A5064664893- Nanoplatforms for cancer theranostics
- Phytochemistry and Bioactive Compounds
- Extracellular vesicles in disease
- Nanoparticle-Based Drug Delivery
- Immunotherapy and Immune Responses
- Autophagy in Disease and Therapy
- Advanced biosensing and bioanalysis techniques
- Genetic factors in colorectal cancer
- Ferroptosis and cancer prognosis
- Remote Sensing and Land Use
- Advanced Nanomaterials in Catalysis
- RNA Interference and Gene Delivery
- Liver physiology and pathology
- Cancer Mechanisms and Therapy
- Cancer Immunotherapy and Biomarkers
- Pharmacological Effects of Natural Compounds
- Cancer-related molecular mechanisms research
- Corneal Surgery and Treatments
- Immune Cell Function and Interaction
- Immune cells in cancer
- RNA modifications and cancer
- Microbial Fuel Cells and Bioremediation
- Nanocluster Synthesis and Applications
- Chronic Myeloid Leukemia Treatments
- Nuclear Structure and Function
China Pharmaceutical University
2024-2025
Nanjing University
2024-2025
Fourth Affiliated Hospital of China Medical University
2025
China Medical University
2025
Hangzhou Medical College
2017-2024
Zhejiang Provincial People's Hospital
2016-2024
First Affiliated Hospital of Zhengzhou University
2024
Beijing Jiaotong University
2024
Blood Center of Zhejiang Province
2023
Tianjin University of Science and Technology
2022
Abstract Background Rheumatoid arthritis (RA) is a prevalent inflammatory autoimmune disease characterised by persistent inflammation and joint damage with elevated levels of reactive oxygen species (ROS). Current treatment modalities for RA have significant limitations, including poor bioavailability, severe side effects, inadequate targeting inflamed joints. Herein, we synthesised cerium/manganese oxide nanoparticles (NPs) as efficient drug carriers antioxidant catalytic-like functions...
Cell membrane-camouflaged nanoparticles (NPs) are drawing increasing attention because their surfaces acquire some characteristics of the cell membranes, making them a unique class biomimetic materials for diverse applications. Modification membrane or combination different types membranes can enhance functionality.We prepared platelet and tumor camouflaged β-mangostin-loaded NPs, which were synthesized with platelet-C6 hybrid coating, poly(lactic-co-glycolic acid), β-mangostin (β-PCNPs)....
Although enormous success has been obtained for dendritic cells (DCs)-mediated antigen-specific T anticancer immunotherapy in the clinic, it still faces major challenging problems: insufficient DCs tumor tissue and low response rate lacking antigen expression, especially immunogenic tumors such as pancreatic cancer. Here, these challenges are tackled through microenvironment responsive nanogels with prominent tumor-targeting capability by Panc02 cell membranes coating inhibition of...
Redox/pH dual-responsive nanogels have shown great advantages in enhancing tumor chemotherapy.
Abstract Glioma treatment remains a challenge owing to unsatisfactory targeted chemotherapy, where the blood–brain barrier (BBB) hinders efficient uptake of therapeutics into brain. Vasculogenic mimicry (VM) formed by invasive glioma cells negatively affects glioma. Herein, we developed biomimetic drug delivery system comprising doxorubicin-loaded platelet membrane-coated nanogel (DOX@PNGs). The nanogels provide great redox/pH dual responsiveness, while membrane (PLTM) promotes stability and...
Marsdenia tenacissimae extraction (MTE) as a traditional Chinese herb has long been used to treat some diseases such tumors in China. However, the potential effectiveness of MTE leukemia not yet fully understood, and related molecular mechanism is still unknown. In present study, we aimed evaluate effects on proliferation apoptosis Jurkat cells (T-ALL lines) lymphocytes from T-ALL (T-cell acute lymphoblastic leukemia) patients. Firstly, CCK8 assays flow cytometry revealed that...
Glioma is the most common malignant tumor of nervous system, which accounts for more than 45% central system tumors and seriously threatens our health. Because high mortality rate, limitations, many complications traditional treatment methods, new methods are urgently needed. β-Mangostin a natural compound derived from fruit Garcinia mangostana L. it has anticancer activity in several types cancer cells. However, antitumor effect β-mangostin glioma not been clarified. Hence, this study aimed...
Marsdenia tenacissimae extraction (MTE), a traditional herbal medicine, has exhibited anti-tumor effects on variety of cancers. However, its effectiveness and the mechanism action in Hepatocellular carcinoma (HCC) not been fully understood. In present study, we demonstrate that C21 steroid-enriched fraction from MTE, which contains five main steroids (FR5) exhibits obvious pharmacological activities HCC cells vitro vivo. FR5 induces apoptosis inhibits proliferation migration HepG2 Bel7402...
Abstract Background Infertility affects approximately 10–15% of reproductive-age men worldwide, and genetic causes play a role in one-third cases. As Bin-Amphiphysin-Rvs (BAR) domain protein, protein interacting with C-kinase 1 (PICK1) deficiency could lead to impairment acrosome maturation. However, its effects on auxiliary germ cells such as Sertoli are unknown. Purpose The present work was aimed use multi-omics analysis research the PICK1 identify effective biomarkers distinguish fertile...
Abstract Hepatocellular carcinoma (HCC) mainly depends on liver fibrosis/cirrhosis, which is regulated by tumor cells and the microenvironment (TME), a crucial factor in progression. This study aimed to identify abnormally expressed miR‐500a‐3p hepatitis‐cirrhosis‐HCC pathway explored roles of HCC A clinical cohort patients with studied retrospectively. Subsequently, role transported exosomes hepatic stellate cell (HSC) activation, hepatoma growth invasion, immune differentiation determined...
The function played by cartilage intermediate layer protein 2 (CILP2) between colorectal cancer (CRC) progression and immune response remains unclear, especially with respect to cell infiltration checkpoints. Materials Methods: We examined CILP2 expression in Cancer Genome Atlas (TCGA) COAD-READ cohort analyzed its relationship clinicopathological features, mutations, survival, immunity. Gene ontology, Kyoto Encyclopedia of Genes Genomes pathway analysis, gene set enrichment analyses (GSEA)...
Stimulus-responsive nanocarrier systems are promising in cancer treatment. They improve drug stability and facilitate controlled release. However, single-responsive nanocarriers still face insufficient tumor targeting low efficacy.In this study, we synthesized folate-modified DSPE-PEOz nanomicelles with PEG chains loaded them magnetic iron particles doxorubicin (DOX). Folic acid (FA) was employed as a ligand to target cells actively. The biocompatible acid-sensitive carriers. Magnetic...
ObjectiveIn this study, we aimed to determine whether proly4-hydroxylase-III (P4HA3) could be used as a biomarker for the diagnosis of colorectal cancer (CRC) well determining prognosis.MethodsWe The Cancer Genome Atlas (TCGA) database analyze P4HA3 expression in CRC and further investigated association between clinicopathological parameters, immune infiltration, prognosis patients with CRC. Enrichment analysis was conducted investigate potential biological role To verify results TCGA...
Glioma, a common and highly malignant central nervous system tumor, markedly influences patient prognosis via interactions with glioma-associated macrophages. Previous research has revealed the anticancer potential of β-mangostin, xanthone derivative obtained from mangosteen fruit. This investigated role β-mangostin on microglia in glioma microenvironment evaluated efficacy combined anti-PD-1 antibody (αPD-1) glioma-bearing mice. The results showed that, attenuated M2 polarization BV2 cells...