A5087747599- Inflammatory mediators and NSAID effects
- Rheumatoid Arthritis Research and Therapies
- Fatty Acid Research and Health
- NF-κB Signaling Pathways
- Inflammatory Myopathies and Dermatomyositis
- Infant Nutrition and Health
- Eicosanoids and Hypertension Pharmacology
- Estrogen and related hormone effects
- Birth, Development, and Health
- Systemic Lupus Erythematosus Research
- Breastfeeding Practices and Influences
- Neuroblastoma Research and Treatments
- Peroxisome Proliferator-Activated Receptors
- Nicotinic Acetylcholine Receptors Study
- Vagus Nerve Stimulation Research
- Neuropeptides and Animal Physiology
- T-cell and B-cell Immunology
- Cytokine Signaling Pathways and Interactions
- Adipose Tissue and Metabolism
- Neonatal Respiratory Health Research
- Receptor Mechanisms and Signaling
- Cancer, Lipids, and Metabolism
- Monoclonal and Polyclonal Antibodies Research
- Cancer, Hypoxia, and Metabolism
- Cell Adhesion Molecules Research
Karolinska University Hospital
2015-2024
Karolinska Institutet
2015-2024
Izhevsk State Medical Academy
2022
University of Gothenburg
1998-2015
Nobel Foundation
2013
Stockholm University
2013
University Health Network
2008-2012
University of Toronto
2008-2012
Toronto General Hospital
2008-2012
Center for Systems Biology
2012
Significance Cancer-related inflammation promotes progression and therapy resistance in tumors of adulthood. Knowledge concerning the significance childhood malignancies has been limited. Neuroblastoma is an embryonal tumor early with poor prognosis despite intensified therapy, biological understanding necessary to develop novel therapies. We found high-risk neuroblastoma, particular therapy-resistant subset chromosome 11q-deletion, be inflammatory driven characterized by high expression...
Abstract The inflamed rheumatic joint is a highly heterogeneous and complex tissue with dynamic recruitment expansion of multiple cell types that interact in multifaceted ways within localized area. Rheumatoid arthritis synovium has primarily been studied either by immunostaining or molecular profiling after homogenization. Here, we use Spatial Transcriptomics, where tissue-resident RNA spatially labeled situ barcodes transcriptome-wide fashion, to study local interactions at the site...
Pharmacological inhibition of cyclooxygenase-2 increases the risk myocardial infarction (MI) and stroke. Microsomal prostaglandin (PG) E(2) synthase-1 (mPGES-1), encoded by Ptges gene, functions downstream from in inducible PGE(2) biosynthetic pathway. We caused acute MI Ptges(+/+) Ptges(-/-) mice to define role mPGES-1 cardiac ischemic injury.Twenty-eight days after MI, develop more left ventricular (LV) dilation, have worse LV systolic diastolic function, higher end-diastolic pressure than...
Abstract Introduction It was previously shown that lipoxygenase (LO) pathways are important in the rheumatoid arthritis (RA) inflammatory process and synovial fluid from RA patients contains high amounts of leukotrienes. We therefore aimed to investigate 5-LO 15-LO-1 expression pattern ostheoarthritis (OA) tissue study effect intraarticular glucocorticoid (GC) therapy on enzyme expression. Methods Expression LOs evaluated by immunohistochemistry OA biopsies. Cellular localization these...
Objective Endurance exercise demonstrates beneficial effects in polymyositis/dermatomyositis (PM/DM); however, the molecular of on skeletal muscle are incompletely understood. We undertook this controlled pilot study to investigate a 12‐week endurance training program profile patients with established PM/DM compared nonexercised control group PM/DM. Methods Fifteen (7 and 8 group) paired baseline follow‐up biopsy samples were included. Messenger RNA expression profiling, mass...
Abstract Lately it has become possible to analyze transcriptomic profiles in tissue sections with retained cellular context. We aimed explore synovial biopsies from rheumatoid arthritis (RA) and spondyloarthritis (SpA) patients, using Spatial Transcriptomics (ST) as a proof of principle approach for unbiased mRNA studies at the site inflammation these chronic inflammatory diseases. Synovial affected joints were studied ST. The transcriptome data was subjected differential gene expression...
