A5101864472- Retinal Diseases and Treatments
- Machine Learning and Data Classification
- Glaucoma and retinal disorders
- Retinal Development and Disorders
- Domain Adaptation and Few-Shot Learning
- Tea Polyphenols and Effects
- Anomaly Detection Techniques and Applications
- Music and Audio Processing
- Heme Oxygenase-1 and Carbon Monoxide
- Machine Learning and Algorithms
- Inflammasome and immune disorders
- Plant-Microbe Interactions and Immunity
- Connexins and lens biology
- Human Pose and Action Recognition
- Corneal surgery and disorders
- Proteoglycans and glycosaminoglycans research
- Peroxisome Proliferator-Activated Receptors
- Neuroinflammation and Neurodegeneration Mechanisms
- Mitochondrial Function and Pathology
- Mycotoxins in Agriculture and Food
- Plant Pathogens and Fungal Diseases
- Neuroscience and Neuropharmacology Research
- Mesenchymal stem cell research
- Adversarial Robustness in Machine Learning
- Water Systems and Optimization
Xiangya Hospital Central South University
2016-2025
Central South University
2016-2025
Hunan University
2020-2025
Anhui Agricultural University
2019-2024
Nanjing Agricultural University
2022-2024
The University of Sydney
2019-2023
National Clinical Research Center for Digestive Diseases
2022
Ministry of Agriculture and Rural Affairs
2022
Jiangsu Academy of Agricultural Sciences
2022
First Affiliated Hospital of Zhengzhou University
2014
Deep networks have strong capacities of embedding data into latent representations and finishing following tasks. However, the largely come from high-quality annotated labels, which are expensive to collect. Noisy labels more affordable, but result in corrupted representations, leading poor generalization performance. To learn robust handle noisy we propose selective-supervised contrastive learning (Sel-CL) this paper. Specifically, Sel-CL extend supervised (Sup-CL), is powerful...
Abstract Glaucoma can result in retinal ganglion cell (RGC) death and permanently damaged vision. Pathologically high intraocular pressure (ph-IOP) is the leading cause of vision during glaucoma; however, controlling ph-IOP alone does not entirely prevent loss glaucomatous RGCs, underlying mechanism remains elusive. In this study, we reported an increase ferric iron patients with acute primary angle-closure glaucoma (the most typical damage) compared average population by analyzing free...
In label-noise learning, \textit{noise transition matrix}, denoting the probabilities that clean labels flip into noisy labels, plays a central role in building \textit{statistically consistent classifiers}. Existing theories have shown matrix can be learned by exploiting \textit{anchor points} (i.e., data points belong to specific class almost surely). However, when there are no anchor points, will poorly learned, and those current classifiers significantly degenerate. this paper, without...
Learning with the \textit{instance-dependent} label noise is challenging, because it hard to model such real-world noise. Note that there are psychological and physiological evidences showing we humans perceive instances by decomposing them into parts. Annotators therefore more likely annotate based on parts rather than whole instances, where a wrong mapping from classes may cause instance-dependent Motivated this human cognition, in paper, approximate exploiting \textit{part-dependent}...
Human motion prediction is a classical problem in computer vision and graphics, which has wide range of practical applications. Previous effects achieve great empirical performance based on an encoding-decoding style. The methods this style work by first encoding previous motions to latent representations then decoding the into predicted motions. However, practice, they are still unsatisfactory due several issues, including complicated loss constraints, cumbersome training processes, scarce...
Abstract Fatty acid binding proteins (FABPs) are a class of small molecular mass intracellular lipid chaperone that bind to hydrophobic ligands, such as long‐chain fatty acids. FABP5 expression was significantly upregulated in the N ‐methyl‐ d ‐aspartic (NMDA) model, microbead‐induced chronic glaucoma and DBA/2J mice. Previous studies have demonstrated can mediate mitochondrial dysfunction oxidative stress ischemic neurons, but role cell death retina NMDA injury models is unclear. In this...
Pericyte degeneration is an early event in diabetic retinopathy and plays important role progression of retinopathy. Clinical studies have shown that fenofibrate, a peroxisome proliferator-activated receptor α (PPARα) agonist, has robust therapeutic effects on type 2 patients. We evaluated the protective effect PPARα against pericyte loss In streptozotocin-induced mice, fenofibrate treatment significantly ameliorated retinal acellular capillary formation loss. contrast, PPARα(-/-) mice with...
Abstract Radiation-induced optic neuropathy (RION) is a devastating complication following external beam radiation therapy (EBRT) that leads to acute vision loss. To date, no efficient, available treatment for this complication, due partly the lack of understanding regarding developmental processes behind RION. Here, we report caused changes in mitochondrial dynamics by regulating fission proteins dynamin-related protein 1 (Drp1) and fission-1 (Fis1). Concurrent with an excessive production...
In learning with noisy labels, the sample selection approach is very popular, which regards small-loss data as correctly labeled during training. However, losses are generated on-the-fly based on model being trained and thus large-loss likely but not certainly to be incorrect. There actually two possibilities of a point: (a) it mislabeled, then its loss decreases slower than other data, since deep neural networks "learn patterns first"; (b) belongs an underrepresented group has been selected...
Glaucoma is a leading cause of irreversible blindness. In this study, we investigated if transplanted stem cells are able to rescue glaucoma mouse model with transgenic myocilin Y437H mutation and explored the possible mechanisms. Human trabecular meshwork (TMSCs) were intracamerally which reduced intraocular pressure, increased outflow facility, protected retinal ganglion preserved their function. TMSC transplantation also significantly TM cellularity, promoted secretion from into aqueous...
Glaucoma is the leading cause of irreversible blindness worldwide. Emerged evidence has shown that glaucoma considered an immune system related disorder. The gut largest organ in human body and microbiota (GM) plays role maintaining homeostasis. But, how GM influences remains unrevealed. This study aimed at investigating key molecules/pathways mediating to provide new biomarkers for future predictive, preventive, personalized medicine.Datasets from primary open-angle (POAG) patients...
Abstract Glaucoma is the leading cause of irreversible vision loss, and reducing elevated intraocular pressure currently only effective clinical treatment. The trabecular meshwork main resistance site for aqueous outflow that maintains pressure. In this study, we transplanted human stem cells (TMSCs) intracamerally into mice received laser photocoagulation over a 180° arc meshwork. TMSCs preferentially homed integrated to laser-damaged region expressed differentiated cell markers at 2 4...
The trabecular meshwork (TM) is an ocular tissue that maintains intraocular pressure (IOP) within a physiologic range. Glaucoma patients have reduced TM cellularity and, frequently, elevated IOP. To establish stem cell-based approach to restoring function and normalizing IOP, human adipose-derived cells (ADSCs) were induced differentiate in vitro. These ADSC-TM displayed cell-like genotypic profile, became phagocytic, responded dexamethasone stimulation, characteristic of cells. After...
Fusarium head blight (FHB) is primarily caused by graminearum and severely reduces wheat yield, causing mycotoxin contamination in grains derived products. F. graminearum-secreted chemical toxins stably accumulate plant cells, disturbing host metabolic homeostasis. We determined the potential mechanisms underlying FHB resistance susceptibility wheat. Three representative varieties (Sumai 3, Yangmai 158, Annong 8455) were inoculated with their metabolite changes assessed compared. In total,...