A5081732306- COVID-19 epidemiological studies
- Influenza Virus Research Studies
- SARS-CoV-2 and COVID-19 Research
- Respiratory viral infections research
- COVID-19 Pandemic Impacts
- Data-Driven Disease Surveillance
- Animal Disease Management and Epidemiology
- Viral Infections and Vectors
- Vaccine Coverage and Hesitancy
- SARS-CoV-2 detection and testing
- COVID-19 and Mental Health
- Viral Infections and Outbreaks Research
- COVID-19 Clinical Research Studies
- COVID-19 Digital Contact Tracing
- Diabetes and associated disorders
- Infection Control and Ventilation
- Energy Load and Power Forecasting
- Atrial Fibrillation Management and Outcomes
- Animal Virus Infections Studies
- Ultrasound in Clinical Applications
- Misinformation and Its Impacts
- Cardiac Imaging and Diagnostics
- Fatty Acid Research and Health
- vaccines and immunoinformatics approaches
- Immunotherapy and Immune Responses
Hong Kong Science and Technology Parks Corporation
2021-2025
University of Hong Kong
2016-2025
Laboratory of Data Discovery for Health
2021-2025
Burnaby Hospital
2021-2023
Institute of Infection and Immunity
2023
Korea Disease Control and Prevention Agency
2022
Peter Doherty Institute
2021
The University of Melbourne
2021
University of Florida
2018-2019
Sustainable Sciences Institute
2018
A range of public health measures have been implemented to suppress local transmission coronavirus disease 2019 (COVID-19) in Hong Kong. We examined the effect these interventions and behavioural changes on incidence COVID-19, as well influenza virus infections, which might share some aspects dynamics with COVID-19.We analysed data laboratory-confirmed COVID-19 cases, surveillance outpatients all ages, hospitalisations children. estimated daily effective reproduction number (Rt) for H1N1...
Superspreading events (SSEs) have characterized previous epidemics of severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East (MERS-CoV) infections1–6. For SARS-CoV-2, the degree to which SSEs are involved in transmission remains unclear, but there is growing evidence that might be a typical feature COVID-197,8. Using contact tracing data from 1,038 SARS-CoV-2 cases confirmed between 23 January 28 April 2020 Hong Kong, we identified all local clusters infection. We 4–7...
When a new infectious disease emerges, appropriate case definitions are important for clinical diagnosis and public health surveillance. Tracking numbers over time is to establish the speed of spread effectiveness interventions. We aimed assess whether changes in affected inferences on transmission dynamics coronavirus 2019 (COVID-19) China.We examined definition COVID-19 mainland China during first epidemic wave. used exponential growth models estimate how number cases reported each day....
Background. Influenza A(H7N9) viruses isolated from humans show features suggesting partial adaptation to mammals. To provide insights into the pathogenesis of H7N9 virus infection, we compared risk factors, clinical presentation, and progression patients hospitalized with H7N9, H5N1, 2009 pandemic H1N1 (pH1N1) infections.
Background. Viral shedding is often considered to correlate with the infectivity of influenza, but evidence for this limited.
Previous studies have established that antibody titer measured by the hemagglutination-inhibiting (HAI) assay is correlated with protection against influenza virus infection, an HAI of 1:40 generally associated 50% protection.We recruited index cases confirmed infection from outpatient clinics, and followed up their household contacts for 7-10 days to identify secondary infections. Serum samples collected a subset were tested microneutralization (MN) assays prevalent viruses. We analyzed...
Using detailed exposure information on COVID-19 cases, we estimated the mean latent period to be 5.5 (95% CI: 5.1-5.9) days, shorter than incubation (6.9 days). Laboratory testing may allow quarantines since 95% of cases shed virus within 10.6 9.6-11.6) days infection.
Abstract Superspreading events have characterised previous epidemics of severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East (MERS-CoV) infections. Using contact tracing data, we identified characterized SARS-CoV-2 clusters in Hong Kong. Given a superspreading threshold 6-8 secondary cases, 5-7 probable evidence substantial overdispersion transmissibility, estimated that 20% cases were responsible for 80% local transmission. Among terminal cluster 27% (45/167) ended...