Despite recent progress in diagnosis and treatment, survival for children with high-risk metastatic neuroblastoma is still poor. Prostaglandin E2 (PGE2)-driven inflammation promotes tumor growth, immune suppression, angiogenesis resistance to established cancer therapies. In neuroblastoma, cancer-associated fibroblasts (CAFs) residing the microenvironment are primary source of PGE2. However, clinical targeting PGE2 current non-steroidal anti-inflammatory drugs or cyclooxygenase inhibitors...
B cells play a significant role in established Rheumatoid Arthritis (RA). However, it is unclear to what extent differentiated are present joint tissue already at the onset of disease. Here, we studied synovial biopsies (n = 8) captured from untreated patients time diagnosis. 3414 index-sorted underwent RNA sequencing and paired pieces were subjected spatial transcriptomics 4). We performed extensive bioinformatics analyses dissect local cell composition. Select plasma immunoglobulin...
Oligodendrocyte-lineage cells, including NG2 glia, undergo prominent changes in various neurodegenerative disorders. Here, we identify a neuroprotective role for glia against prion toxicity. were activated after infection cerebellar organotypic cultured slices (COCS) and brains of prion-inoculated mice. In both model systems, depletion exacerbated prion-induced neurodegeneration accelerated pathology. Loss enhanced the biosynthesis prostaglandin E2 (PGE2) by microglia, which augmented...
Abstract The newborn has an immune system, very limited in size at birth and its postnatal expansion maturation takes time. In the meantime transplacental IgG antibodies from mother play important role for protection of infant. However, these act tissues induce inflammation are energy‐consuming. contrast, milk secretory IgA stop microbes already on mucosa preventing infection, tissue engagement energy loss. addition, contains many protective factors such as lactoferrin oligosacharides...
Abstract Objective Microsomal prostaglandin E synthase 1 (mPGES‐1) catalyzes the formation of PGE 2 from cyclooxygenase‐derived PGH . PGES‐1 is induced by proinflammatory cytokines and strongly linked to conditions that result in high biosynthesis. contributes pathogenesis rheumatoid arthritis (RA), acting as a mediator inflammation promoting bone destruction. Induction mPGES‐1 synoviocytes has been demonstrated vitro, indicating an important role RA pathogenesis. Recent studies using...
The supply of polyunsaturated fatty acids (PUFA) is important for optimal fetal and postnatal development. We have previously shown that leptin levels in suckling rats are reduced by maternal PUFA deficiency. In the present study, we evaluated effect dietary intake (n-3) (n-6) on content rat milk serum pups. For last 10 days gestation throughout lactation, were fed an isocaloric diet containing 7% linseed oil (n-3 diet), sunflower (n-6 or soybean (n-6/n-3 diet). Body weight, body length,...
Epidemiological studies in humans have shown that perinatal nutrition affects health later life. We previously the ratio of n-6 to n-3 polyunsaturated fatty acids (PUFA) maternal diet serum leptin levels and growth suckling pups. The aim present study was investigate long-term effects various ratios dietary PUFA during period on leptin, insulin, triacylglycerol, as well body adult offspring. During late gestation throughout lactation, rats were fed an isocaloric containing 7 wt% fat, either...
The cholinergic anti-inflammatory pathway (CAP) primarily functions through acetylcholine (ACh)-alpha7 nicotinic receptor (α7nAChR) interaction on macrophages to control peripheral inflammation. Interestingly, ACh can also bind α7nAChRs microglia resulting in neuroprotective effects. However, effects astrocytes remain elusive. Here, we investigated the of nicotine, an agonist, cytokine and cholinesterase production immunocompetent human stimulated with interleukin 1β (IL-1β) vitro. In...
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by synovial inflammation and joint destruction. Cell-derived small extracellular vesicles (sEV) mediate cell-to-cell communication in the microenvironment carrying microRNAs (miRs), class of non-coding RNAs. Herein, we report that sEV from fluid promote osteoclast differentiation which attributed to high levels miR-574-5p. Moreover, demonstrate for first time enhanced maturation mediated Toll-like receptor (TLR) 7/8...