A5100772656- COVID-19 epidemiological studies
- Peripheral Nerve Disorders
- Orthopedic Surgery and Rehabilitation
- Nerve Injury and Rehabilitation
- Botulinum Toxin and Related Neurological Disorders
- Lung Cancer Diagnosis and Treatment
- Radiation Dose and Imaging
- Medical Imaging Techniques and Applications
- COVID-19 Pandemic Impacts
- Shoulder Injury and Treatment
- Food Quality and Safety Studies
- Essential Oils and Antimicrobial Activity
- Advanced X-ray and CT Imaging
- SARS-CoV-2 detection and testing
- SARS-CoV-2 and COVID-19 Research
- Autophagy in Disease and Therapy
- Olfactory and Sensory Function Studies
- Lung Cancer Treatments and Mutations
- Tissue Engineering and Regenerative Medicine
- Anatomy and Medical Technology
- PI3K/AKT/mTOR signaling in cancer
- COVID-19 diagnosis using AI
- Innovative Microfluidic and Catalytic Techniques Innovation
- 3D Printing in Biomedical Research
- Dermatologic Treatments and Research
Korea University Medical Center
2016-2024
The University of Melbourne
2024
Monash University
2024
Inje University Busan Paik Hospital
2018-2024
Catholic University of Korea
2017-2024
Genome and Company (South Korea)
2022-2024
Western Health
2024
Korea University
2014-2023
National Institute of Food and Drug Safety Evaluation
2023
Konyang University
2020-2022
Abstract Fibroblast-like synoviocytes (FLSs) are a major cell population of the pannus that invades cartilage and bone in rheumatoid arthritis (RA). FLS resistance to apoptosis is characteristic RA. The aims this study were investigate effects interleukin-17 (IL-17) IL-17-producing T helper (Th17) cells on FLSs from RA patients (RA FLSs) their roles mitochondrial dysfunction autophagy. Mitochondrial function was assessed osteoarthritis (OA FLSs). treated with IL-17 morphological features,...
Background:The impact of coronavirus disease 2019 (COVID-19) has profoundly affected education, with most universities changing face-to-face classes to online formats.To adapt the COVID-19 pandemic situation, we adopted a blended learning approach anatomy instruction that included lectures, pre-recorded laboratory dissection videos, and 3D applications, condensed offline cadaver dissection.Methods: We aimed examine outcomes newly educational by 1) comparing academic achievement between group...
The tumor microenvironment (TME) is the environment around tumor, including blood vessels, immune cells, fibroblasts, signaling molecules, and extracellular matrix (ECM). Owing to its component interactions, TME influences growth drug delivery in a highly complex manner. Although several vascularized cancer models are developed mimic vitro, these cannot comprehensively reflect vessel-tumor spheroid interactions. Here, method for inducing controlled angiogenesis by engineering presented....
Scaffolds for the production of cultivated meat, a promising sustainable meat alternative, should exhibit physical and chemical properties that enable three-dimensional animal cell culture, along with biological characteristics support attachment, proliferation, differentiation. Additionally, scaffold be crafted from edible materials offer textural similarities to have minimal influence on flavor taste. Herein, an alginate-based alginate-cellulose hydrogel (ACe-gel) derived brown alga...
Abstract Background After relaxing social distancing measures, South Korea experienced a resurgent second epidemic wave of coronavirus disease 2019 (COVID-19). In this study, we aimed to identify the transmission dynamics severe acute respiratory syndrome 2 (SARS-CoV-2) infections and assess impact COVID-19 case finding contact tracing in each wave. Methods We collected data on cases published by local public health authorities divided study into two periods (19 January–19 April 2020 for...
Abstract The pathogenesis of keloids has not been elucidated, and the disease is thought to be caused by abnormal secretion proinflammatory mediators irregular responses other inflammatory signals mediated keloid fibroblasts (KFs). In this study, we investigated whether a local increase in interleukin IL-17 tissues stimulates production stromal cell–derived factor-1 (SDF-1) KFs causing further recruitment IL-17-producing T helper 17 (Th17) cells, which subsequently creates positive feedback...
Abstract Nuclear factor-erythroid 2-related factor 2 (Nrf2) is a key transcriptional regulator of several antioxidant and anti-inflammatory enzymes. It binds to its endogenous inhibitor Kelch-like ECH-associated protein 1 (Keap1) in the cytoplasm under normal conditions. Various or environmental oxidative stresses can disrupt Nrf2/Keap1 complex, allowing Nrf2 translocate into nucleus, where it induces transcription various cytoprotective enzymes by binding responsive elements. These have...
