A5101959647- Rheumatoid Arthritis Research and Therapies
- Pharmacological Effects of Natural Compounds
- Liver Disease Diagnosis and Treatment
- Plant-derived Lignans Synthesis and Bioactivity
- Medicinal Plant Pharmacodynamics Research
- Inflammatory mediators and NSAID effects
- Urinary Bladder and Prostate Research
- Plant-based Medicinal Research
- Endoplasmic Reticulum Stress and Disease
- Immune Response and Inflammation
- Cardiovascular Issues in Pregnancy
- Biomedical Research and Pathophysiology
- Healthcare and Venom Research
- Phagocytosis and Immune Regulation
- Inflammasome and immune disorders
- Ocular Diseases and Behçet’s Syndrome
- Oral Health Pathology and Treatment
- Phytochemistry and Bioactivity Studies
- Acute Kidney Injury Research
- Pancreatitis Pathology and Treatment
- Traditional Chinese Medicine Studies
- Adipose Tissue and Metabolism
- Oral and Maxillofacial Pathology
- Ginger and Zingiberaceae research
- Chronic Kidney Disease and Diabetes
Wenzhou Medical University
2020-2025
Hunan University of Traditional Chinese Medicine
2017-2021
Jilin University
2019-2021
Shanghai Changzheng Hospital
2019
Shanghai Ninth People's Hospital
2018
Shanghai First People's Hospital
2016
Second Affiliated Hospital of Fujian Medical University
2015
Fujian Medical University
2015
Rheumatoid arthritis (RA) is a systemic autoimmune disease underlying cascade of chronic inflammatory processes. Over the past decades, response rate effective RA treatments has remained scarce despite numerous advancements in current therapeutic interventions, owing largely to associated off-target adverse events and poor accumulation inflamed joints. Recently, there high interest development targeted drug delivery system by using nanotechnology, as it can provide handle improve therapy...
Kaempferia rhizome is a famous traditional herbal medical in tropical and subtropical areas. Kaempferol (KPF) one of the main bioactive compounds rhizome, with anti-oxidant/anti-inflammatory effects demonstrated various disease models, including cancers, obesity diabetes. Inflammation plays an important role pathogenesis diabetic nephropathy (DN). TRAF6 functions as signal transducer toll-like receptor 4 NF-κB pro-inflammatory signaling pathway. We aimed at investigate whether KPF able to...
Objective . Toll-like receptor 9 (TLR9) is involved in many inflammatory diseases, but its role atherosclerosis remains controversial. This study aimed to investigate the of TLR9 development and macrophage polarization. Methods ApoE −/− mice were treated with vehicle or IRS869 for 12 weeks. Plaque vulnerability was assessed immunohistochemical analysis, picro-sirius red, oil red O staining. The expressions M1- M2-associated markers plaques detected by RT-PCR immunofluorescence. aorta...
Obesity has been recognized as a major risk factor for the development of chronic kidney disease, which is accompanied by increased renal inflammation, fibrosis, and apoptosis. C66 curcumin derivative that exerts anti-inflammatory effects inhibiting JNK pathway prevents diabetic nephropathy. The present study investigates possible protective effect on high-fat diet (HFD)-induced obesity-related glomerulopathy. Mice were fed with HFD 8 weeks while some treated every 2 days 11 weeks. HFD-fed...
Background . Administration of nonsteroidal anti‐inflammatory drugs (NSAIDs) often causes small intestinal ulcers in patients, but few effective are currently available to manage such serious adverse events NSAIDs. Li‐Zhong decoction (LZD), a well‐known traditional Chinese medicine (TCM) formula, is commonly prescribed for treatment gastrointestinal diseases. The present study aimed investigate the anti‐ulcerogenic activity LZD on indomethacin‐ (IND‐) induced duodenal ulcer rats. Mechanistic...
<b><i>Background:</i></b> Inflammation plays an important role in polycystic kidney disease (PKD). Cordyceps sinensis, a prized Chinese medicinal herb, exerts anti-tumor, anti-inflammatory and anti-metastatic effects benefits patients with diseases. The aim of this study was to test the efficacy FTY720, immunosuppressant derived from C. rat cystic model, explore its underlining mechanism. <b><i>Methods:</i></b> Male wild type Cy/+ Han:SPRD...
Rheumatoid arthritis (RA) is a common autoimmune disease characterized by progressive joint inflammation and destruction, deformity, loss of mobility, permanent disability. Although the cellular molecular mechanisms involved in RA are understood detail, no drugs or therapies can completely cure RA. Many long-term efforts have been directed towards better understanding pathogenesis development new classes therapeutics. Thus, ongoing elucidation pathogenic events underlying mostly relies on...
Atmospheric PM2.5 can induce airway inflammation and mucin secretion. MUC5B is required for defense. However, the research on role of in induced by atmospheric remains limited. This study was designed to explore PM2.5. In vivo, Wistar rats were exposed 0, 1.5, 7.5, 37.5 mg/ kg saline suspension via intratracheal instillation. HE staining AB-PAS used observe goblet cell hyperplasia. vitro, normal A549 cells MUC5B-knockdown 100, 200 400 μg/mL 6 h, 12 24 h 48 h. ELISA measure levels TNF-α IL-1β...
Hypothyroidism was a rare cause of rhabdomyolysis, which finally progressed to acute kidney injury (AKI). We compared nine patients with AKI secondary hypothyroidism and six severe hypothyroidism. Besides creatine kinase, globulin could be an alternative biomarker rhabdomyolysis related
ObjectiveQing Fu Juan Bi Tang (QFJBT) is an anti-arthritic Chinese medicine formula consisting of five herbs: Aconiti Lateralis Radix Praeparata (Fu Zi, 附子), Sinomenii Caulis (Qing Feng Teng, 青风藤), Astragali (Huang Qi, 黄芪), Paeoniae Alba (Bai Shao, 白芍) and Moutan Cortex (Mu Dan Pi, 牡丹皮), which have well-established histories use for treatment rheumatic arthritic diseases. We intended to establish the optimized standardized pharmaceutical procedures manufacturing processes pilot production...
To analyze the in-hospital mortality and factors affecting for patients with transposition of great arteries (TGA) undergoing arterial switch operation (ASO).Between January 2004 December 2007, ASO was performed in 169 [129 male, 40 female; mean age (11.71 ± 26.3) months] TGA. The were divided intact ventricular septum group (n = 56): TGA septal defect 113): defect. Multiple logistic regression analysis to identify risk mortality.The overall 11.24% (19/169). yearly similar between group....
Objective To investigate and characterize the serum metabolite profile of patients with rheumatoid arthritis (RA), a common autoimmune disease, which will be help for early diagnosis in clinic. Methods Serum specimens from 26 RA 19 age-matched healthy volunteers were collected First Affiliated Hospital Hunan University Chinese Medicine January through April 2015. Samples detected on gas chromatography-mass spectrometry (GC-MS), metabolites identified by chemometric methods....