A5100338262- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- MicroRNA in disease regulation
- Systemic Lupus Erythematosus Research
- Pregnancy and preeclampsia studies
- Circular RNAs in diseases
- Cancer, Lipids, and Metabolism
- Metamaterials and Metasurfaces Applications
- Orbital Angular Momentum in Optics
- Advanced Antenna and Metasurface Technologies
- Osteoarthritis Treatment and Mechanisms
- Cancer Immunotherapy and Biomarkers
- Cytokine Signaling Pathways and Interactions
- Parasites and Host Interactions
- Advanced Breast Cancer Therapies
- Cancer-related Molecular Pathways
- Cancer Genomics and Diagnostics
- Cancer, Hypoxia, and Metabolism
- Endometrial and Cervical Cancer Treatments
- Genetic factors in colorectal cancer
- Reproductive tract infections research
- Cholesterol and Lipid Metabolism
- Atherosclerosis and Cardiovascular Diseases
- Neuroendocrine Tumor Research Advances
- Cancer Research and Treatments
Shandong First Medical University
2022-2024
Shandong Tumor Hospital
2022-2024
Zhejiang Cancer Hospital
2024
Bengbu Medical College
2017-2024
Wenzhou Medical University
2017-2024
Ruian People's Hospital
2017-2024
Academy of Medical Sciences
2024
Huazhong University of Science and Technology
2006-2023
Pudong Medical Center
2023
Fudan University
2023
Abstract The Airy beam has attracted considerable research interest owing to the intriguing diffraction‐free, self‐accelerating, and self‐healing properties, hence found numerous applications in photonics. Metasurfaces provide a compact method generate beams, but available generators suffer from issue of narrow bandwidth since they typically rely on resonance principles. Here, hyperbolic metamaterials (HMMs) are proposed address this by taking advantage broadband high birefringence. By...
BACKGROUND Long noncoding RNAs (lncRNAs) are important regulators in human disease, including cancers. LncRNA MIR22HG has been shown to inhibit the progression of endometrial carcinoma, lung cancer, and hepatocellular carcinoma. Its role gastric cancer is unclear. This study investigated effects on cancer. MATERIAL AND METHODS Gastric tissues (n=43) adjacent normal (n=21) were collected. Patients' 5-year overall survival rate was analyzed. Human mucosal cell line (GES-1) lines (MKN-45, AGS,...
Sepsis is a life-threatening complication of an infection and remains one the leading causes mortality in surgical patients. Bacteremia induces excessive inflammatory responses that result multiple organ damage. Chronic helminth helminth-derived materials have been found to immunomodulate host immune system reduce inflammation against some allergic or diseases. Schistosoma japonicum cystatin (Sj-Cys) cysteine protease inhibitor regulatory T-cells potential immunomodulatory. The effect Sj-Cys...
The current understanding of how overall principles translational control govern the embryo-to-adult transition in mammals is still far from comprehensive. Herein we profiled translatomes and transcriptomes six tissues mice at embryonic adult stages presented first report tissue- stage-specific landscape mice. We quantified extent gene expression divergence among different layers, stages, detected significant changes composition function underlying these divergences revealed changing...
Autophagy has been reported to be widely involved in the pathogenesis of osteoarthritis (OA). Increasing evidence suggested important role microRNAs (miRs) progression OA. However, functional miR‑17‑5p OA development remained fully elucidated. First, a mouse model was established and relative level determined using PCR. Safranin O‑fast green staining applied determine cartilage degeneration. TargetScan software dual luciferase reporter assay were potential target genes miR‑17‑5P. measurement...
Abstract Epithelial ovarian cancer (EOC) is a common in gynecological cancers today. It has been found that microRNAs and long‐chain noncoding RNA (lncRNA) regulate the gene transcriptional expression cells. However, it not well understood upstream downstream regulatory molecules of lncRNA HOX antisense intergenic ( HOTAIR ). The effects miR‐200c overexpression on invasion nude mouse tumorigenicity, as snail EOC SKOV3 cells, should be further explored. was detected by reverse transcription...
Abstract Background The incidence rate of cervical cancer is increasing yearly. persistent infection high-risk human papillomavirus (HPV) the main factor leading to cancer. HPV double peak type. This study aimed at analyzing distribution characteristics, rate, and risk age in pre- postmenopausal women. So as provide reference for prevention screening strategy. Methods A retrospective analysis 4614 women who underwent cytology, examination from January 2018 October 2019 healthcare department...
