A5043052233- Kidney Stones and Urolithiasis Treatments
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Trace Elements in Health
- Selenium in Biological Systems
- MicroRNA in disease regulation
- RNA modifications and cancer
- Alcohol Consumption and Health Effects
- Autophagy in Disease and Therapy
- Cancer-related Molecular Pathways
- Birth, Development, and Health
- Environmental Toxicology and Ecotoxicology
- Ferroptosis and cancer prognosis
- Gout, Hyperuricemia, Uric Acid
- Pregnancy and preeclampsia studies
- Heme Oxygenase-1 and Carbon Monoxide
- Cancer Immunotherapy and Biomarkers
- Heavy metals in environment
- Cancer-related gene regulation
- Connexins and lens biology
- Arsenic contamination and mitigation
- Pancreatitis Pathology and Treatment
- RNA Research and Splicing
- Epigenetics and DNA Methylation
- Porphyrin Metabolism and Disorders
Huazhong University of Science and Technology
2019-2025
Tongji Hospital
2016-2025
Institute of Oceanology
2025
Analysis and Testing Centre
2024-2025
Kunming University of Science and Technology
2024-2025
Huazhong Agricultural University
2021-2024
Hunan University of Humanities, Science and Technology
2023-2024
Beijing University of Chinese Medicine
2024
Shanxi Medical University
2024
Qilu Hospital of Shandong University
2021-2023
The quality control of skeletal muscle is a continuous requirement throughout the lifetime, although its functions and present as declining trend during aging process. Dysfunctional or deficient autophagy excessive apoptosis may contribute to atrophy senescent muscle. Spermidine, natural polyamine, can be involved in important cellular for lifespan extension stress resistance several model organisms through activating autophagy. Similarly, autophagic responses exercise have also been...
The underlying molecular mechanisms for aging-related neurodegenerative diseases such as Alzheimer's disease (AD) are not fully understood. Currently, growing evidences have revealed that microRNAs (miRNAs) involved in aging and diseases. up-regulation of miR-34a has been reported to be associated with diseases, thus it should a promising therapeutic target. Ampelopsin, also called dihydromyricetin (DHM), natural flavonoid from Chinese herb Ampelopsis grossedentata, possess multiple...
Calcium oxalate (CaOx) crystal can trigger kidney injury, which contributes to the pathogenesis of nephrocalcinosis. The phenotypes infiltrating macrophage may impact CaOx-mediated inflammatory injury as well deposition. How aryl hydrocarbon receptor (AhR) regulates inflammation and polarization is understood; however, how it modulates CaOx nephrocalcinosis remains unclear. Methods: Mice were intraperitoneally injected with glyoxylate establish model or without treatment AhR activator...
The mechanism of cell immortalization human breast epithelial cells leading to neoplastic transformation is not clear. isolation and characterization a spontaneously immortalized line, MCF-10F, have provided valuable tool identify genes involved in this process. Using the technique differential display, we identified seven cDNA bands differentially displayed MCF-10F when compared with mortal S130 from which was originated. One these isolated cloned. Sequence analysis revealed 99% homology...
BackgroundIntrarenal calcium oxalate (CaOx) crystals induce inflammation and kidney tubular cell injury, which are processes that involve TLR4/NF-κB signalling. A recent genome-wide gene expression profile analysis of Randall's plaques in CaOx stone patients revealed the long noncoding RNA H19 was significantly upregulated. However, to date, its role stones has not been reported.MethodA Gene Expression Omnibus (GEO) dataset utilized analyse profiles. Luciferase reporter, Western blotting,...
Intrarenal calcium oxalate (CaOx) crystals induce renal tubular epithelial cells (TECs) injury and inflammation, which involve Toll-like receptor 4 (TLR4)/interferon regulatory factor 1 (IRF1) signaling. Additionally, infiltrating macrophages (Mϕs) might influence intrarenal CaOx CaOx-induced injury. Although the roles of nuclear erythroid 2-related 2 (Nrf2) in regulating inflammation macrophage polarization are well characterized, its potential mechanisms nephrocalcinosis remain undefined....
Renal tubular cell injury induced by calcium oxalate (CaOx) is a critical initial stage of kidney stone formation.Theaflavin (TF) has been known for its strong antioxidative capacity; however, the effect and molecular mechanism TF against oxidative stress caused CaOx crystal exposure in kidneys remains unknown.To explore potential function on renal deposition underlying mechanisms, experiments were conducted using nephrocalcinosis mouse model established glyoxylate intraperitoneal injection,...
Nano‑selenium (SeNPs) is a red elemental selenium with extremely small particles, which can be absorbed by the body and has biological activity. Currently, most commonly used synthetic methods for SeNPs are biosynthesis chemical synthesis. In this study, YC-3-SeNPs were biosynthesized strain of yak-gut Bacillus cereus YC-3, meanwhile, CST-SeNPs chemically synthesized encapsulated chitosan. A series characterizations proved that spherical particles excellent stability, both have an ability to...
microRNAs are small, non-coding RNAs that contribute into various biological processes during cancer progression. However, the potential role of miR-489 in development Non-Small Cell Lung Cancer (NSCLC) is not demonstrated. In present study, was down-regulated both tumor tissues and cells. Inhibition promoted cells invasion by using an assay. Furthermore, could regulate SUZ12 as shown luciferase reporter Western blot assays. Aberrant expression molecular changes (E-cadherin, N-cadherin,...
Interaction of pioglitazone (PGZ) and macrophages (Mps) in renal crystal formation remains unclear. In the present study, we investigated possible mechanisms involved with Mps PGZ suppressing formation. Crystal mouse kidney was detected using polarized light optical microscopy Pizzolato staining. Gene expression by Western blot analysis, quantitative RT-PCR, immunohistochemistry, immunofluorescence, ELISA. Mp phenotypes were identified flow cytometric analysis. Cell apoptosis TUNEL assay,...
Long non-coding RNAs (lncRNAs) have been considered as biomarkers for the carcinogenesis and development of various cancers. However, prognostic significance lncRNAs in renal cell carcinoma (RCC) remains unclear. This study aimed to determine predictive ability clear RCC (ccRCC). Among cohort kidney (KIRC) The Cancer Genome Atlas (TCGA), 525 patients were enrolled our study. Expression based on RNAseq was obtained from TCGA. Kaplan-Meier analysis a Cox proportional hazards regression model...
The roles of the lncRNA X inactive specific transcript (XIST) in many diseases, including cancers and inflammatory sickness, have been previously elucidated. However, renal calculus remained poorly understood. In this study, we revealed potential effects XIST on kidney stones that were exerted via response oxidative stress mechanisms. We established a glyoxylate-induced calcium oxalate (CaOx) stone mouse model exposed HK-2 cells to monohydrate (COM). interactions among XIST, miR-223-3p,...
Background/objective While Physical Literacy has been highlighted as a determinant in health recent study, there is dearth of studies examining its effect on physical health, and little the way empirical data linking to outcomes. Accordingly, further research needed clarify mechanisms by which affects health. The purpose this study was verify role medical students’ Health-related quality life well explore chain mediating Activity Subjective Well-being it. Methods This utilized...
Introduction: The purpose of this study was to identify the chemical components Massa Medicata Fermentata (MMF) in different fermentation methods, analyze its regulatory effects on gastrointestinal propulsion and intestinal flora mice with food accumulation, further explore mechanism action treatment dyspepsia. Methods: compositions three kinds MMF were identified using UPLC-Q- Exactive Orbitrap mass spectrometer. A model spleen deficiency accumulation established. gastric emptying rate...