aim this study was determine levels sST2 sera synovial fluids patients with RA. serum level significantly higher (294.9 ± 464.0 pg/mL) than healthy controls (96.0 236.9 pg/mL, P =...
Objective: Systemic sclerosis (SSc) is a progressive fibrotic disease that affects the skin and internal organs. Despite evidence implicating increased interleukin-17 (IL-17) activity in SSc, role of IL-17 SSc remains uncertain. The purpose this study was to investigate whether plays pathophysiological two different murine models SSc. Methods: Bleomycin (BLM)-induced fibrosis chronic graft-versus-host (cGVHD) were used. Histological analysis performed using Masson's trichrome...
Interleukin 34 (IL-34) is a recently discovered cytokine that binds macrophage colony-stimulating factor (M-CSF) receptor. Rheumatoid arthritis (RA) characterized by increased osteoclastogenesis. To identify the significance of IL-34 in RA, concentration was measured serum and synovial fluid (SF).IL-34 concentrations were from patients with RA (n = 113), osteoarthritis (OA; n 56), controls 36), SF isolated 36) or OA 24). Correlations between levels clinical features assessed. The IL-1β,...
Interleukin (IL)-27 is a novel cytokine of the IL-6/IL-12 family that has been reported to be involved in pathogenesis autoimmune diseases and pivotal role as both pro- anti-inflammatory cytokine. We investigated vivo effects IL-27 on arthritis severity murine collagen-induced (CIA) model its mechanism action regarding control regulatory T (Tregs) IL-17-producing helper 17 (Th17) cells. IL-27-Fc-treated CIA mice showed lower arthritis. IL-17 expression spleens was significantly decreased...
Abstract Rheumatoid arthritis (RA) is a systemic inflammatory disease that mainly affects the synovial joints. Although involvement of fibroblast growth factor (FGF) signaling pathway has been suggested as an important modulator in RA development, no clear evidence provided. In this study, we found fluid basic FGF (bFGF) concentration was significantly higher than osteoarthritis (OA) patients. bFGF stimulates proliferation and migration human fibroblast-like synoviocytes (FLSs) by activation...
Mesenchymal stem cells (MSCs) can protect against cartilage breakdown in osteoarthritis (OA) via their immunomodulatory capacities. However, the optimization strategy for using MSCs remains challenging. This study's objective was to identify vivo effects of metformin-stimulated adipose tissue-derived human (Ad-hMSCs) OA. An animal model OA established by intra-articular injection monosodium iodoacetate into rats. rats were divided a control group and two therapy groups (treated with Ad-hMSCs...
Epoxyeicosatrienoic acids (EETs) are metabolites of arachidonic acid that rapidly metabolized into diols by soluble epoxide hydrolase (sEH). sEH inhibition has been shown to increase the biological activity EETs, which known have anti-inflammatory properties. However, role EETs in pulmonary fibrosis remains unexplored. Liquid chromatography with tandem mass spectrometry (LC-MS/MS) was used analyze lung tissues patients idiopathic (IPF, n = 29) and controls (n 15), function 11,12-EET...
Abstract Objective To investigate the impact of STAT‐3–mediated regulation on Th17 differentiation in patients with rheumatoid arthritis (RA). Methods CD4+ T cells isolated from peripheral blood (PB) and synovial fluid (SF) were stimulated to differentiate into or Treg cells. The activity STAT‐3 was knocked down by transfecting small interfering RNA (siRNA). After 3 days culture, proportions measured flow cytometry, production interleukin‐17 (IL‐17) reverse transcriptase–polymerase chain...
The objectives were to investigate the in vivo effects of treatment with rebamipide on pain severity and cartilage degeneration an experimental model rat osteoarthritis (OA) explore its mode action.OA was induced rats by intra-articular injection monosodium iodoacetate (MIA). Oral administration initiated day MIA injection, 3 or 7 days after. Limb nociception assessed measuring paw withdrawal latency threshold. We analyzed samples macroscopically histomorphologically, used...
Bone destruction and inflammation are closely linked. Cytokines play an important role in inflammatory bone by upregulating the receptor activator of nuclear factor-κB (NF-κB) ligand (RANKL). The direct cytokines that act a non-RANKL-dependent manner has yet to be elucidated. aim this study was investigate osteoclastogenic properties at different time-points osteoclastogenesis. Mouse marrow macrophages were stimulated with macrophage colony-stimulating factor (M-CSF) various concentrations...
