A5102020683- Cancer-related gene regulation
- Phytochemical Studies and Bioactivities
- RNA modifications and cancer
- Phytochemistry and Bioactive Compounds
- Cancer-related molecular mechanisms research
- Metabolism and Genetic Disorders
- Organ Donation and Transplantation
- Pancreatic function and diabetes
- Renal and related cancers
- Phytochemistry and Biological Activities
- Ferroptosis and cancer prognosis
- Retinoids in leukemia and cellular processes
- Pluripotent Stem Cells Research
- TGF-β signaling in diseases
- Epigenetics and DNA Methylation
- Liver physiology and pathology
- Traditional Chinese Medicine Analysis
- Fluoride Effects and Removal
- Tissue Engineering and Regenerative Medicine
- Insect Resistance and Genetics
- Cancer Mechanisms and Therapy
- Gout, Hyperuricemia, Uric Acid
- Electromagnetic Fields and Biological Effects
- Axon Guidance and Neuronal Signaling
- Cytokine Signaling Pathways and Interactions
Southwest Minzu University
2025
Guiyang Medical University
2025
Affiliated Hospital of Qingdao University
2022-2025
Qingdao University
2022-2025
Nanjing Drum Tower Hospital
2024
Shandong University of Traditional Chinese Medicine
2021-2023
Yale Cancer Center
2022-2023
Yale University
2022-2023
Women's Hospital, School of Medicine, Zhejiang University
2020
University of Pittsburgh
2015-2019
The cause of organ failure is enigmatic for many degenerative diseases, including end-stage liver disease. Here, using a CCl4-induced rat model irreversible and fatal hepatic failure, which also exhibits terminal changes in the extracellular matrix, we demonstrated that chronic injury stably reprograms critical balance transcription factors diseased dedifferentiated cells can be returned to normal function by re-expression factors, process similar type reprogramming induces somatic become...
In the classical form of α1-antitrypsin deficiency (ATD), aberrant intracellular accumulation misfolded mutant Z (ATZ) in hepatocytes causes hepatic damage by a gain-of-function, "proteotoxic" mechanism. Whereas some ATD patients develop severe liver disease (SLD) that necessitates transplantation, others with same genetic defect completely escape this clinical phenotype. We investigated whether induced pluripotent stem cells (iPSCs) from individuals or without SLD could model these...
A fundamental feature of cell signaling is the conversion extracellular signals into adaptive transcriptional responses. The role RNA modifications in this process poorly understood. small nuclear 7SK prevents elongation by sequestering cyclin dependent kinase 9/cyclin T1 (CDK9/CCNT1) positive transcription factor (P-TEFb) complex. We found that epidermal growth induces phosphorylation enzyme methyltransferase 3 (METTL3), leading to METTL3-mediated methylation 7SK. enhanced its binding...
TGFβ-induced (TGFBI/βig-H3) is a protein inducible by TGFβ1 and secreted many types of cells. It binds to collagen, forms part the extracellular matrix (ECM), interacts with integrins on cell surfaces. In this study, we investigated role TGFBI in tumorigenesis underlying mechanisms.Patient serum levels were determined ELISA. transgenic gene knockout mice TGFBI-overexpressing liver cells used for mechanistic studies.We demonstrated that patients cholangiocarcinomas, hepatic carcinomas or...
Abstract TR6/DcR3/M68 is a soluble receptor that belongs to the TNF family. It expressed in malignant cells of several tumor types and has been postulated help gain survival advantage by inhibiting apoptosis interfering with immune surveillance. In our study, we assessed for first time serum TR6 patients explore its diagnostic prognostic value. We examined levels ELISA 146 patients, 19 acute infection, 5 liver cirrhosis 29 healthy individuals. expression mass was studied...
Erythropoietin-producing hepatocellular kinases (Eph kinases) constitute the largest family of cell membrane receptor tyrosine kinases, and their ligand ephrins are also surface molecules. Because promiscuous interaction between Ephs ephrins, there is considerable redundancy in this system, reflecting essential roles these molecules biological system through evolution. In study, both Efnb1 Efnb2 were null-mutated T compartment mice loxP-mediated gene deletion. Mice with double conditional...
