A5029365676- Liver Disease Diagnosis and Treatment
- Immune Response and Inflammation
- Liver Disease and Transplantation
- Immunotherapy and Immune Responses
- Drug-Induced Hepatotoxicity and Protection
- Immune Cell Function and Interaction
- Liver Diseases and Immunity
- Pediatric Hepatobiliary Diseases and Treatments
- Pharmacological Effects of Natural Compounds
- Liver physiology and pathology
- Hepatitis B Virus Studies
- Antibiotic Resistance in Bacteria
- Extracellular vesicles in disease
- RNA Interference and Gene Delivery
- COVID-19 epidemiological studies
- Sepsis Diagnosis and Treatment
- Pancreatitis Pathology and Treatment
- Viral gastroenteritis research and epidemiology
- Salmonella and Campylobacter epidemiology
- SARS-CoV-2 and COVID-19 Research
- Cytokine Signaling Pathways and Interactions
- Pancreatic and Hepatic Oncology Research
- Inflammasome and immune disorders
- Advanced Glycation End Products research
- Travel-related health issues
First Affiliated Hospital of Wenzhou Medical University
2016-2025
Wenzhou Medical University
2016-2025
China Animal Health and Epidemiology Center
2025
University of Chinese Academy of Sciences
2023-2024
State Key Laboratory For Conservation and Utilization of Subtropical Agro-Bioresources
2024
Guangxi University
2024
Shandong Provincial Institute of Dermatology and Venereology
2023
Third Affiliated Hospital of Sun Yat-sen University
2013
Sun Yat-sen University
2013
Background No data is available about in-flight transmission of SARS-CoV-2. Here, we report an cluster COVID-19 and describe the clinical characteristics these patients.
Abstract The utilization of extracellular vesicles (EV) in immunotherapy, aiming at suppressing peripheral immune cells responsible for inflammation, has demonstrated significant efficacy treating various inflammatory diseases. However, the clinical application EV faced challenges due to their inadequate targeting ability. In addition, most circulating would be cleared by liver, resulting a short biological half-life after systemic administration. Inspired natural microvesicles (MV, as...
Elevated serum ferritin levels (SFLs) was previously reported to be related with hepatic histologic severity and advanced liver fibrosis among non-alcoholic fatty disease (NAFLD) patients. However, whether NAFLD influences SFLs remains uncertain needs more clinical evidences. This study explored the differences of in US adults or without NAFLD.We conducted a cross-sectional 3689 participants aged 18-80 years using National Health Nutrition Examination Survey (NHANES) 2017-2018 cycle. status...
Multidrug-resistant Staphylococcus aureus ( S. ) poses an increasingly serious threat to agricultural safety and public health. Based on the concept of “One Health,” this study analyzed multidrug resistance transmission factors isolated from “animal–environment–human” interface during one feeding cycle commercial broilers in China by using antimicrobial susceptibility testing whole genome sequencing (WGS) technologies. The results showed that stage 1, isolation rate was 1.32% (6/453),...
Introduction In recent years, the epidemic trend and antimicrobial resistance of Salmonella from swines broilers, especially extended-spectrum β-lactamase (ESBLs)-producing , pose a serious threat to human animal health. Methods this study, we employed serotype identification, drug sensitivity testing, detection ESBL-producing strains, whole genome sequencing analyze epidemiological trends isolates as well genetic evolutionary relationships strains in China 2014 2023. Results The results...
Dysfunction of peripheral blood neutrophils occurs in acute-on-chronic liver failure (ACLF). However, the molecular mechanisms involved pathophysiology ACLF remains poorly understood. Data downloaded from GEO database (GSE142255) was used to identify both and neutrophil-related genes with help limma package Weighted Gene Co-Expression Network Analysis (WGCNA) algorithms. The analysis identified 288 ACLF-related differentially expressed (DEGs) circulating cells. Among these, three were found...
