A5002299459- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Tracheal and airway disorders
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Mobile Health and mHealth Applications
- Glaucoma and retinal disorders
- Lung Cancer Research Studies
- Connexins and lens biology
- Salivary Gland Tumors Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- Immunotherapy and Immune Responses
- Digital Mental Health Interventions
- MicroRNA in disease regulation
- T-cell and Retrovirus Studies
- Intraocular Surgery and Lenses
- Herpesvirus Infections and Treatments
- Ion Transport and Channel Regulation
- Circular RNAs in diseases
- Histiocytic Disorders and Treatments
- interferon and immune responses
- 3D Shape Modeling and Analysis
- Silk-based biomaterials and applications
- Advanced Neural Network Applications
- Heme Oxygenase-1 and Carbon Monoxide
- Family and Patient Care in Intensive Care Units
Xuzhou Medical College
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Hangzhou Vocational and Technical College
2024
State Grid Corporation of China (China)
2024
Xuzhou No.1 People's Hospital
2024
Wuxi Fourth People's Hospital
2012-2023
Jiangnan University
2018-2023
Wuxi No.2 People's Hospital
2013-2017
Shandong Agricultural University
2013-2016
Wuxi People's Hospital
2003-2015
Background The application of telemedicine in home pulmonary rehabilitation interventions for the management patients with chronic obstructive disease (COPD) has achieved promising results. Objective This study aimed to develop a WeChat official account (Pulmonary Internet Explorer Rehabilitation [PeR]) based on social media. It further evaluated effect PeR quality life, symptoms, and exercise self-efficacy COPD. Methods functional modules were developed by multidisciplinary team according...
microRNAs are small, non-coding RNAs that contribute into various biological processes during cancer progression. However, the potential role of miR-489 in development Non-Small Cell Lung Cancer (NSCLC) is not demonstrated. In present study, was down-regulated both tumor tissues and cells. Inhibition promoted cells invasion by using an assay. Furthermore, could regulate SUZ12 as shown luciferase reporter Western blot assays. Aberrant expression molecular changes (E-cadherin, N-cadherin,...
The genetic diversity of avian leukosis virus subgroup J (ALV-J) is determined not only by the env gene, but also its 3' UTR and LTR. They all play important roles in extending host range tumour development. In present study, one ALV-J strain (ZB110604-6) from Black-Bone Silky Fowl (BSF) three strains (ZB110604-3/4/5) grey partridge (GP), which bore multiple tumours breed house Farm A, were demonstrated their to GP, while two other (LC110515-3/4) BSF B could infect embryo fibroblast GP. a...
Aberrant expression of B7-H4 occurs across a broad spectrum human cancers. The aim this study was to investigate the key role during tumorigenesis and metastasis lung cancer. Our data showed that shRNA-mediated disruption markedly inhibited tumor cell proliferation, invasion migration, increased apoptosis arrested cycle at G0/G1. These changes were accompanied by marked increase in Bax caspase-3/caspase-8, but decrease Bcl-2, cyclinD1 activation AKT. In addition, our led growth...
Non-small cell lung cancer (NSCLC) patients treated with first-generation epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) almost always acquire resistance, and the development of novel techniques analyzing circulating tumor DNA (ctDNA) have made it possible for liquid biopsy to detect genetic alterations from limited amount less invasiveness. While a large EGFR exon 21 p.Thr790 Met (T790M) benefited osimertinib treatment, acquired resistance osimertinb has subsequently...
BACKGROUND In the present study, we aimed to investigate effects of sinomenine (SIN) on chronic intermittent hypoxia (CIH)- induced lung injury in rats, and explore underlying mechanisms. MATERIAL AND METHODS To perform investigation, a CIH rat model was established. ELISA assay applied detect level inflammatory cytokines. Oxidative stress bio-markers (MDA, SOD, CAT) were determined tissues. addition, expression NADPH oxidase 2 (Nox2) analyzed by Western blotting qRT-PCR, respectively....
Avian leukosis virus (ALV) is the most common oncogenetic retrovirus that emerges spontaneously as a result of recombination between exogenous viruses, viruses and endogenous non-homologous cellular genes. In present study, two natural recombinant avian (rALVs) (LC110515-5 LC110803-5) carrying subgroup C gp85 gene, E gp37 J 3'UTR 3'LTR were isolated from different lines layer flocks, Black-bone silky fowl (BSF) commercial chicken, suffered myeloid leukosis. Although tumours not observed in...
B7-H6 is a novel co-stimulatory ligand that detected in most malignancies. However, the significance of small cell lung cancer (SCLC) remains unknown.B7-H6 expression was analyzed by immunohistochemistry (IHC) 103 collected SCLC samples, and its association with clinicopathological characteristics prognosis analyzed. The 2-year survival rates were also investigated.B7-H6-positive staining 58 (56.31%) cases, found to be localized mainly intracellular space SCLC. Weak tissues observed 4 (8%)...
Factor XII (FXII) is the zymogen of plasma protease FXIIa that activates intrinsic coagulation pathway and kallikrein kinin-system. The role FXII in inflammation has been obscure. Here, we report a single-domain antibody (nanobody, Nb) fused to Fc region human immunoglobulin (Nb-Fc) recognizes conformation-dependent manner interferes with formation. Nb-Fc treatment inhibited arterial thrombosis male mice without affecting hemostasis. In mouse model extracorporeal membrane oxygenation (ECMO),...