541 Background: To investigate the prognosis and influencing factors of patients with unresectable hepatocellular carcinoma (uHCC) receiving regorafenib in different treatment modes. Methods: A total 227 uHCC who received at least 2 cycles Affiliated Hospital Qingdao University between June 2018 August 2022 were retrospectively collected through Information System (HIS). 204 finally enrolled by inclusion exclusion criteria after screening. Results: The median follow-up was 25.9 (4.5-69.7)...
Galangin (GAL), a flavonol found in Alpinia officinarum and propolis, is promising functional food. This study investigated the therapeutic effects mechanisms of GAL mice with hyperuricemic nephropathy (HN) by focusing on renal metabolomics network pharmacology. In this study, we conducted untargeted metabolomic analysis pharmacology prediction. Subsequently, compound-reaction-enzyme-gene was constructed based results to elucidate potential connections. The demonstrated that can improve...
Stem cell-derived organoids are emerging as sophisticated models for studying development and disease potential sources developing organ substitutes. Unfortunately, although containing renal structures have been generated from mouse human pluripotent stem cells, there still critical unanswered questions that difficult to attain via in vitro systems, including whether these nonvascularized a stable physiologically relevant phenotype or suitable transplantation site long-term vivo studies can...
Essential hypertension (EH) is a leading cause of cardiovascular morbidity and mortality. Fructus Tribuli (FT), as traditional medicine, has been frequently used for thousands years. The crude (CFT), decoction pieces being processed to remove impurities, have listed an important medicine the treatment in elderly. According theory Chinese CFT can enhance EH after stir-fried into (SFT). At present, whether SFT its potential pharmacodynamic substances mechanism are unknown. In this study,...
Abstract Objective Decoy receptor 3 (DcR3), a tumor necrosis factor family member, is secreted protein that can enhance cell survival by interfering with multiple apoptosis pathways. This study was undertaken to investigate the role of DcR3 in pathogenesis autoimmune disease. Methods We generated transgenic mice actin promoter–driven expression human and investigated development disease these mice. Results T immune responses were compromised young DcR3‐transgenic Beyond 5–6 months age,...
The purpose of this study was to illustrate the mechanism "enzyme inactivation and toxicity reduction" Fructus Tribuli (FT) after being heating processed. Ultra-high performance liquid chromatography coupled with triple quadrupole tandem mass spectrometry (UHPLC-MS/MS) used quantitatively analyze contents four steroidal saponins in crude (CFT) stir-fried (SFT) under different storage times at room temperature. enzyme activity β-D-glucosidase CFT SFT were determined calculated by...
Liver transplantation is an effective measure to treat adult-onset type II citrullinemia (CTLN2). Active and perioperative nutrition support a very important treatment for the prognosis of such patients. In this paper, we analyzed process, results, outcome nutritional therapy in case CTLN2, concluded that program CTLN2 patients should be followed prior surgery:1.because prevalence severe malnutrition patients, Enteral (EN) combined with Parenteral (PN) first choice support; 2. daily energy...
Abstract The effectiveness of cell-based therapies to treat liver failure is limited by the diseased environment. Herein we provide preclinical proof-of-concept for treatment through hepatocyte transplantation into lymph nodes in a large-animal model hereditary tyrosinemia type 1 (HT1), metabolic disease caused deficiency fumarylacetoacetate hydrolase (FAH) enzyme. FAH-deficient pigs received autologous mesenteric after ex vivo transduction with lentiviral vector carrying pig Fah gene....
Objective To observe expression of the keratin 10 (K10), c-myc and cox2 in buccal mucous membrane exfoliated cells, changes liver function coal-burning arsenism patients, order to explorate arsenic poison circumference biology symbol. Methods The cells were collected from both patients normal controls. Real-time PCR was employed detect K10, c-myc, genes these cells. Simultaneously, venous blood extracted examinated function. Results K10 found obviously overexpressed patients(3.60±0.94)...