A5001877111- Chronic Obstructive Pulmonary Disease (COPD) Research
- Air Quality and Health Impacts
- Peptidase Inhibition and Analysis
- Ubiquitin and proteasome pathways
- Ferroptosis and cancer prognosis
- Climate Change and Health Impacts
- Inflammasome and immune disorders
- Phosphodiesterase function and regulation
- Telomeres, Telomerase, and Senescence
- Immune Cell Function and Interaction
- Immune Response and Inflammation
- Intestinal and Peritoneal Adhesions
- Gastroesophageal reflux and treatments
- Immune cells in cancer
- Protein Kinase Regulation and GTPase Signaling
- Protease and Inhibitor Mechanisms
- Genomic variations and chromosomal abnormalities
- Clinical Nutrition and Gastroenterology
- Cell death mechanisms and regulation
- Cancer Immunotherapy and Biomarkers
- Nutrition and Health in Aging
- Metabolism and Genetic Disorders
- Cancer, Hypoxia, and Metabolism
- Genetic and Kidney Cyst Diseases
- Histone Deacetylase Inhibitors Research
Wenzhou Medical University
2016-2025
First Affiliated Hospital of Wenzhou Medical University
2016-2025
Nanjing Drum Tower Hospital
2024
China Pharmaceutical University
2024
Peking Union Medical College Hospital
2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2022
Kinesin family member 20A (KIF20A) is an essential regulator of cytokinesis. In this study, by performing a retrospective study based on data from the Cancer Genome Atlas (TCGA)-Liver and Hepatocellular Carcinoma (LIHC) cohort, we tried to assess independent prognostic value KIF20A in terms overall survival (OS) recurrence-free (RFS). Results showed that normal liver tissues had very low expression compared with other cohorts TCGA. However, primary HCC (N = 371) significantly elevated than...
Familial cold autoinflammatory syndrome (FCAS) is an extremely rare autosomal dominant inherited disease. Although there are four genes that have been linked with FCAS, its molecular diagnosis has challenging in a relatively large proportion of cases. In this study, we aimed to investigate the genetic defect recruited FCAS family using exome sequencing followed by in-depth bioinformatics analysis. As result, novel heterozygous stop-gain mutation (Trp408X) NLRP12 was identified clinical...
Abstract Carboxypeptidase A4 (CPA4) is a member of the metallocarboxypeptidase family. A previous study indicated that CPA4 may participate in modulation peptide hormone activity and hormone‐regulated tissue growth differentiation. However, role lung tumorigenesis remains unclear. Our revealed expression was higher both cancer cells tumor tissues. We performed 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyl tetrazolium bromide assays, colony‐formation Cellomics ArrayScan Infinity analysis to...
Abstract Necroptosis is a programmed necrosis in caspase‐independent fashion. The role of necroptosis‐related genes (NRGs) lung cancer remains unknow. Herein, we classified TCGA‐LUAD cohort into two subtypes (C1 and C2) by consensus clustering analysis. result showed that subtype C1 had favourable prognosis higher infiltration levels immune cells. Moreover, was more activated immune‐associated pathways. Then, established an NRG model (NRG score) composed six NRGs (RIPK3, MLKL, TLR2, TLR4,...
Cellular senescence is associated with tumorigenesis, and the subtype prognostic signatures of senescence-related genes (SRGs) in tumor microenvironment (TME) gut microbiota have not been fully determined. Analysis 91 SRGs obtained from GSEA MSigDB, mRNA sequencing Gene Expression Omnibus (GEO) The Cancer Genome Atlas (TCGA) databases enabled identification two distinct molecular types colorectal cancer (CRC). Patient samples were clustered into subtypes, Kaplan-Meier survival analyses...
Background. Pyroptosis is a form of cell death characterized by swelling and plasma membrane bubbling in association with inflammatory immune responses. To date, the between pyroptosis colorectal cancer remains unclear. We aimed to establish novel pyroptosis-associated model for prognosis cancer. Methods. Pyroptosis-related genes were extracted using Gene Set Enrichment Analysis. A least absolute shrinkage selection operator regression was constructed identify pyroptosis-related gene...
Abstract Phosphodiesterase 4D interacting protein (PDE4DIP) is a Golgi/centrosome-associated that plays critical roles in the regulation of microtubule dynamics and maintenance Golgi structure. However, its biological role human cancer remains largely unknown. In this study, we showed PDE4DIP overexpressed non-small cell lung (NSCLC) tissues upregulated expression associated with poor prognosis patients cancer. We demonstrated knockdown inhibits NSCLC proliferation vitro tumorigenicity vivo....
Liver transplantation is an effective measure to treat adult-onset type II citrullinemia (CTLN2). Active and perioperative nutrition support a very important treatment for the prognosis of such patients. In this paper, we analyzed process, results, outcome nutritional therapy in case CTLN2, concluded that program CTLN2 patients should be followed prior surgery:1.because prevalence severe malnutrition patients, Enteral (EN) combined with Parenteral (PN) first choice support; 2. daily energy...
Abstract Background The burden of chronic respiratory diseases has changed over three decades.To describe the spatiotemporal trends prevalence, mortality and disability adjusted life years (DALY) due to diseases(CRDs), across globe during 1990–2019 using data from Global Burden Disease Study 2019(GBD 2019). Methods DALY attributable CRDs, risk factors 1990 2019 were estimated. We also assessed driving potentiality for improvement by decomposition analyses frontier analyses. Results In 2019,...
Abstract Background The burden of chronic respiratory diseases has changed over three decades.To describe the spatiotemporal trends prevalence, mortality and disability adjusted life years (DALY) due to diseases(CRDs), across globe during 1990–2019 using data from Global Burden Disease Study 2019(GBD 2019). Methods DALY attributable CRDs, risk factors 1990 2019 were estimated. We also assessed driving potentiality for improvement by decomposition analyses frontier analyses. Results In 2019,...
e20074 Background: Carboxypepidase A4 (CPA4) is a member of the metallocarboxypeptidase family. Previous study discovered that CPA4 may participate in cell growth and differentiation prostate epithelial cells. Meanwhile, printed gene thought to be involved cancer aggressiveness. As reported, was increased NSCLC tissues compared normal lung high expression correlated with poor prognosis patients. However, role play tumorigenesis still unclear. Methods: We examined mRNA protein level via...