Pulmonary epithelioid hemangioendothelioma (P-EHE) is a rare disease. Thus far, consensus on standard treatment for P-EHE has not been established given its low incidence worldwide. Apatinib combined with chemotherapy doxorubicin/cyclophosphamide used as an effective combination human malignancies. However, the efficacy of this reported in cases.We present case 64-year-old woman chest tightness, cough, and pain. Computed tomography showed multiple unresectable pulmonary nodules. She had...
BACKGROUND:Obstructive sleep apnea (OSA) is associated with many cardiovascular disorders. Intermittent hypoxia (IH) a key pathological hallmark of OSA. This study was conducted to evaluate the potential therapeutic effects and mechanisms adiponectin (APN) on IH induced human adult cardiac myocytes (HACMs) injury. MATERIAL AND METHODS:HACMs were exposed normoxia or (1% 21% O₂) using novel cell culture bio-reactor gas-permeable membranes. Cell viability detected by Counting Kit-8 assay....
Avian leukosis virus subgroup J (ALV-J) is an oncogenic retrovirus which causes immunosuppression and neoplasia in meat-type egg-type chickens. ALV-J infects host cells via specific interaction between the viral Env cell surface receptor -chicken sodium hydrogen exchanger type 1 (chNHE1). NHE1 involved altering cellular pH playing a critical role tumorigenesis. However, little known about other relationship chNHE1.In infected DF-1 cells, mRNA level of chNHE1 was up-regulated with...
This paper proposes a 3D object detection algorithm that combines dynamic convolution with adaptive pooling as extraction (PAC-PAPRCNN). The is divided into two stages. first stage generates feature proposals in bottom-up manner, and the second refines generated stage. Firstly, stage, new type of used to adaptively learn location features points. To classify foreground background points layer, theory applied. Meanwhile, extracted are regression boxes one by one, then box best score selected...
<title>Abstract</title> <bold>Objective</bold>: To effectively avoide the occurrence of Argentinian flag sign during process continuous, circular, and centered anterior capsulotomy (CCC) on capsule in cortically liquefied intumescent cataracts <bold>Methods:</bold> Preoperative examinations including slit-lamp examination, ocular A-scan ultrasonography, UBM were conducted 61 patients with cataracts. Cases selected after staining indocyanine green, chamber air bubble technique was used to...
We conducted in this paper a regression analysis of factors associated with acute radiation pneumonia due to therapy for lung cancer utilizing cluster explore the predictive effects clinical and dosimetry on grade ≥2 further refine effect ratio volume primary foci lobes which they are located pneumonia, that clinically effective predicting occurrence pneumonia. This will provide basis better guiding therapy, reducing improving safety radiotherapy. Based characteristics selected surveillance...
Background Jiangsu Province, China, is highly developed economically and culturally, has a high prevalence of lung cancer. We aimed to evaluate the diagnostic procedures, genetic aberration analysis status, first‐line treatment models cancer in Province. Methods Lung patients diagnosed 2016 at 22 tertiary care hospitals were evaluated. Demographic characteristics, tumor histology, staging, family history cancer, auxiliary examinations, testing, collected on discharge. Diagnostic data...
Background: B7-H4, a member of the B7 family, is detected in various cancers and closely related to tumor development prognosis. However, little known about clinical value B7-H4 small cell lung cancer (SCLC). Methods: Immunohistochemical analysis was carried out on 103 SCLC specimens. The relationship between staining major parameters analyzed, two-year survival rates were investigated by chi-square test. Results: Only 5.83% specimens tested positive for B7-H4. membrane cytoplasm cells. In...
Objective To investigate the diagnostic value of transbronchial needle aspiration (TBNA) and biopsy(TBB) in central lung cancer.Methods Retrospectively analyzed data 150 patients with cancer who underwent TBNA followed by TBB our hospital from January 2011 to October 2012.Results Among cancer,33 cases had intracavity mass.Thirtythree (100％) were confirmed 32 (97.0％) TBNA.There was no statistically significant difference between diagnosis TBNA(P =0.90).There 26 simple stenosis,among which 1...
Objective To evaluate the application value of ultrathin fibreoptic bronchoscopy in diagnosis peripheral lung cancer.Methods The data 32 cancer patients who had performed were retrospectively analyzed.They firstly diagnosed by conventional bronchoscope and found nothing.Secondly,ultrathin been done to them.Results 25 times biopsy,40 brush biopsy.16 identified cancer,eight cases pulmonary adenocarcinoma,four squamous carcinoma,two small cell cancer,two unclassified cancer,the positive rate...
Objective To explore the role of autofluorescence bronchoscopy in lung cancer operation and meaning choice mode.Methods retrospectively analyze 32 non-small cell patients.Before operation,white light (WLB) (AFB) had been done routinely.Compared different invasive tumor conditions by WLB AFB,operation modes were decided edge which proved biopsy pathology.Results In cases,19 cases underwent pulmonary lobectomy.One case carinal resection reconstruction.8 sleeve lobectomy.4 other therapy because...