A5084364957- Malaria Research and Control
- Urinary Bladder and Prostate Research
- Mosquito-borne diseases and control
- Immune Response and Inflammation
- Hepatitis B Virus Studies
- Bacteriophages and microbial interactions
- Toxoplasma gondii Research Studies
- Cancer Research and Treatments
- Insect Resistance and Genetics
- Urological Disorders and Treatments
- Nanoplatforms for cancer theranostics
- Parasites and Host Interactions
- Liver Disease Diagnosis and Treatment
- Molecular Biology Techniques and Applications
- Vector-borne infectious diseases
- Cancer-related molecular mechanisms research
- Mycobacterium research and diagnosis
- Tuberculosis Research and Epidemiology
- Epigenetics and DNA Methylation
- Monoclonal and Polyclonal Antibodies Research
- Intensive Care Unit Cognitive Disorders
- Bladder and Urothelial Cancer Treatments
- Tissue Engineering and Regenerative Medicine
- Hematological disorders and diagnostics
- HIV Research and Treatment
Shenzhen Institutes of Advanced Technology
2025
Chinese Academy of Sciences
2025
Bengbu Medical College
2014-2024
Nanjing Medical University
2024
Nantong University
2024
Chongqing Medical University
2019-2024
Shantou University
2024
Zhejiang Gongshang University
2024
Taizhou People's Hospital
2024
Zhejiang University
2007-2021
To evaluate viral loads at different stages of disease progression in patients infected with the 2019 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) during first four months epidemic Zhejiang province, China.
The development of flower scents was a crucial event in biological evolution, providing olfactory signals by which plants can attract pollinators. In this study, bioinformatics, metabolomics, and biochemical molecular methodologies were integrated to investigate the candidate genes involved biosynthesis volatile components two cultivars Freesia x hybrida, Red River® Ambiance, release different categories compounds. We found that terpene synthase (TPS) pivotal determining spatiotemporal...
Abstract Background Loop-mediated isothermal amplification (LAMP) is a high performance method for detecting DNA and holds promise use in the molecular detection of infectious pathogens, including Plasmodium spp. However, most malaria-endemic areas, which are often resource-limited, current LAMP methods not feasible diagnosis due to difficulties accurately interpreting results with problems sensitive visualization amplified products, risk contamination resulting from quantity produced. In...
Malaria, dengue fever, and filariasis are three of the most common mosquito-borne diseases worldwide. Malaria lymphatic can occur as concomitant human infections while also sharing mosquito vectors. The overall prevalence health significance malaria have made them top priorities for global elimination control programmes. Pyrethroid resistance in anopheline vectors represents a highly significant problem to Several methods been proposed mitigate insecticide resistance, including rotational...
Mycobacterium tuberculosis (Mtb) infection activates the NLRP3 inflammasome in macrophages and dendritic cells. Much attention has been paid to mechanisms for regulation of against Mtb. However, whether epigenetic participated activation is still little known. Here we showed that was regulated by DNA methylation modification. Mtb promoted inflammatory cytokines expression. promoter cloned subsequently identified Dual-Luciferase Reporter System. The results activity decreased after methylase...
Abstract Although artemisinin combination therapies have succeeded in reducing the global burden of malaria, multidrug resistance deadliest malaria parasite, Plasmodium falciparum , is emerging worldwide. Innovative antimalarial drugs that kill all life-cycle stages parasites are urgently needed. Here, we report discovery compound JX21108 with broad antiplasmodial activity against multiple parasites. was developed from chemical optimization quisinostat, a histone deacetylase inhibitor. We...
Four human B cell lines established by Epstein-Barr viral transformation of cells from a patient with clinical diagnosis Alzheimer's disease (AD) were found to secrete antibodies that react plaques and cerebrovascular blood vessels in AD brain staining profile characteristic beta-amyloid protein (beta-AP) brain. Two these shown be reactive rare plaque normal In studies, immunofluorescence avidin-biotin complex immunoperoxidase methodology used determine antibody reaction, thioflavine S was...
Anopheles sinensis is one of the most abundant vectors malaria and other diseases in Asia. Vector control through use insecticides front line method vector-borne diseases. Pyrethroids are commonly used due to their low toxicity vertebrates repellency. However, extensive has imposed strong selection pressure on mosquito populations for resistance. High levels resistance pyrethroid various mutations haplotypes para sodium channel gene that confers knockdown (kdr) have been detected An....
Sepsis is a life-threatening complication of an infection and remains one the leading causes mortality in surgical patients. Bacteremia induces excessive inflammatory responses that result multiple organ damage. Chronic helminth helminth-derived materials have been found to immunomodulate host immune system reduce inflammation against some allergic or diseases. Schistosoma japonicum cystatin (Sj-Cys) cysteine protease inhibitor regulatory T-cells potential immunomodulatory. The effect Sj-Cys...
Helminths immunomodulate the host immune system by secreting proteins to create an inhibitory environment as a strategy for survival in host. As bystander effect, this balances reduce hypersensitivity allergens or autoantigens. Based on this, helminth therapy has been used treat some allergic autoimmune diseases. tissue-dwelling helminth, Trichinella spiralis infection identified have strong immunomodulatory effects; effective components worm not yet identified. The soluble extracts of T....
Acute respiratory failure due to acute hypoxemia is the major manifestation in severe coronavirus disease 2019 (COVID-19). Rational and effective support crucial management of COVID-19 patients. High-flow nasal cannula (HFNC) has been utilized widely its superiority over other non-invasive techniques. To avoid HFNC intubation delay, key issues are proper patients, timely application improving compliance. It should be noted that elder patients vulnerable for failed HFNC. We applied oxygen...
Vivax malaria is an important public health problem in the Greater Mekong Subregion (GMS), including China-Myanmar border. Previous studies have found that Plasmodium vivax has decreased sensitivity to antimalarial drugs some areas of GMS, but P. unclear Here, we investigate drug profile and genetic variations for two resistance related genes isolates provide baseline information future border.A total 64 clinical collected from border area were assessed ex vivo susceptibility eight by...
Silver nanoparticles (AgNPs) have wide clinical applications because of their excellent antibacterial properties; however, they can cause liver inflammation in animals. Macrophages are among the main cells mediating and also responsible for phagocytosis nanomaterials. The NLRP3 inflammasome is a major mechanism inflammation, its activation both induces cytokine release triggers inflammatory cell death (i.e., pyroptosis). In previous studies, we demonstrated that mitophagy plays protective...