A5101652221- Advanced Neuroimaging Techniques and Applications
- MicroRNA in disease regulation
- Functional Brain Connectivity Studies
- Cerebrospinal fluid and hydrocephalus
- Dementia and Cognitive Impairment Research
- Cerebrovascular and Carotid Artery Diseases
- Cancer-related molecular mechanisms research
- Intracerebral and Subarachnoid Hemorrhage Research
- Acute Ischemic Stroke Management
- RNA modifications and cancer
- Alzheimer's disease research and treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Fetal and Pediatric Neurological Disorders
- Gut microbiota and health
- Immune Response and Inflammation
- Advanced MRI Techniques and Applications
- Neurological Disease Mechanisms and Treatments
- Aquaculture Nutrition and Growth
- Spinal Dysraphism and Malformations
- Marine Bivalve and Aquaculture Studies
- Liver Disease Diagnosis and Treatment
- Antioxidant Activity and Oxidative Stress
- Traumatic Brain Injury and Neurovascular Disturbances
- Pancreatic function and diabetes
- Cholesterol and Lipid Metabolism
Shanghai University of International Business and Economics
2025
Beijing Institute of Technology
2025
Changchun University of Technology
2024-2025
Zhejiang University
2021-2025
Second Affiliated Hospital of Zhejiang University
2019-2024
Northeast Normal University
2017-2024
Central Hospital of Wuhan
2024
Henan Provincial People's Hospital
2024
Henan University
2024
Zhengzhou University
2024
Abstract Background Glymphatic dysfunction is a crucial pathway for dementia. Alzheimer’s disease (AD) pathologies co-existing with cerebral small vessel (CSVD) the most common pathogenesis We hypothesize that AD and CSVD could be associated glymphatic dysfunction, contributing to cognitive impairment. Method Participants completed amyloid PET, diffusion tensor imaging (DTI), T2 fluid-attenuated inversion-recovery (FLAIR) sequences were included from Disease Neuroimaging Initiative (ADNI)....
Despite the approval of several artificial nanotherapeutics for treatment triple-negative breast cancer (TNBC), significant challenges, including unsatisfactory therapeutic outcomes, severe side effects, and high cost large-scale production, still restrict their long-term application. In contrast, plant-derived extracellular vesicles (PEVs) exhibit promising potential in therapy due to negligible systemic toxicity, bioavailability cost- effectiveness. this study, we developed an alternative...
Abstract Background and aims Human umbilical cord mesenchymal stem cells (hUC-MSCs) are increasingly being studied in clinical trials of end-stage liver disease because their good tissue repair anti-inflammatory effects. hUC-MSC exosomes vesicles with spherical structures secreted by that produce them. The diameter is much smaller than hUC-MSCs, suggesting might be a novel safer therapeutic product cells. As have been suggested to biochemical functions similar those this study investigated...
Ovarian cancer (OC) is known for its high mortality rate. Although sodium citrate has anti-tumor effects in various cancers, effect and mechanism OC remain unclear. To analyze the inhibitory of on ovarian cells underlying mechanism. Cell apoptosis was examined by TUNEL staining, flow cytometry ferroptosis intracellular Fe2+, MDA, LPO assays respectively. metabolism OCR ECAR measurements. Immunoblotting immunoprecipitation were used to elucidate This study suggested that not only promoted...
Arterial pulsation has been suggested as a key driver of paravascular cerebrospinal fluid flow, which is the foundation glymphatic clearance. However, whether intracranial arterial pulsatility associated with markers in humans not yet studied. Seventy-three community participants were enrolled study. 4D phase-contrast magnetic resonance imaging (MRI) was used to quantify hemodynamic parameters including flow index (PIflow) and area (PIarea) from 13 major intracerebral segments. Three...
The present study was conducted to investigate the possible association between gut microbes and immunity among healthy middle-aged elderly individuals in southwest China. A total of 148 adults aged ≥ 50 years were divided into two age groups: group (50-59 years; n = 67, 54.13 ± 3.32) (≥ 60 81, 64.70 3.93). Blood samples collected measure serum immune biochemical indices. Gut microbiota compositions groups characterized on basis faecal DNA using 16S rRNA gene sequencing.Among detected...
