A5109185520- Influenza Virus Research Studies
- Animal Disease Management and Epidemiology
- Respiratory viral infections research
- interferon and immune responses
- Viral Infections and Vectors
- Pneumonia and Respiratory Infections
- Viral gastroenteritis research and epidemiology
- vaccines and immunoinformatics approaches
- Inhalation and Respiratory Drug Delivery
- Animal Virus Infections Studies
- Coronary Interventions and Diagnostics
- Platelet Disorders and Treatments
- Plant Virus Research Studies
- SARS-CoV-2 detection and testing
- Virology and Viral Diseases
- Immune Response and Inflammation
- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- T-cell and Retrovirus Studies
- Blood properties and coagulation
- Drug-Induced Hepatotoxicity and Protection
- Cervical Cancer and HPV Research
- Transgenic Plants and Applications
- Peptidase Inhibition and Analysis
- Atrial Fibrillation Management and Outcomes
Yangzhou University
2019-2025
Ministry of Agriculture and Rural Affairs
2022-2024
Guangdong Ocean University
2023
Sun Yat-sen Memorial Hospital
2023
Sun Yat-sen University
2023
Second Affiliated Hospital of Chengdu University of Traditional Chinese
2023
The Affiliated Yongchuan Hospital of Chongqing Medical University
2023
Xiangya Hospital Central South University
2023
Tongren Hospital
2023
Ruikang Affiliated Hospital of Guangxi Medical University
2023
Serological surveillance conducted in areas of an outbreak influenza A(H7N9) infection China found no seropositivity for antibodies specific avian-origin among 1129 individuals the general population, whereas >6% 396 poultry workers were positive (on basis a hemagglutination inhibition titer ≥ 80) this subtype, confirming that infected is principal source human infections and subclinical are possible. Fourteen days after symptom onset, elevated levels to 65.8% patients (25/38) who survived...
ObjectiveThe risk factors and the impact of NAI treatments in patients with severe influenza A-associated pneumonia remain unclear.MethodsA multicenter, retrospective, observational study was conducted Zhejiang, China during a epidemic August 2017–May 2018. Clinical records (>14 y) hospitalized laboratory-confirmed A virus infection who developed were compared to those mild-to-moderate pneumonia. Risk related severity effects (monotherapy combination peramivir oseltamivir)...
Background There is limited data on the clinical outcome of patients with pandemic H1N1 (pH1N1) pneumonia who received oseltamivir treatment, especially when treatment was administered more than 48 hours after symptom onset. Methods During in 2009, a cohort pH1N1 influenza built China, and their information collected systematically, analyzed Cox models. Results 920 adults 541 children didn't receive corticosteroids were analyzed. In-hospital mortality higher did not antiviral therapy (18.2%)...
The novel H10N3 avian influenza virus (AIV) has infected four individuals since 2021 and caused severe respiratory damage, posing a significant threat to public health. However, its pathogenic mechanisms remain poorly understood. Our findings revealed that infection induces lung damage causes death in mice, even at low doses. elevated levels of multiple pro-inflammatory factors the bronchoalveolar lavage fluid were significantly increased during infection, displaying hallmarks cytokine...
H9N2 avian influenza viruses (AIVs) pose an increasing threat to the poultry industry worldwide and have pandemic potential. Vaccination has been principal prevention strategy control in China since 1998, but vaccine effectiveness is persistently challenged by emergence of genetic and/or antigenic variants. Here, we analysed characteristics China, including 70 HA sequences isolates from poultry, 7358 online databases during 2010–2020, 15 early reference strains. Bayesian analyses based on...
Abstract Background Novel Influenza A (H1N1) is an acute respiratory infectious disease. Animal experiments indicated that when H1N1 virus infected early hosts, it showed strong CD4 + , CD8 and CD25 T cell reactions. The aim of this study was to investigate the dynamic fluctuations peripheral blood lymphocyte subgroups in patients with swine-origin influenza (S-OIV). Methods frequency cells, B natural killer (NK) regulatory cells (Treg) 36 severe 40 moderate were detected at different...
A severe seasonal influenza epidemic was observed during 2017–2018 in China, prompting questions on clinical characteristics and outcomes of cases with influenza. We retrospectively collected data laboratory-confirmed hospitalized patients (severe to critical) Jan-2011 Feb-2018 from five hospitals, followed by a systematic analysis 2017 2018 (n = 289) all previous epidemics 2011–2017 169). In-hospital fatality over 5-folds higher the (p < 0.01) which 19 died (6.6%), whereas only 2...
To determine sensitivity of rapid diagnostic tests for detecting influenza A(H7N9) virus, we compared with PCR results and tested different types clinical samples. Usefulness seasonal virus infections is limited because their low in upper respiratory tract specimens.
Genotype S H9N2 avian influenza virus, which has been predominant in China since 2010, contributed its entire internal gene cassette to the genesis of novel reassortant viruses, including H5Nx, H7N9 and H10N8 viruses that pose great threat poultry humans. A key feature genotype virus is substitution G1-like M PB2 genes for earlier F/98-like H virus. However, how this influenced viral adaptability emerging mammals remains unclear. We report here H5Nx with displayed enhanced replication...
Abstract Background Hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) is a serious disease with pathogenesis remaining unclear. This study aims to investigate the association between testosterone levels, stage (early, middle, or late, categorized according clinical manifestation), severity scores, and outcomes of HBV-ACLF. Methods single-center observational involved 160 male patients HBV-ACLF, 151 chronic hepatitis without (CHB) 106 healthy controls (HC). Morning blood...
Objectives To determine the upper limits of 95 th percentile reference intervals (RIs) for detection pro-gastrin releasing peptide (ProGRP) in plasma according to Clinical and Laboratory Standards Institute (CLSI) C28-A3 guideline a population adult Chinese Han ethnicity. Methods Plasma samples were collected from 578 healthy adults. ProGRP values measured by chemiluminescent microparticle immunoassay (CMIA) on Abbot ARCHITECT i2000 system analyzers. Results did not conform Gaussian...
Influenza A virus (IAV) continues to pose a pandemic threat public health, resulting high mortality rate annually and during years. Posttranslational modification of viral protein plays substantial role in regulating IAV infection. Here, based on immunoprecipitation (IP)-based mass spectrometry (MS) purified virus-coupled MS, total 89 phosphorylation sites distributed among 10 encoded proteins were identified, including 60 novel sites. Additionally, for the first time, we provide evidence...
Newcastle disease virus (NDV), known as avian paramyxovirus-1, poses a significant threat to poultry production worldwide. Vaccination currently stands the most effective strategy for control. However, mesogenic vaccine strain Mukteswar has been observed evolve into velogenic variant JS/7/05/Ch during immunization. Here, we aimed explore mechanisms underlying virulence enhancement of two viruses. Pathogenically, mediated stronger and pathogenicity in vivo compared Mukteswar. Comparative...
Straightforward point-of-care devices are essential for easier diagnostics of infectious diseases like influenza. Recent integrated microfluidic systems that use Reverse Transcriptase Polymerase Chain Reaction (RT-PCR) amplifying viral nucleic acids have sensing (detection) module is not directly coupled to the amplification module. This attributed fact modules require single stranded (ss) acid hybridization, but resultant amplicon conventional double (ds). needs be processed before being...
Influenza virus, the causative agent of influenza, has characteristics fast transmission and strong infectivity, posing a major threat to public health. Currently, with widely use first-line antiviral neuraminidase inhibitors, drug-resistant strains have appeared brought difficulties precaution treatment influenza. This article reviews influenza virus structural characteristics, drug-resistance mechanisms, resistance situation detection methods strains, aiming provide reference for future...