Increases in oxidative stress are thought to be associated with the development of osteoarthritis (OA). Eupatilin, one major compounds present artemisia species, was shown have both anti-oxidative and anti-inflammatory properties. Here, we investigated vivo effects eupatilin on pain severity cartilage degradation an experimental rat model OA, along mechanisms action underlying these effects. Experimental OA induced via intra-articular injection monosodium iodoacetate (MIA), oral...
Rheumatoid arthritis (RA) is a chronic and systemic inflammatory disease characterized by upregulation of cell death osteoclastogenesis. Necrostatin (NST)-1s chemical inhibitor receptor-interacting serine/threonine-protein kinase (RIPK)1, which plays role in necroptosis. We investigated whether NST-1s decreases responses mouse model collagen-induced (CIA). decreased the progression CIA synovial expression proinflammatory cytokines. Moreover, treatment necroptosis mediators such as RIPK1,...
Abstract Scleroderma is an autoimmune disease that causes dermal fibrosis. It occurs when collagen accumulates in tissue as a result of persistent inflammation. Th17 cells and pro-inflammatory cytokines such IL-1β, IL-6, IL-17, TNF-α play important roles the pathogenesis scleroderma. Because metformin, medication used to treat diabetes, has effective immunoregulatory functions, we investigated its therapeutic function Mice model bleomycin-induced scleroderma were treated with metformin for 2...
Objective This study aimed to assess infection occurrence of and risk factors among ankylosing spondylitis (AS) patients treated with biologics in a real-world setting. Methods prospective observational cohort included AS from the Korean College Rheumatology BIOlogics (KOBIO) registry who initiated or switched biologic agent between December 2012 July 2023. The primary outcome was first any infection, ranging mild severe, classified by organ system. rate per 1,000 person-years (PY), 95%...
Background/Objectives: Rheumatoid arthritis-associated interstitial lung disease (RA-ILD) significantly affects prognosis and patient survival. The impact of conventional synthetic DMARDs (csDMARDs) biologic/targeted (b/tsDMARDs) on RA-ILD prognoses remains unclear. This study aimed to investigate the effects csDMARDs b/tsDMARDs progression based pulmonary function tests (PFTs), high-resolution computed tomography (HRCT), symptom changes. Methods: multicenter, retrospective, observational...
Rebamipide, a gastroprotective agent, has the ability to scavenge reactive oxygen radicals. Increased oxidative stress is implicated in pathogenesis of rheumatoid arthritis (RA). We undertook this study investigate impact rebamipide on development and pathophysiologic mechanisms by which attenuates severity murine model RA.Collagen-induced (CIA) was induced DBA/1J mice. Anti-type II collagen antibody titers interleukin-17 (IL-17) levels were determined using enzyme-linked immunosorbent...
Abstract Introduction Mesenchymal stem cells (MSCs) can protect bone marrow transplantation (BMT) recipients from the lethal acute graft-versus-host disease (aGVHD) development. However, mechanisms underlying anti-inflammatory properties of MSCs in aGVHD remain to be elucidated. The immunoregulatory are mediated by their production molecules, including IL-10 and TGF-β. On other hand, also produce proinflammatory cytokines during normal growth, such as IL-1β IL-6. These opposite actions may...
Objective Dual‐specificity phosphatase 5 (DUSP‐5) is a that specifically dephosphorylates both phosphoserine and phosphotyrosine residues of MAPK. The dysregulated activation MAPK contributes to the pathogenesis rheumatoid arthritis. This study was undertaken investigate therapeutic potential DUSP‐5 in preventing development autoimmune arthritis an animal model. Methods Autoimmune induced DBA/1J mice by immunization with type II collagen (CII). Eight days after CII immunization, were...
Objectives Treatment of patients with systemic sclerosis (SSc) can be challenging because clinical heterogeneity. Integration genome-scale transcriptomic profiling for SSc provide insights on patient categorisation and novel drug targets. Methods A normalised compendium was created from 344 skin samples 173 SSc, covering an intersection 17 424 genes eight data sets. Differentially expressed (DEGs) identified by three independent methods were subjected to functional network analysis, where...