A5089896199- Transcranial Magnetic Stimulation Studies
- Cerebral Palsy and Movement Disorders
- EEG and Brain-Computer Interfaces
- Neonatal and fetal brain pathology
- Muscle activation and electromyography studies
- Stroke Rehabilitation and Recovery
- Neuroscience and Neural Engineering
- Spinal Cord Injury Research
- Obsessive-Compulsive Spectrum Disorders
- Motor Control and Adaptation
- Gaze Tracking and Assistive Technology
- Botulinum Toxin and Related Neurological Disorders
- Attention Deficit Hyperactivity Disorder
- Intraoperative Neuromonitoring and Anesthetic Effects
- Hemispheric Asymmetry in Neuroscience
- Cognitive Functions and Memory
- Vestibular and auditory disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Children's Physical and Motor Development
- Assistive Technology in Communication and Mobility
- Neurology and Historical Studies
- Traumatic Brain Injury Research
- Congenital Heart Disease Studies
- Epilepsy research and treatment
- Eating Disorders and Behaviors
University of Calgary
2015-2025
Alberta Children's Hospital
2016-2025
Alberta Children's Hospital Research Institute
2016-2025
Ontario Brain Institute
2019-2022
Calgary Laboratory Services
2019-2020
University of Alberta
2011-2017
Alberta Health Services
2016
Glenrose Rehabilitation Hospital
2016
Allen Institute for Brain Science
2016
Importance Current upper-extremity therapies provide inconsistent outcomes for children with unilateral cerebral palsy. Noninvasive brain stimulation, specifically transcranial direct current may enhance motor gains when combined therapy. Objective To determine whether the addition of neurostimulation to therapy enhances function in perinatal stroke and Design, Setting, Participants This multicenter, randomized, sham-controlled phase 3 trial was conducted from July 2017 through March 2023....
Non-invasive brain stimulation is being increasingly used to interrogate neurophysiology and modulate function. Despite the high scientific therapeutic potential of non-invasive stimulation, experience in developing has been limited.To determine safety tolerability neurostimulation children across diverse modalities pediatric populations.A program was established 2008 at our pediatric, academic institution. Multi-disciplinary neurophysiological studies included single- paired-pulse...
<h3>Objective:</h3> To determine whether the addition of transcranial direct current stimulation (tDCS) to intensive therapy increases motor function in children with perinatal stroke and hemiparetic cerebral palsy. <h3>Methods:</h3> This was a randomized, controlled, double-blind clinical trial. Participants were recruited from population-based cohort MRI-classified unilateral stroke, age 6 18 years, disabling hemiparesis. All completed goal-directed, peer-supported, 2-week after-school...
Background: The options for severely disabled children with intact cognition to interact their environment are extremely limited. A brain computer interface (BCI) has the potential allow such persons gain meaningful function, communication, and independence. While pediatric population might benefit most from BCI technology, research date been predominantly in adults. Methods: In this prospective, cross-over study, we quantified ability of healthy school-aged perform simple tasks using a...
To explore the feasibility and possible effects of low-frequency repetitive transcranial magnetic stimulation (rTMS) delivered to supplementary motor area (SMA) on tic severity system neurophysiology in children with Tourette syndrome.Ten syndrome (eight males, two females; 9-15y) participated this open-label, phase 1 clinical trial. Treatment consisted 1800 (1Hz) neuronavigated robotic rTMS (100% resting threshold) SMA, bilaterally for 15 sessions. The primary outcome was a change Yale...
Background. Perinatal stroke causes most hemiparetic cerebral palsy. Ipsilateral connections from nonlesioned hemisphere to affected hand are common. The primary motor cortex (M1) determines function and is a potential therapeutic target but its neurophysiology poorly understood. Objective. We aimed characterize the neurophysiological properties of M1 in children with perinatal their relationship clinical function. Methods. Fifty-two participants palsy magnetic resonance imaging–confirmed 40...
Background: Transcranial direct current stimulation (tDCS) can improve motor learning in children. High-definition approaches (HD-tDCS) have not been examined Objectives/Hypothesis: We hypothesized that primary cortex HD-tDCS would enhance but be inferior to tDCS Methods: Twenty-four children were recruited for a randomized, sham-controlled, double-blinded interventional trial (NCT03193580, clinicaltrials.gov/ct2/show/NCT03193580) receive 1) right hemisphere (contralateral) (M1) 1mA anodal...
