Background and purpose - Recent advances in artificial intelligence (deep learning) have shown remarkable performance classifying non-medical images, the technology is believed to be next technological revolution. So far it has never been applied an orthopedic setting, this study we sought determine feasibility of using deep learning for skeletal radiographs. Methods We extracted 256,000 wrist, hand, ankle radiographs from Danderyd's Hospital identified 4 classes: fracture, laterality, body...

Background and purpose The effects of patient-related technical factors on the risk revision due to dislocation after primary total hip arthroplasty (THA) are only partly understood. We hypothesized that increasing femoral head size can reduce this risk, lateral surgical approach is associated with a lower than posterior minimally invasive approaches, gender diagnosis influence dislocation.Patients methods Data 78,098 THAs in 61,743 patients performed between 2005 2010 were extracted from...

With the increased clinical interest in metal-on-metal and ceramic-on-ceramic total-hip replacements (THRs), objective of this hip simulator study was to identify relative wear ranking three bearing systems, namely CoCr-polyethylene (M-PE), CoCr-CoCr (M-M) (C-C). Volumetric rates were used as method comparison. The seven THR groupings included one M-PE study, two M-M studies four C-C studies. Special emphasis given defining ‘run-in’ phase accelerated that rigid-on-rigid bearings generally...

Background and purpose Our knowledge of frequency foot involvement in rheumatoid arthritis (RA) is still often based on a study from Finland 1956. Great changes the treatment RA may have led to different situation. We investigated distribution joint patients today, with special attention given feet subjective walking ability.

Background and purpose Revision total hip arthroplasty (THA) due to recurrent dislocations is associated with a high risk of persistent instability. We hypothesized that the use dual-mobility cups would reduce re-revision dislocation after revision THA.Patients methods 228 THA cup revisions (in patients) performed employing specific (Avantage) were identified in Swedish Hip Arthroplasty Register. Kaplan-Meier survival analysis was as primary endpoint for any reason secondary endpoint. Cox...

In a 3-year prospective randomized trial, the prognostic value of osteoporosis in terms predicting healing complications due to implant failures or loss fracture reduction has been studied 113 patients with inter-trochanteric hip fractures treated either sliding screwplate Ender nailing. According Barnet and Nordin's index, 66 were considered have moderate severe osteoporosis. There no differences between without as regards number collapse varus > 10 degrees, redislocation mm, compression...

AbstractAseptic loosening due to osteolysis in total hip replacement has been related wear debris released from prosthetic components. Retrospective long-term observations of patients with the metal-on-metal prosthesis shown survivorship and good mechanical performance. Thus, new modified introduced on market. Historical clinical data 1 st generation may not be relevant for 2nd prosthesis. Therefore, preclinical testing must conducted before evaluation.We assessed tribological performance...

Background and purpose There is a lack of national epidemiological data on the characteristics patients with tibial shaft fractures. We therefore analyzed Swedish fractures in this nationwide population study based from 1998 through 2004.Methods Data all were extracted National Hospital Discharge Register.Results identified 10,627 hospital admissions for fractures, corresponding to an annual incidence rate 17 per 100,000 person‐years (pyr). The number decreased by 12% during period...

We hypothesized that an ultra-short stem would load the proximal femur in a more physiological way and could therefore reduce adaptive periprosthetic bone loss known as stress shielding.51 patients with primary hip osteoarthritis were randomized to total arthroplasty (THA) either or conventional tapered stem. The endpoint was change mineral density (BMD), measured dual-energy x-ray absorptiometry (DXA), Gruen zones 1 7, two years after surgery. Secondary endpoints BMD entire region, i.e....

Background and purpose — Postoperative periprosthetic femoral fracture (PPF) after hip arthroplasty is associated with considerable morbidity mortality. We assessed the incidence characteristics of fractures in a consecutive cohort elderly patients treated cemented, collarless, polished tapered stem (CPT). Patients methods In this single-center prospective study, we included 1,403 hips 1,357 (mean age 82 (range 52–102) years, 72% women) primary osteoarthritis (OA) or neck (FNF) as indication...