Background. Cytokines play important roles in the development and prognosis of laryngeal cancer (LC). Interleukin-17 (IL-17) from a distinct subset CD4+ T cells may significantly induce cancer-elicited inflammation to prevent tumor immune surveillance. Methods. The expression levels IL-17 were examined among 60 patients with LC. Immunofluorescence colocalization experiments performed verify localization FAS/FASL Hep-2 Tu212 cells. role was determined using siRNA techniques LC cell line....
Background: In recent years, tumor immunotherapy has become a viable treatment option for triple negative breast cancer (TNBC). Among these, immune checkpoint inhibitors (ICIs) have demonstrated good efficacy in advanced TNBC patients with programmed death-ligand 1 (PD-L1) positive expression. However, only 63% of PD-L1-positive individuals showed any benefit from ICIs. Therefore, finding new predictive biomarkers will aid identifying who are likely to this study, we used liquid biopsies and...
The lmo2 gene is a specific oncogene in T-cell leukemia, for its ectopic expression causes both increased pro-T-cell proliferation and differentiation arrest, leading to the onset of leukemia. Notably, DeltaEF1 (also known as ZEB1), member zinc finger-homeodomain family transcription factor, also exhibits crucial function promoting differentiation. In this study, we found that was positively regulated by T-lineage-specific transcriptional regulator GATA3, while ectopically expressed LMO2...
Objective: Atherosclerosis is an arterial occlusive disease with hypercholesterolemia and hypertension as common risk factors. Advanced-stage stenotic plaque, which features inflammation necrotic core formation, the major reason for clinical intervention. Receptor interacting serine/threonine-protein kinase 1 (RIPK1) mediates cell death expressed in atherosclerotic lesions. The role of RIPK1 advanced-stage atherosclerosis unknown. Approach Results: To investigate effect inhibition advanced...
Endometrial carcinoma (EC) remains one of the most prevalent forms cancer to impact female reproductive system, yet mechanisms governing its development and progression are incompletely understood. We, therefore, sought assess relevance SOX8 EC patient prognosis. Array comparative genomic hybridization (aCGH) was performed using samples from 50 patients with EC. Samples were separated based upon whether positive for lymph node metastasis (LN+ LN-, respectively). Based on our initial results,...
Multiple myeloma (MM) is a prevalent hematological malignancy that poses significant challenges for treatment. Dysregulated cholesterol metabolism has been linked to tumorigenesis, disease progression, and therapy resistance. However, the correlation between metabolism-related genes (CMGs) prognosis of MM remains unclear. Univariate Cox regression analysis LASSO were applied construct an overall survival-related signature based on Gene Expression Omnibus database. The was validated using...
Metasurfaces have exhibited considerable capability for generating Airy beams. However, the available plasmonic/dielectric metasurfaces Airy-beam generators low transmission efficiency and/or poor quality of generated beam because they lack amplitude modulation. Hyperbolic metamaterials (HMMs) recently provided an alternative strategy building high-performance meta-devices that are capable flexibly modulating phase, and polarization state light. Here we reveal both propagation phase...
Abstract Genetic analysis for germline mutations of RET proto‐oncogene has provided a basis individual management medullary thyroid carcinoma (MTC) and pheochromocytoma. Most compound have more aggressive phenotypes than single point mutations, but the C634Y/V292M variant in MTC never been reported. Thus, we retrospectively investigated synergistic effect C634Y V292M family members with multiple endocrine neoplasia type 2A. Nine 14 northern Chinese underwent mutation screening using...
Summary Background CDK4/6 inhibitors is highly valued, but the incidence of cardiovascular events (CVAEs) associated with not clear. Methods Eligible CVAEs were extracted from ClinicalTrials.gov registry. A systematic search electronic databases (PubMed, Embase, Cochrane Library, and important meetings) until 3 September 2023 was conducted. disproportionality analysis performed first quarter (Q1) 2013 to Q1 using data FDA Adverse Event Reporting System database. Study heterogeneitywas...
Sepsis is a disease caused by multiple microbial infections resulting in organ failure. Schistosoma japonicum secreted cystatin (Sj-Cys) strong immunomodulator that stimulates M2 macrophages and alleviates inflammatory damage sepsis. To determine whether the therapeutic effect of Sj-Cys on sepsis can be conveyed exosomes released Sj-Cys-stimulated macrophages, RAW264.7 were stimulated with rSj-Cys vitro, obtained from cell culture supernatant ultracentrifugation. was induced BALB/c mice...