Background: Major depressive disorder (MDD) is common in youth and treatment options are limited. We evaluated the effectiveness safety of repetitive transcranial magnetic stimulation (rTMS) adolescents transitional aged with resistant MDD. Methods: Thirty-two outpatients moderate to severe, treatment-resistant MDD, 13 – 21 years underwent a three-week, open-label, single center trial rTMS (ClinicalTrials.gov identifier NCT01731678). was applied left dorsolateral prefrontal cortex (DLPFC)...
Thousands of youth suffering from acquired brain injury or other early-life neurological disease live, mature, and learn with only limited communication interaction their world. Such cognitively capable children are ideal candidates for brain-computer interfaces (BCI). While BCI systems rapidly evolving, a fundamental gap exists between technological innovators the patients families who stand to benefit. Forays into translating in recent years have revealed that kids can operate simple...
Aim To characterize fatigue in children with hemiparesis perinatal stroke and explore associations measures of motor performance corticospinal excitability. Method Forty‐five (16 females, 29 males), aged 6 to 18 years (mean [SD] 12y [4]), magnetic resonance imaging‐confirmed participated. Associations between (Pediatric Quality Life Inventory Version 3.0 cerebral palsy module subscale), (Assisting Hand Assessment [AHA], Box Blocks Test, grip strength), excitability projections both hands...
We aimed to determine if the mirror movements that often result in children with unilateral cerebral palsy (CP) after perinatal stroke represent a clinical biomarker of developmental plasticity.This was prospective, controlled cohort study. Mirror CP from population-based were compared those typically developing controls. The population assessed further via electromyography (EMG), motor function, and corticospinal organization investigations. quantified (0-5) bidirectionally. EMG during...
Perinatal stroke is the leading cause of hemiparetic cerebral palsy resulting in lifelong disability for millions people worldwide. Options motor rehabilitation are limited, especially most severely affected children. Brain computer interfaces (BCIs) sample brain activity to allow users control external devices. Functional electrical stimulation enhances recovery after stroke, and BCI-activated functional was recently shown improve upper extremity function adult stroke. We aimed determine...
Transcallosal fibers facilitate interhemispheric networks involved in motor tasks. Despite their clinical relevance, control systems have not been completely defined the developing brain. The objective of this study was to examine developmental profile transcallosal inhibition healthy children and adolescents. Nineteen typically right-handed participants were recruited. Two transcranial magnetic stimulation (TMS) paradigms assessed inhibition: ipsilateral silent periods (iSP) paired-pulse...
Background: Children with severe motor impairment but intact cognition are deprived of fundamental human rights. Quadriplegic cerebral palsy is the most common scenario where rehabilitation options remain limited. Brain-computer interfaces (BCI) represent a potential solution, pediatric populations have been neglected. Direct engagement children and families could provide meaningful opportunities while informing program development. We describe patient-centered, clinical, non-invasive BCI program.
Background. Clinical trials are suggesting efficacy of intensive therapy combined with brain stimulation to improve hand function in hemiparetic children perinatal stroke. However, individual variability exists and the underlying neuroplasticity mechanisms unknown. Exploring primary motor cortex (M1) neurophysiology, how it changes such interventions, may provide valuable biomarkers for advancing personalized neurorehabilitation. Methods. Forty-five (age 6-19 years) hemiparesis participated...
Abstract Background Individuals with severe neurological disabilities but preserved cognition, including children, are often precluded from connecting their environments. Brain computer interfaces (BCI) a potential solution where advancing technologies create new clinical opportunities. We evaluated clinician awareness as modifiable barrier to progress and identified eligible populations. Methods executed national, population-based, cross-sectional survey of physician specialists caring for...
Perinatal stroke (PS) causes most hemiparetic cerebral palsy (CP) and results in lifelong disability. Children with severe hemiparesis have limited rehabilitation options. Brain computer interface- activated functional electrical stimulation (BCI-FES) of target muscles may enhance upper extremity function adults. We conducted a pilot clinical trial to assess the safety feasibility BCI-FES children CP.Thirteen participants (mean age = 12.2 years, 31% female) were recruited from...