Background and aims Traditional observational studies have yielded inconsistent findings regarding the association between COVID-19 HBV/HIV infections, as well protective effects of antiviral therapy against severe COVID-19. This study aimed to investigate potential links current use rates acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection symptoms in patients with SARS-CoV-2 HBV/HIV. Methods Using a questionnaire-based survey, we recorded whether participants had been infected...
Kinesin family member 20A (KIF20A) is an essential regulator of cytokinesis. In this study, by performing a retrospective study based on data from the Cancer Genome Atlas (TCGA)-Liver and Hepatocellular Carcinoma (LIHC) cohort, we tried to assess independent prognostic value KIF20A in terms overall survival (OS) recurrence-free (RFS). Results showed that normal liver tissues had very low expression compared with other cohorts TCGA. However, primary HCC (N = 371) significantly elevated than...
To explore the therapeutic effects and mechanisms of interleukin 10 gene-modified bone marrow-derived dendritic cells (DC-IL10) on liver fibrosis.In vitro, BMDCs were transfected with lentiviral-interleukin 10-GFP (LV-IL10-GFP) at MOI 1 : 40. Then, phenotype (MHCII, CD80, CD86) allo-stimulatory ability DC-IL10 identified by flow cytometry, levels IL-10 IL-12 (p70) secreted into culture supernatants quantified ELISA. In vivo, was injected mice CCl4-induced fibrosis through tail vein....
Primary biliary cholangitis (PBC) is a classical autoimmune disease, which highly influenced by genetic determinants. Many genome-wide association studies (GWAS) have reported that numerous loci were significantly associated with PBC susceptibility. However, the effects of determinants on liver cells and its immune microenvironment for remain unclear.We constructed powerful computational framework to integrate GWAS summary statistics scRNA-seq data uncover genetics-modulated cell...
Aims . Acute-on-chronic liver failure (ACLF) and acute (ALF) are similar in many respects during their exacerbation; however, ACLF generally has a poorer prognosis. We aimed to investigate the role dynamic changes of regulatory T cell (Treg) helper 17 (Th17) proportions progress. Methods All rats were classified into two groups randomly: group ALF (control group). The rat model was preestablished by intraperitoneal injection carbon tetrachloride for 2 months. Then injury induced combined...
Abstract Background The prevalence of non‐alcoholic fatty liver disease (NAFLD) and obesity is worldwide on the rise. Body roundness index (BRI), as a newly developed anthropometric indicator, has been recently reported to identify obesity. However, it still unclear whether BRI associated with NAFLD. Methods Data were from National Health Nutrition Examination Survey (NHANES) 2017–2018. NAFLD was diagnosed based hepatic steatosis defined by CAP values ≥274 dB/m. Multivariable logistic...
The class-3 semaphorins (Sema3A-F, Sema3s) are initially identified to play an important role in axonal guidance and cell migration.Our previous studies showed that Sema3s also involved the lymph node metastasis of prostate cancer, likely modulate behavior cancer with a pro-tumoral or anti-tumoral effect, depending on their subtypes.However, no study has critically investigated value expression preoperative biopsy samples for prediction biochemical recurrence (BCR) after radical...
It has been reported that hypereosinophilic syndrome may be induced by antituberculosis drugs. We herein report the case of a 43-year-old man who had on drugs for two months to treat tuberculous meningitis. During therapy, he suffered from drug rash with eosinophilia and systemic symptoms (DRESS) presenting as acute eosinophilic myocarditis, confirmed histopathologic examination. According patient's medication history, clinical features accessory examination findings, myocarditis was thought...
Despite the safety profile of subunit vaccines, inferior immunogenicity hinders their application in nasal cavity. This study introduces a novel antigen delivery and adjuvant system utilizing mucoadhesive chitosan-catechol (Chic) on silica spiky nanoparticles (Ssp) to enhance immunity through multiple mechanisms. The Chic functionalizes Ssp surface incorporates with SARS-CoV-2 spike protein receptor-binding domain (RBD) toll-like receptor (TLR)9 agonist unmethylated cytosine-guanine (CpG)...