A5011644190- Nanoplatforms for cancer theranostics
- RNA Interference and Gene Delivery
- Immunotherapy and Immune Responses
- Nanoparticle-Based Drug Delivery
- Immune cells in cancer
- Electrospun Nanofibers in Biomedical Applications
- Bone Tissue Engineering Materials
- Advanced biosensing and bioanalysis techniques
- Extracellular vesicles in disease
- Mesenchymal stem cell research
- Ocular Oncology and Treatments
- Silk-based biomaterials and applications
- Immune Cell Function and Interaction
- Wound Healing and Treatments
- Ferroptosis and cancer prognosis
- CAR-T cell therapy research
- Tissue Engineering and Regenerative Medicine
- Cancer Immunotherapy and Biomarkers
- Radiation Therapy and Dosimetry
- Graphene and Nanomaterials Applications
- Advanced Sensor and Energy Harvesting Materials
- Natural Language Processing Techniques
- Hydrogels: synthesis, properties, applications
- Retinal Development and Disorders
- Periodontal Regeneration and Treatments
Central South University
2014-2025
Ningbo Institute of Industrial Technology
2023-2024
Chinese Academy of Sciences
2017-2024
York University
2024
University of Chinese Academy of Sciences
2020-2024
Wenzhou Medical University
2017-2024
First Affiliated Hospital of Wenzhou Medical University
2021-2024
University of South China
2023-2024
Taiyuan Heavy Industry (China)
2024
State Key Laboratory of Vehicle NVH and Safety Technology
2024
One of the major challenges in applying nanomedicines to cancer therapy is their low interstitial diffusion solid tumors. Although modification nanocarrier surfaces with enzymes that degrade extracellular matrix a promising strategy improve tumors, it remains challenging apply this vivo via systemic administration nanocarriers due biological barriers, such as reduced blood circulation time enzyme-modified nanocarriers, loss enzyme function vivo, and life-threatening side effects. Here, we...
Research into long-circulating nanoparticles has in the past focused on reducing their clearance by macrophages. By engineering a hierarchical polyethylene glycol (PEG) structure nanoparticle surfaces, we revealed an alternative mechanism to enhance blood circulation. The conjugation of second PEG layer at density close but lower than mushroom-to-brush transition regime conventional PEGylated dramatically prolongs circulation via reduced uptake non-Kupffer cells liver, especially liver...
Patients with bone defects suffer from a high rate of disability and deformity. Poor contact grafts defective bones insufficient osteogenic activities lead to increased loose risks unsatisfied repair efficacy. Although self-expanding scaffolds were developed enhance integration, the limitations on transition temperature bioactivity hindered greatly their clinical application. Herein, we report near-infrared-responsive tight-contacting scaffold that comprises shape memory polyurethane (SMPU)...
Diabetic retinopathy (DR) and other diabetic vascular complications are the leading cause of death disability in patients with suboptimum glycemic control. In pathogenesis diseases, hyperglycemia-induced oxidative stress, DNA damage, poly-ADP-ribose-polymerase (PARP) hyperactivation play important roles endothelial cell impairment. Adipose differentiation-related protein FBXW7 was reported to regulate PGC-1α stability mitochondrial homeostasis. Here, we investigated role mechanism repairing...
Abstract Background Rheumatoid arthritis (RA) is a prevalent inflammatory autoimmune disease characterised by persistent inflammation and joint damage with elevated levels of reactive oxygen species (ROS). Current treatment modalities for RA have significant limitations, including poor bioavailability, severe side effects, inadequate targeting inflamed joints. Herein, we synthesised cerium/manganese oxide nanoparticles (NPs) as efficient drug carriers antioxidant catalytic-like functions...
Abstract Smart hydrogels responsive to external stimuli are promising for various applications such as soft robotics and smart devices. High mechanical strength fast response rate particularly important the construction of hydrogel actuators. Herein, tough with rapid rates synthesized using vinyl‐functionalized poly( N ‐isopropylacrylamide) (PNIPAM) microgels macro‐crosslinkers ‐isopropylacrylamide monomers. The compression obtained PNIPAM is up 7.13 MPa. microgel‐crosslinked significantly...
Human choroidal melanoma (HCM) is one of the most common primary intraocular tumors and easily provokes liver metastases owing to lack sensitive noninvasive therapeutic methods. Concerning imaging diagnostics predicaments for melanoma, we designed microenvironment-triggered degradable hydrogels (RENP-ICG@PNIPAM:Dox-FA) based on ultrasmall (<5 nm) rare-earth nanoparticles (RENPs) with enhanced NIR-II luminescence. The diameter can significantly enhance luminescence performance RENPs. RENPs...
Here, the aim was to evaluate protective effect of Lactobacillus plantarum-derived postbiotics, i.e., LP-cs, on acute alcoholic liver injury (ALI). After preincubation with HL7702 human hepatocytes were treated alcohol, and then cell survival rate measured. C57BL/6 male mice presupplemented or without LP-cs LP-cs-loaded calcium alginate hydrogel (LP-cs-Gel) for 3 weeks given 50% alcohol gavage establish mouse model ALI, presupplementation, LP-cs-Gel presupplementation. The histomorphology...
Abstract The utilization of extracellular vesicles (EV) in immunotherapy, aiming at suppressing peripheral immune cells responsible for inflammation, has demonstrated significant efficacy treating various inflammatory diseases. However, the clinical application EV faced challenges due to their inadequate targeting ability. In addition, most circulating would be cleared by liver, resulting a short biological half-life after systemic administration. Inspired natural microvesicles (MV, as...
Abstract The development of auxetic materials, known for their unique negative Poisson’s ratio, is transforming various industries by introducing new mechanical properties and functionalities. These materials offer groundbreaking applications improved performance in engineering other areas. Initially found natural behaviors have been developed synthetic materials. Auxetic boast properties, including synclastic behavior, variable permeability, indentation resistance, enhanced fracture...
To improve the transfection efficiency of chitosan as a nonviral gene delivery vector, dendronized derivative was prepared by copper-catalyzed azide alkyne cyclization reaction propargyl focal point poly(amidoamine) dendron with 6-azido-6-deoxy-chitosan. Its structure characterized (1)H NMR and FTIR analyses its buffering capacity evaluated acid-base titration. In particular, complexation plasmid DNA investigated agarose gel electrophoresis, zeta potential, particle size well transmission...
Background: Excessive expression of matrix metalloproteinase-9 (MMP-9) is deleterious to the cutaneous wound-healing process in context diabetes. The aim present study was explore whether a cationic star-shaped polymer consisting ß-cyclodextrin (ß-CD) core and poly(amidoamine) dendron arms (ß-CD-[D 3 ] 7 ) could be used as gene carrier small interfering RNA (siRNA) reduce MMP-9 for enhanced diabetic wound healing. Methods: cytotoxicity ß-CD-(D investigated by...
Superhydrophobic and oleophilic sponges have been demonstrated as promising candidates for oil/water separation. However, there are still challenges in large-scale fabrication of superhydrophobic with low cost feasible method industrial applications. Herein, we report a melamine sponge functionalized by uniform polydimethylsiloxane (PDMS) film that can be easily coated onto the skeleton through UV-assisted thiol-ene click reactions. The PDMS films characterized hierarchically striped...
An unmet need in nanomedicine is to prepare biocompatible and renal clearable nanoparticles by controlling the diameter, composition surface properties of nanoparticles.