A5071315437- Inflammatory mediators and NSAID effects
- Lipoproteins and Cardiovascular Health
- Autoimmune Bullous Skin Diseases
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Blood Coagulation and Thrombosis Mechanisms
- Cancer, Lipids, and Metabolism
- Aortic aneurysm repair treatments
- Infectious Aortic and Vascular Conditions
- Cardiac Ischemia and Reperfusion
- Heart Failure Treatment and Management
- Urticaria and Related Conditions
- Kawasaki Disease and Coronary Complications
- Receptor Mechanisms and Signaling
- Nitric Oxide and Endothelin Effects
- Atherosclerosis and Cardiovascular Diseases
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac Fibrosis and Remodeling
- Acute Myocardial Infarction Research
- Phosphodiesterase function and regulation
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2025
Background: Timely and complete restoration of blood flow is the most effective intervention for patients with acute myocardial infarction. However, efficacy limited by ischemia-reperfusion (MI/R) injury. PDE4 (phosphodiesterase-4) hydrolyzes intracellular cyclic adenosine monophosphate it has 4 subtypes A-D. This study aimed to delineate role PDE4B (phosphodiesterase-4 subtype B) in MI/R Methods: Mice were subjected 30-minute coronary artery ligation, followed 24-hour reperfusion. Cardiac...
Abstract Aims The therapeutic efficacy of coronary revascularization is compromised by myocardial ischemia-reperfusion (MI/R) injury. Higher levels circulating arachidonic acid (AA) are reportedly associated with lower risk cardiovascular disease. cyclooxygenase (COX) pathway metabolizes AA into prostaglandins (PGs) and the platelet-activating thromboxane A2 (TXA2), which inhibited aspirin. We aimed to explore whether or its combination aspirin modulates MI/R injury aspirin-caused gastric...
Psoriasis is an autoimmune inflammatory skin disease, featuring microvascular abnormalities and elevated levels of bradykinin. Contact activation Factor XII can initiate the plasma kallikrein-kinin cascade, producing inflammation angioedema. The role in psoriasis unknown.
BACKGROUND: Abdominal aortic aneurysm (AAA) is a chronic vascular inflammatory disease without effective medications. PCSK9 (proprotein convertase subtilisin/kexin 9), serine protease from the proprotein family, has recently been associated with AAA in human genome-wide association studies. However, its role unknown. METHODS: Transcriptional and histological expression of was examined tissues healthy controls. The impact deletion inhibition on formation assessed mice hyperlipidemia Ang II...
Heart failure with reduced ejection fraction (HFrEF) is a major consequence of myocardial infarction (MI). The microsomal prostaglandin E synthase-1 (mPGES-1)/PGE2 pathway has been shown to constrain reperfusion injury after acute ischaemia. However, it unknown whether pharmacological inhibition mPGES-1, target lower risk thrombosis compared selective cyclooxygenase-2, affects chronic cardiac remodelling MI.Mice were subjected left anterior descending coronary artery ligation, followed by...
Factor XII (FXII) is the zymogen of plasma protease FXIIa that activates intrinsic coagulation pathway and kallikrein kinin-system. The role FXII in inflammation has been obscure. Here, we report a single-domain antibody (nanobody, Nb) fused to Fc region human immunoglobulin (Nb-Fc) recognizes conformation-dependent manner interferes with formation. Nb-Fc treatment inhibited arterial thrombosis male mice without affecting hemostasis. In mouse model extracorporeal membrane oxygenation (ECMO),...
Objective: Atherosclerosis is an arterial occlusive disease with hypercholesterolemia and hypertension as common risk factors. Advanced-stage stenotic plaque, which features inflammation necrotic core formation, the major reason for clinical intervention. Receptor interacting serine/threonine-protein kinase 1 (RIPK1) mediates cell death expressed in atherosclerotic lesions. The role of RIPK1 advanced-stage atherosclerosis unknown. Approach Results: To investigate effect inhibition advanced...