Abstract Objective Microsomal prostaglandin E synthase 1 (mPGES‐1) catalyzes the formation of PGE 2 from cyclooxygenase‐derived PGH . PGES‐1 is induced by proinflammatory cytokines and strongly linked to conditions that result in high biosynthesis. contributes pathogenesis rheumatoid arthritis (RA), acting as a mediator inflammation promoting bone destruction. Induction mPGES‐1 synoviocytes has been demonstrated vitro, indicating an important role RA pathogenesis. Recent studies using...

It is difficult to assess the orientation of acetabular component on routine radiographs. We present a method for determining spatial after total hip arthroplasty (THA) using computed tomography.Two CT-scans, 10 min apart, were obtained from each patients THA. Using locally developed software, two independent examiners measured in relation pelvis. The measurements repeated one week. To be patient position during scanning, involved steps. Firstly, 3D volumetric image pelvis was brought into...

Abstract Sensory neuropeptide involved in local bone turnover is known, but poorly understood. In the present study, we analyze occurrence of neuronal CGRP during healing and modeling straight angular tibial fractures 74 rats. Bone was assessed by radiography reinnervation semi‐quantitative immunohistochemistry method at fracture site between 1–12 weeks postfracture. The regenerating nerve fibers containing were observed callus as well close proximity to chondrocytes, with woven both already...

Objectives. To describe the overall use and temporal trends in orthopaedic upper limb surgery associated with RA on a nation wide basis Sweden between 1998 2004.

Background and purpose — Total hip replacement (THR) is the preferred method for active lucid elderly patient with a displaced femoral neck fracture (FNF). Controversy still exists regarding use of cemented or uncemented stems in these patients. We compared effectiveness safety between modern cemented, hydroxyapatite-coated stem patients 65–79 years age who were treated THR FNF.Patients methods In single-center, single-blinded randomized controlled trial, we included 69 patients, mean 75...

Background — While age is a common confounder, its impact on health-related quality of life (HRQoL) after total hip replacement uncertain. This could be due to improper statistical modeling in previous studies, such as treating linear variable or by using categories. We hypothesized that there non-linear association between and HRQoL. Methods selected nationwide cohort from the Swedish Hip Arthroplasty Register patients operated with replacements primary osteoarthritis 2008 2010. For...

Forty-three patients with scaphoid pseudarthrosis were surgically treated using the Matti-Russe technique. Twenty-seven examined seven to 17 years after surgery (mean, 12 years). The interval between trauma and operation of was 40 months. Before operation, all unable do any work because pain. Fracture healing observed in 22 cases (81%). Radiocarpal osteoarthrosis present 18 cases, compared eight before operation. Radial deviation extension impaired, pronation supination unaffected, healthy...

In rheumatoid arthritis (RA), pain and joint destruction are initiated propagated by the production of proinflammatory mediators. Synthesis these mediators is regulated transcription factor NF-kappaB, which controlled ubiquitin proteasome system (UPS). The present study explored effects inhibitor MG132 on inflammation, pain, destruction, expression sensory neuropeptides as markers neuronal response in a rat model arthritis.Arthritis was induced rats injection heat-killed Mycobacterium...

Osteoarthritis is a degenerative joint disease with pain and loss of function as major pathological features. Recent studies show that proteasome inhibitors reduce in various conditions. We evaluated the effects MG132, reversible inhibitor on destruction rat model osteoarthritis. was induced by intraarticular injection monosodium iodoacetate into knee. Knee stiffness scored nociception mechanical pressure applied to respective hind paw. assessed radiological histological analyses. Expression...

Background and purpose Modular cementless revision prostheses are being used with increasing frequency. In this paper, we review risk factors for the outcome of Link MP stem report implant survival compared to conventional cemented long-stem hip arthroplasties. Patients methods We data recorded in Swedish Hip Arthroplasty Register. 812 consecutive revisions (mean follow-up time 3.4 years) a control group 1,073 long stems 4.2 were included. Kaplan-Meier analysis was determine survival. The...