A5101480338- Breast Cancer Treatment Studies
- RNA Interference and Gene Delivery
- HER2/EGFR in Cancer Research
- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- MicroRNA in disease regulation
- Advanced biosensing and bioanalysis techniques
- Cancer Treatment and Pharmacology
- Advanced Breast Cancer Therapies
- Circular RNAs in diseases
- Breast Lesions and Carcinomas
- Cancer-related gene regulation
- Viral-associated cancers and disorders
- Molecular Sensors and Ion Detection
- PI3K/AKT/mTOR signaling in cancer
- RNA modifications and cancer
- TGF-β signaling in diseases
- Acupuncture Treatment Research Studies
- Virus-based gene therapy research
- Complementary and Alternative Medicine Studies
- Cancer Mechanisms and Therapy
- Sphingolipid Metabolism and Signaling
- Mechanisms of cancer metastasis
- Extracellular vesicles in disease
- Analytical Chemistry and Sensors
Ministry of Education of the People's Republic of China
2024-2025
Peking University
2021-2025
Peking University Third Hospital
2024-2025
Spinal Research
2025
Guangdong Medical College
2011-2024
Qinghai University Affiliated Hospital
2021-2024
China Medical University
2004-2024
Qinghai University
2024
Guangzhou Medical University
2023-2024
Nanjing University of Science and Technology
2021-2023
To develop biocompatible nanofibrous membranes for wound healing, we investigated the coelectrospinning of two proteins (collagen and zein) in aqueous acetic acid solution. It was found that combination zein could improve electrospinnability collagen. For resultant electrospun membrane, its fiber diameter, surface wettability, mechanical, vitro degradable properties as well cell adhesive ability be modulated by change collagen/zein blending ratio. Moreover, berberine drug incorporated situ...
Abstract Metformin, a widely implemented anti-diabetic drug, exhibits potent anticancer efficacies. Herein polymeric construction of PolyMetformin (PolyMet) is successfully synthesized through conjugation linear polyethylenimine (PEI) with dicyandiamide. The delocalization cationic charges in the biguanide groups PolyMet reduces toxicity PEI both vitro and vivo . Furthermore, polycationic properties permits capture siRNA into core-membrane structured lipid-polycation-hyaluronic acid (LPH)...
This study aims to identify suitable candidates for axillary sentinel lymph node biopsy (SLNB) or targeted dissection (TAD) among clinical N2 (cN2) triple-negative (TN) HER2 positive (HER2+）breast cancer patients following neoadjuvant therapy（NAT）.
In recent years, the RNA-binding protein quaking 5 (QKI-5) has been recognized as a novel tumor suppressor in many cancers. To date, no studies have examined role of QKI-5 prostate cancer. The present study was designed to elucidate correlation expression with clinical pathological features and prognosis an overwhelming majority 184 cases cancer samples analyzed, significantly decreased, which largely due high promoter methylation levels. Using lentiviral vectors, we established two stable...
Hepatic ischemia-reperfusion injury is an inevitable consequence during liver surgery. The outcome particularly poor in cirrhotic livers, which are more prone to hepatic injury. We aim study whether FTY720 could attenuate both normal and livers. applied a 70% liver-ischemia (60 min) model rats with or was given 20 min before ischemia 10 reperfusion (1 mg/kg, i.v.). Liver tissues blood were sampled at min, 60 90 6 h 24 after for detection of MAPK-Egr-1, Akt pathways caspase cascade....
Shockwaves elicited by transient pressure disturbances are used to treat musculoskeletal disorders. Previous research has shown that shockwave treatment affects T-cell function, enhancing proliferation and IL-2 expression activating p38 mitogen-activated protein kinase (MAPK) signaling. Here we investigated the signaling pathway which shockwaves mediate MAPK phosphorylation. We found at an intensity of 0.18 mJ/mm 2 induce release extracellular ATP from human Jurkat T-cells least in part...
Mirk/Dyrk1B contributes to G0 arrest by destabilization of cyclin D1 and stabilization p27kip1 maintain the viability quiescent human cancer cells, it could be negatively regulated mitogenic-activated protein kinase (MAPK)/extracellular signal-regulated (ERK) signaling. This study was performed investigate effect on cell cycle survival cells involving MAPK/ERK signaling.The correlations between expression active ERK1/2 detected western blot in both ovarian non-small lung (NSCLC) were...
Increasing evidence has placed eukaryotic translation initiation factor 4E (eIF4E) at the hub of tumor development and progression. Several studies have reported that eIF4E is over‐expressed in cervical cancer; however, mechanism remains elusive. The results this study further confirm over‐expression cancer tumors cell lines, we discovered transcription induced by protein E6 human papillomavirus (HPV). Moreover, regulation significantly influences proliferation, cycle, migration, apoptosis....
Stimuli-responsive nanocarriers for anticancer drug and gene co-delivery are a promising strategy in cancer therapy due to their combination of chemotherapy therapy. In this work, we developed facile effective method fabricate stimuli-responsive based on complexes polyethylenimine (PEI) with an adenosine triphosphate (ATP) responsive aptamer duplex (ARAD). No chemical reactions or complex modifications were used the construction processes. system, Doxorubicin-loaded plasmid DNA (p53) can be...
The success of small interfering RNA (siRNA)-mediated gene silencing for cancer therapy is still limited because its instability and poor intracellular internalization. Traditional cationic carriers cannot adequately meet the need clinical application siRNA. We herein report a dual-functional liposome containing cholesterol derivative metformin, i.e., LipoMET, which takes advantage fusogenic activity as well intrinsic tumor apoptosis inducing ability biguanide moiety to achieve combinational...
Current therapies for HER2-positive breast cancer have limited efficacy in patients with triple-positive (TPBC). We conduct a multi-center single-arm phase 2 trial to test the and safety of an oral neoadjuvant therapy pyrotinib, letrozole dalpiciclib (a CDK4/6 inhibitor) treatment-naïve, stage II-III TPBC Karnofsky score ≥70 (NCT04486911). The primary endpoint is proportion pathological complete response (pCR) axilla. secondary endpoints include residual burden (RCB)-0 or RCB-I, objective...
Abstract Currently lacking research to explore the correlation between inflammatory markers and efficacy of immune checkpoint inhibitors (ICIs) combined with chemotherapy in treatment advanced gastric cancer. This study is a retrospective included patients cancer who receiving ICIs from January 2020 December 2022. We analysed relationship systemic constructed clinical prediction model. A nomogram was based on results bidirectional stepwise regression total 197 were enrolled training group,...
Amomum tsao-ko is an economically important spice plant in the ginger family (Zingiberaceae). The dried ripe fruit has been widely used as and medicine Southeast Asia due to its distinct flavor metabolites. However, there little genomic information available understand biosynthesis of characteristic compounds. Here, we present a high-quality chromosome-level genome A. with total length 2.08 Gb assembled into 24 chromosomes. Potential relationships between genetic variation chemical...