A5102897815- Autophagy in Disease and Therapy
- Retinal Diseases and Treatments
- Ocular Oncology and Treatments
- Retinal and Macular Surgery
- Natural product bioactivities and synthesis
- Retinal Development and Disorders
- Neuroscience and Neural Engineering
- Cancer-related Molecular Pathways
- Metabolomics and Mass Spectrometry Studies
- Sirtuins and Resveratrol in Medicine
- Ginseng Biological Effects and Applications
- Ferroptosis and cancer prognosis
- Genomics, phytochemicals, and oxidative stress
- Glaucoma and retinal disorders
- Metabolism, Diabetes, and Cancer
- Light effects on plants
- Ocular Diseases and Behçet’s Syndrome
- Phytochemical compounds biological activities
- Ocular Infections and Treatments
- Plant Gene Expression Analysis
- Histone Deacetylase Inhibitors Research
- Photosynthetic Processes and Mechanisms
- Single-cell and spatial transcriptomics
- Phagocytosis and Immune Regulation
- Peptidase Inhibition and Analysis
Zhejiang University
2016-2025
Women's Hospital, School of Medicine, Zhejiang University
2025
Zhejiang Lab
2023-2024
University of Chinese Academy of Sciences
2021-2023
Zhejiang Cancer Hospital
2021-2023
Massachusetts Eye and Ear Infirmary
2019-2023
Smith-Kettlewell Eye Research Institute
2019-2023
Harvard University
2019-2023
Chinese Academy of Sciences
2022-2023
Cancer Hospital of Chinese Academy of Medical Sciences
2021-2022
Chalocomoracin (CMR), one of the major secondary metabolites found in fungus-infected mulberry leaves, is a potent anticancer agent. However, its mechanism remains elusive. Here, we demonstrated anti-tumor activity and molecular CMR both vitro vivo. We showed for first time that treatment markedly promoted paraptosis along with extensive cytoplasmic vacuolation derived from endoplasmic reticulum, rather than apoptosis, PC-3 MDA-MB-231cell lines. Additional studies revealed ectopic expression...
The leaves of Morus alba L is a traditional Chinese medicine widely applied in lung diseases. Moracin N (MAN), secondary metabolite extracted form the L, potent anticancer agent. But its molecular mechanism remains unveiled.In this study, we aimed to examine effect MAN on human cancer and reveal underlying mechanism.MTT assay was conducted measure cell viability. Annexin V-FITC/PI staining used detect apoptosis. Confocal microscope performed determine formation autophagosomes autolysosomes....
Bradyarrhythmia is a major cause of cardiovascular disease morbidity and mortality. Currently, medication and/or surgery are the conventional clinical therapeutic strategies for bradyarrhythmia, whereas drug side effects, invasive surgery, or potential complications limit their extensive application. Therefore, development alternative therapies bradyarrhythmia urgently needed. Herein, we propose universal efficient drug-mimicking strategy to treat which relies on photothermal properties...
Diabetic retinopathy is the most common microvascular complication of diabetes, and in advanced diabetic appear vitreal fibrovascular membranes that consist a variety cells, including vascular endothelial cells (ECs). New therapeutic approaches for this are urgently needed. Here, we report cultured human retinal ECs, high glucose induced expression p110δ, which was also expressed ECs from patients with diabetes. This catalytic subunit receptor-regulated PI3K isoform δ known to be highly...
Abstract Capilliposide B (CPS‐B), a novel oleanane triterpenoid saponin derived from Lysimachia capillipes Hemsl, is potent anticancer agent. However, its mechanism remains elusive. In the present study, we demonstrated anti‐tumor activity and molecular of CPS‐B both in vitro vivo. Proteomic analysis using isobaric tags for relative absolute quantitation techniques suggested that modulated autophagy prostate cancer (PC). Moreover, Western blotting showed epithelial–mesenchymal transition...
Abstract Objectives The therapeutic effect against triple-negative breast cancer (TNBC) varies among individuals. Finding signatures to predict immune efficacy is particularly urgent. Considering the connection between microenvironment and hypoxia, hypoxia-related could be more effective. Therefore, in this study, we aimed sought construct a hypoxia-immune-related prediction model for identify targets. Methods Immune hypoxia status TNBC were investigated using single-sample Gene Set...
Bradyarrhythmia poses a serious threat to human health, with chronic progression causing heart failure and acute onset leading sudden death. In this study, we develop scalable drug-mimicking nanoplasmonic therapeutic strategy by introducing gold nanorod (Au NR) mediated near-infrared (NIR) photothermal effects. An integrated sensing regulation platform is established for in situ synchronized NIR laser electrophysiological property recording. The Au NR plasmonic enables the restoration of...
Phosphoinositide 3-kinases (PI3Ks) are a family of lipid kinases that play critical role in transmitting signals from cell-surface molecules to intracellular protein effectors. Key PI3Ks include PI3Kα, PI3Kβ, and PI3Kδ, which regulated by receptors. The signaling pathway comprising the PI3Ks, along with Ser/Thr kinase (AKT), proto-oncogene product (mouse double minute (MDM)2), tumor suppressor (p53), plays an essential experimental proliferative vitreoretinopathy (PVR), is fibrotic blinding...
Mahonia bealei (M. bealei) is a traditional Chinese medicine containing high alkaloid content used to treat various diseases. Generally, only dried root and stem are as medicines, considering that the in M. leaves lower than stems roots. Some previous research found flavonoid contents may increase when exposed ultraviolet B (UV-B) radiation. However, underlying mechanism of action still unclear. In this study, we titanium dioxide material enrichment mass-based label-free quantitative...
Thyroid dysfunction, including hypothyroidism (THO) and hyperthyroidism (THE), commonly arise from pathological processes in the thyroid gland. The current diagnosis of dysfunction varies because age sex patients. aim this study was to explore novel candidate biomarker panels for screening with mass spectrometry bioinformatics.Plasma samples were collected 15 THE patients, 9 THO healthy controls. Data Independent Acquisition(DIA)-based proteomic untargeted metabolomic analyses performed...
Abnormal angiogenesis is associated with intraocular diseases such as proliferative diabetic retinopathy and neovascular age-related macular degeneration, current therapies for these eye are not satisfactory. The purpose of this study was to determine whether capilliposide B (CPS-B), a novel oleanane triterpenoid saponin derived from Lysimachia capillipes Hemsl, can inhibit vascular endothelial growth factor (VEGF)-induced signaling events cellular responses in primary human retinal...
Quercetin‑3‑O‑α‑L‑rhamnopyranoside (QI) is derived from the leaves of Lindera aggregata (Sims) Kosterm. And exhibits multiple biological activities, including an antioxidant activity. However, detailed molecular mechanism its activity remains unknown. The aim present study was to investigate QI and underlying in human umbilical vein endothelial cells (HUVECs). An oxidative stress model established HUVECs using H2O2, were then treated with different concentrations QI. results revealed that...
Abstract Developing accurate electrophysiological recording platforms is crucial for investigating cellular electrical activities, understanding the mechanisms underlying cardiovascular disease, and advancing therapeutic strategies. While successful of intracellular status has been achieved by 3D micro/nano devices, their preparation through demanding micro/nanofabrication poorly controllable solvothermal synthesis an impediment to widespread utilization. Easier‐to‐access electrodes are...