Assessing glymphatic function using in-vivo imaging method is of great value for understanding its contribution to major brain diseases. In the present study, we aim validate association between a variety risk factors and potential index function—Diffusion Tensor Image Analysis Along Perivascular Space (ALPS index). We enrolled 142 subjects from communities performed multi-modality magnetic resonance scans. The ALPS was calculated diffusion tensor data, associations with demographic factors,...
Understanding the pathophysiology of white matter hyperintensity (WMH) is necessary to reduce its harmfulness. Dilated perivascular space (PVS) had been found related WMH. In present study, we aimed examine topological connections between WMH and PVS, investigate whether increased interstitial fluid mediates correlation PVS volumes. One hundred thirty-six healthy elder subjects were retrospectively included from a prospectively collected community cohort. Sub-millimeter T2 weighted FLAIR...
Glymphatic dysfunction may contribute to the accumulation of Alzheimer's disease (AD) pathologies. Conversely, AD pathologic change might also cause neuroinflammation and aggravate glymphatic dysfunction, forming a loop that accelerates progression. In vivo validations are needed confirm their relationships.In this study, we included 144 cognitively normal participants with pathological biomarker data (baseline CSF Aβ1-42, T-Tau, P-Tau181; plasma P-Tau181 at baseline least one follow-up)...
Abstract The integrity of the intestinal mucosal barrier is crucial for protecting epithelium against invasion by commensal bacteria and pathogens, thereby combating colitis. investigation revealed that absence TSP50 compromised in murine subjects. This disruption facilitated direct contact between epithelium, increasing susceptibility to Mechanistic analysis indicated deficiency stem cells (ISCs) triggered aberrant activation TGF‐β signaling pathway impeded differentiation goblet mice,...
Dietary assessments hold significant importance within the field of public health. However, current methods employed for dietary face certain limitations and challenges that necessitate improvement. The aim our study was to develop a reliable practical assessment tool known as photo-assisted intake (PAD). In order evaluate its validity, we conducted an analysis on sample 71 college students' dinners at buffet in canteen. We compared estimates food weights obtained through 24-h recall (24 HR)...
Deep medullary veins (DMVs) participate in the drainage of surrounding white matter. In cerebral small vessel disease (CSVD), disrupted DMVs were often observed together with damaged matter, but phenomenon lacked validation and explanation. We hypothesized that venous disruption might cause matter damage through increased interstitial fluid resulting from hemodynamic alteration, we designed a comprehensive multi-modality MRI study to testify our hypothesis. Susceptibility-weighted imaging...
As lipid microconstituents mainly of plant origin, carotenoids are essential nutrients for humans and animals, carotenoid coloration represents an important meat quality parameter many farmed animals. Currently, the mechanism bioavailability in animals is largely unknown due to limited approaches applied, shortage suitable model systems restricted taxonomic focus. The mollusk Yesso scallop (Patinopecten yessoensis) possessing orange adductor muscle with deposition, provides a unique...
Background: The dilation of perivascular space (PVS) has been widely used to reflect brain degeneration in clinical imaging studies. However, PVS characteristics exhibit large differences healthy subjects. Such variations need be better addressed before can pathological changes. In the present study, we aim investigate potential influence several related factors on elderly Methods: One-hundred and three subjects (mean age = 59.5) were retrospectively included from a prospectively collected...
Abstract Recurrence and metastasis are the main causes of breast cancer (BRCA)-related death remain a challenge for treatment. In-depth research on molecular mechanisms underlying BRCA progression has been an important basis developing precise biomarkers therapy targets early prediction treatment progressed BRCA. Herein, we identified FERM domain-containing protein 3 (FRMD3) as novel potent tumor suppressor which is significantly downregulated in clinical tissue cell lines, low FRMD3...