We estimated mean serial interval and superspreading potential for the Delta variant of severe acute respiratory syndrome coronavirus 2 in South Korea. Intervals were similar first (3.7 days) second (3.5 study periods. Risk events was also similar; 23% 25% cases, respectively, seeded 80% transmissions.
Abstract Objectives This study aimed to assess the impact of super-resolution deep learning reconstruction (SR-DLR) on coronary CT angiography (CCTA) image quality and blooming artifacts from artery stents in comparison conventional methods, including hybrid iterative (HIR) learning-based (DLR). Methods A retrospective analysis included 66 CCTA patients July November 2022. Major arteries were evaluated for noise, signal-to-noise ratio (SNR), contrast-to-noise (CNR). Stent sharpness was...
Follicular helper T (T FH ) cells mediate germinal center reactions to generate high affinity antibodies against specific pathogens, and their excessive production is associated with the pathogenesis of systemic autoimmune diseases such as lupus erythematosus (SLE). ETV5, a member ETS transcription factor family, promotes cell differentiation in mice. In this study, we examined role ETV5 mice humans. cell–specific deletion Etv5 alleles ameliorated phenotypes mouse models. Further, identified...
<title>Abstract</title> The plantaris muscle (PM), considered vestigial in humans, has clinical significance owing to its anatomical variations. This study examined the prevalence, origin types, and relevance of PM Korean population aid surgical practices, particularly posterior knee surgery. A total 160 lower limbs (90 male, 70 female) were dissected using classical methods. morphology was classified, prevalence evaluated. present 146 (91.25%). Three distinct types observed: Type 1 (75%),...
Abstract Caffeic acid phenethyl ester (CAPE) is an active ingredient of beehive propolis with a structure similar to phenolic acid. The estrogenic effects were previously demonstrated through the activation estrogen receptor. To identify properties propolis, CAPE was evaluated using in vitro and vivo methods. showed selective binding affinity human receptor β (hERβ) rather than hERα. also reduced ERα expression MCF‐7 MDA 231 cells. In yeast transcription assay, produced transcriptional...
Purpose To prospectively evaluate whether Lung-RADS classification and volumetric nodule assessment were feasible with ultralow-dose (ULD) chest CT scans deep learning image reconstruction (DLIR). Methods The institutional review board approved this prospective study. This study included 40 patients (mean age, 66±12 years; 21 women). Participants sequentially underwent LDCT ULDCT (CTDIvol, 0.96±0.15 mGy 0.12±0.01 mGy) reconstructed the adaptive statistical iterative reconstruction-V 50%...
This study identified the volatile organic compounds in essential oils that are extracted from Chrysanthemum indicum Linné (C. Linné) and investigated effects of inhalation these compounds. We detected a total 41 compounds, including 32 hydrocarbons, four acids, three alcohols, two ketones, one aldehyde. In sniffing test, seven types were identified. Furthermore, C. found to be derived 1,8-cineole camphor. After oils, subjects' systolic blood pressure heart rate decreased. indicates provides...
In this study, we investigated the effects of potential probiotic Bacillus subtilis CSY191 on fatty acid profiles Cheonggukjang, a fermented soybean paste, prepared using new Korean brown cultivars, protein-rich cultivar (Saedanbaek), and oil-rich (Neulchan). Twelve acids were identified in sample set-myristic, palmitic, palmitoleic, stearic, oleic, vaccenic, linoleic, α-linolenic, arachidic, gondoic, behenic, lignoceric acids-yet, no specific changes driven by fermentation noted profiles....
Abstract South Korea is experiencing the community transmission of SARS-CoV-2 Omicron variant (B.1.1.529). We estimated that mean (± standard deviation) serial interval was 2.22 1.62) days, and basic reproduction number 1.90 (95% Credible Interval, 1.50–2.43) for outbreak in Korea.
Salmon fish farmers face remarkable problems in rearing and handling due to the spread of disease by infectious pancreatic necrosis virus (IPNV). Therefore, we developed a straightforward sensitive technique detect IPNV-based on recombinant human apoferritin heavy chain (hAFN-H) protein nanoparticles. In this study, 24 subunits hAFN-H were genetically modified express 6×His-tag protein-G at their C-terminal site using Escherichia coli. We thus achieved two-step signal amplifying strategy...
This cohort study investigates the association between relaxation of public health and social measures daily cases SARS-CoV-2 Omicron variant infection in South Korea.
This study aimed to investigate the changes in human EEG activity, Brodmann area, and blood pressure during basil essential oil inhalation. Seven odor-active compounds were detected by GC–MS combined with GC–olfactometry, three abundant volatile electronic nose. Linalool was simultaneously regarded as a major compound. The systolic diastolic pressures pulse levels showed decreasing trend BEO relative beta gamma waves most brain regions changed decreased, whereas increased In particular, left...