ABSTRACT Background A range of public health measures have been implemented to delay and reduce local transmission COVID-19 in Hong Kong, there major changes behaviours the general public. We examined effect these interventions behavioral on incidence as well influenza virus infections which may share some aspects dynamics with COVID-19. Methods reviewed policy measured population through two telephone surveys, January 20-23 February 11-14. analysed data laboratory-confirmed cases,...
Previous studies suggest that the nose/throat microbiome may play an important role in shaping host immunity and modifying risk of respiratory infection. Our aim is to quantify association between susceptibility influenza virus
Hong Kong contained COVID-19 for two years but experienced a large epidemic of Omicron BA.2 in early 2022 and endemic transmission subvariants thereafter. We reflected on pandemic preparedness responses by assessing associated disease burden the context implementation various public health social measures (PHSMs).We examined use impact controls analysing data more than 1.7 million confirmed cases characterizing temporal changes non-pharmaceutical pharmaceutical interventions implemented from...
Hong Kong experienced a surge of Omicron BA.2 infections in early 2022, resulting one the highest per-capita death rates COVID-19. The outbreak occurred dense population with low immunity towards natural SARS-CoV-2 infection, high vaccine hesitancy vulnerable populations, comprehensive disease surveillance and capacity for stringent public health social measures (PHSMs). By analyzing genome sequences epidemiological data, we reconstructed epidemic trajectory wave found that initial community...
Background. The pandemic potential of avian influenza viruses A(H5N1) and A(H7N9) remains an unresolved but critically important question.
Since 2014, 17 human cases of infection with the newly emerged highly pathogenic avian influenza A(H5N6) virus have been identified in China to date. The epidemiologic characteristics laboratory-confirmed were compared A(H5N1) and A(H7N9) mainland China.Data on H5N6, H5N1, H7N9 analyzed compare clinical severity. Severity confirmed H5N1 was estimated based risk severe outcomes hospitalized cases.H5N6 older than a higher prevalence underlying medical conditions but younger cases....
Abstract Background The relative contributions of asymptomatic, presymptomatic, and symptomatic transmission severe acute respiratory syndrome coronavirus 2 have not been clearly measured, although control measures may differ in response to the risk spread posed by different types cases. Methods We collected detailed information on events symptom status based laboratory-confirmed patient data contact tracing from 4 provinces 1 municipality China. estimated variation over time severity...
Hong Kong has implemented stringent public health and social measures (PHSMs) to curb each of the four COVID-19 epidemic waves since January 2020. The third wave between July September 2020 was brought under control within 2 m, while fourth starting from end October taken longer bring lasted at least 5 mo. Here, we report pandemic fatigue as one potential reasons for reduced impact PHSMs on transmission in wave. We contacted either 500 or 1,000 local residents through weekly random-digit...
Abstract Many locations around the world have used real-time estimates of time-varying effective reproductive number ( $${R}_{t}$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msub> <mml:mrow> <mml:mi>R</mml:mi> </mml:mrow> <mml:mi>t</mml:mi> </mml:msub> </mml:math> ) COVID-19 to provide evidence transmission intensity inform control strategies. Estimates are typically based on statistical models applied case counts and suffer lags more than a week because latent period...
Soon after a mask mandate was relaxed (March 1, 2023), the first post-COVID-19 influenza season in Hong Kong lasted 12 weeks. After other preventive measures were accounted for, wearing associated with an estimated 25% reduction transmission. Influenza resurgence probably resulted from relaxation of mandates and measures.
Importance Hong Kong was held as an exemplar for pandemic response until it recorded the world’s highest daily COVID-19 mortality, which likely due to vaccine refusal. To prevent this high mortality in future pandemics, information on underlying reasons refusal is necessary. Objectives track evolution of vaccination willingness and uptake from before rollout mass vaccination, examine factors associated with compare data Singapore, assess population attributable fraction Design, Setting,...