A5018321738- Hepatitis B Virus Studies
- Influenza Virus Research Studies
- Hepatitis C virus research
- Respiratory viral infections research
- Liver Disease Diagnosis and Treatment
- Hepatitis Viruses Studies and Epidemiology
- COVID-19 epidemiological studies
- Viral gastroenteritis research and epidemiology
- Liver Disease and Transplantation
- Viral Infections and Outbreaks Research
- Infection Control and Ventilation
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Viral Infections and Vectors
- Tuberculosis Research and Epidemiology
- Pneumonia and Respiratory Infections
- Animal Disease Management and Epidemiology
- COVID-19 and healthcare impacts
- Vaccine Coverage and Hesitancy
- Mycobacterium research and diagnosis
- COVID-19 and Mental Health
- Child Nutrition and Water Access
- Virology and Viral Diseases
- Immunotherapy and Immune Responses
- Zoonotic diseases and public health
Second Affiliated Hospital of Zhejiang University
2023-2025
Zhejiang University
2016-2025
State Key Laboratory of Diagnosis and Treatment of Infectious Diseases
2015-2024
First Affiliated Hospital Zhejiang University
2012-2023
National Clinical Research
2023
National Clinical Research Center for Digestive Diseases
2022-2023
Chinese PLA General Hospital
2023
Yale University
2020-2021
Jingning County People's Hospital
2021
Shanghai Sixth People's Hospital
2020
Risk for transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to close contacts infected persons has not been well estimated.
Abstract Background Rapid spread of SARS-CoV-2 in Wuhan prompted heightened surveillance Guangzhou and elsewhere China. Modes contact risk transmission among close contacts have not been well estimated. Methods We included 4950 closes from Guangzhou, extracted data including modes contact, laboratory testing, clinical characteristics confirmed cases source cases. used logistic regression analysis to explore the factors associated with infection contacts. Results Among contacts, median age...
Rotavirus is the leading global pathogen of diarrhea-associated mortality and poses a great threat to public health in all age groups. This study aimed explore burden 30-year change patterns rotavirus infection-associated deaths.Based on Global Burden Disease 2019 Study (GBD 2019), we analyzed age-standardized death rate (ASDR) infection by sex, geographical region, sociodemographic index (SDI) from 1990 2019. A Joinpoint regression model was used analyze trends over 30 years, SaTScan...
Abstract Host-adaptive strategies, such as the E627K substitution in PB2 protein, are critical for replication of avian influenza A viruses mammalian hosts. Here we show that mutation PB2-K526R is present some human H7N9 isolates, nearly 80% H5N1 isolates from Indonesia and, conjunction with E627K, almost all seasonal H3N2 since 1970. Polymerase complexes containing PB2-526R derived H7N9, or exhibit increased polymerase activity. also enhances viral transcription and cells. In comparison...
The effect of corticosteroids on influenza A(H1N1)pdm09 viral pneumonia patients remains controversial, and the impact dosage has never been studied. Using data hospitalized adolescent adult with pneumonia, prospectively collected from 407 hospitals in mainland China, effects low-to-moderate-dose (25-150 mg d-1 ) high-dose (>150 30-day mortality, 60-day nosocomial infection were assessed multivariate Cox regression propensity score-matched case-control analysis. In total, 2141 (median age:...
Background. Influenza A(H7N9) viruses isolated from humans show features suggesting partial adaptation to mammals. To provide insights into the pathogenesis of H7N9 virus infection, we compared risk factors, clinical presentation, and progression patients hospitalized with H7N9, H5N1, 2009 pandemic H1N1 (pH1N1) infections.
ObjectivesTo track the prevalence trends of latent tuberculosis infection (LTBI) at global, regional, and national levels.MethodsData on LTBI were extracted from Global Burden Disease database. The average annual percent change (AAPC) was estimated by joinpoint regression used to evaluate epidemic disease.ResultsGlobally, rate decreased 30.66% in 1990 23.67% 2019, with an AAPC -0.9%. varied 5.02% (Jordan) 48.35% (Uganda) 2.51% 43.75% (Vietnam) 2019 country level. all six World Health...
ObjectiveUnderstanding the global patterns of respiratory syncytial virus (RSV) is crucial for developing effective prevention and control strategies.MethodsData on RSV-related burden were extracted from Global Burden Disease 2019. Joinpoint regression models used to assess temporal trends RSV further stratified analyses conducted according Socio-demographic Index (SDI), which a composite measure income, education, total fertility. Age-period-cohort model was evaluate age, period, cohort...
Abstract The coexistence of coronavirus disease 2019 (COVID-19) and seasonal influenza epidemics has become a potential threat to human health, particularly in China the oncoming season. However, with relaxation nonpharmaceutical interventions (NPIs) during COVID-19 pandemic, rebound extent activities is still poorly understood. In this study, we constructed susceptible–vaccinated–infectious–recovered–susceptible (SVIRS) model simulate transmission calibrated it using surveillance data from...
This study aimed to investigate region-specific epidemiologic characteristics of influenza and transmission zones (ITZs).Weekly surveillance data 156 countries from 1996 2021 were obtained using FluNet. Joinpoint regression was used describe global virus trends, clustering analyses classify the ITZs.The median average positive rate for total 16.19% (interquartile range: 11.62-25.70%). Overall, three major subtypes (influenza H1, H3, B viruses) showed alternating epidemics. Notably,...