A5081527781- Endometriosis Research and Treatment
- Endometrial and Cervical Cancer Treatments
- Uterine Myomas and Treatments
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Gut microbiota and health
- Cancer-related gene regulation
- MicroRNA in disease regulation
- Intergenerational Family Dynamics and Caregiving
- Head and Neck Cancer Studies
- Gynecological conditions and treatments
- Burn Injury Management and Outcomes
- Cancer Risks and Factors
- Advanced Photocatalysis Techniques
- Emotions and Moral Behavior
- Redox biology and oxidative stress
- NMR spectroscopy and applications
- Vascular Tumors and Angiosarcomas
- Metastasis and carcinoma case studies
- Lymphoma Diagnosis and Treatment
- Thyroid Cancer Diagnosis and Treatment
- Helicobacter pylori-related gastroenterology studies
- Systemic Lupus Erythematosus Research
- Sleep and related disorders
- Advanced biosensing and bioanalysis techniques
University of Science and Technology of China
2023-2024
The First Affiliated Hospital, Sun Yat-sen University
2024
Sun Yat-sen University
2024
Army Medical University
2014-2024
Suzhou Vocational Health College
2024
Harbin Medical University
2024
Third Affiliated Hospital of Harbin Medical University
2024
Air Force Medical University
2024
Northeast Normal University
2024
Sichuan University
2024
Abstract Programmed cell death (PCD) is a basic process of life that closely related to the growth, development, aging and disease organisms one hotspots science research today. PCD kind genetic control, autonomous orderly important involves activation, expression, regulation series genes. In recent years, with deepening in this field, new mechanisms multiple pathways have been revealed. This article reviews summarizes discovered, analyses compares morphological characteristics biomarkers...
Ovarian cancer (OC) is known for its high mortality rate. Although sodium citrate has anti-tumor effects in various cancers, effect and mechanism OC remain unclear. To analyze the inhibitory of on ovarian cells underlying mechanism. Cell apoptosis was examined by TUNEL staining, flow cytometry ferroptosis intracellular Fe2+, MDA, LPO assays respectively. metabolism OCR ECAR measurements. Immunoblotting immunoprecipitation were used to elucidate This study suggested that not only promoted...
miR-186-5p has been reported to be implicated in tumorigenesis and paclitaxel resistance non-small-cell lung cancer cells (NSCLCs). However, it remains undisclosed whether takes a part chemoresistance against diaminodichloroplatinum (cisplatin, DDP) cancers, including NSCLC. Expression of sine oculis homeobox 1 (SIX1) was detected using RT-qPCR western blot. In vitro, 50% inhibitory concentration (IC50) DDP cell proliferation were measured by MTT assay. The rate apoptosis abilities migration...
Proper timing of vigilance states serves fundamental brain functions. Although disturbance sleep onset rapid eye movement (SOREM) is frequently reported after orexin deficiency, their causal relationship still remains elusive. Here, we further study a specific subgroup neurons with convergent projection to the REM promoting sublaterodorsal tegmental nucleus (OX SLD neurons). Intriguingly, although OX and other projection-labeled exhibit similar activity dynamics during sleep, only activation...
With the treatment of nasopharyngeal carcinoma (NPC) by PD-1/PD-L1 inhibitors used widely in clinic, it becomes very necessary to anticipate whether patients would benefit from it. We aimed develop a nomogram evaluate efficacy anti-PD-1/PD-L1 NPC patients.
Chronic kidney disease (CKD) is a progressive disorder characterized by renal fibrosis, inflammation, and dysregulated autophagy apoptosis. High-mobility group box 1 (HMGB1) plays crucial role in regulating CKD. Hirudin, potent thrombin inhibitor, has demonstrated antifibrotic anti-inflammatory properties, but its effects on apoptosis CKD remain unclear. In this study, rat model of interstitial fibrosis (RIF) an HK-2 cell culture were established to assess the varying doses hirudin HMGB1...
The major drawback of the current common bile duct ligation (CBDL)-induced hepatopulmonary syndrome (HPS) animal model is extremely high mortality rate that hinders experimental studies. purpose this study was to investigate an improved method CBDL with goal developing a simple and reproducible rat HPS after single treatment. Two groups male Sprague–Dawley rats underwent separate methods CBDL: (1) upper (UCBDL) group ( n = 40), in which first ligature made near junction hepatic ducts, second...
Abstract It is of great importance to endow personal protective equipments with bactericidal property combating against infected pathogens. Nanozyme that can generate reactive oxygen species (ROS) in an enzyme‐catalytic manner regarded as a novel and promising nanobactericide. But until now, very rare them designed specifically for equipments. In this study, multinanozyme manganese oxide supported on Ce‐containing MOF (CeBTC) constructed post‐engineering via quasi‐metal‐organic framework...
Abstract Transumbilical single-port laparoscopy is widely used in gynecological surgery. However, it rarely the treatment of deep infiltrating endometriosis due to its own shortcomings and complex condition endometriosis. The study aims introduce a transumbilical laparoscopic surgery based on retroperitoneal pelvic spaces anatomy, which can complete operation more easily. A retrospective analysis 63 patients with treated by using this method was conducted. duration 120.00 (85.00 ± 170.00)...
Objective Studies in animal models have indicated that Pellino 1 is involved inflammatory and autoimmune diseases, such as systemic lupus erythematosus (SLE). The current study was designed to determine whether PELI1 confers genetic susceptibility SLE humans, assessed a Chinese Han population. Methods Blood samples were drawn from patients diagnosed with healthy volunteers. Three single nucleotide polymorphism (SNP) loci minor allele frequency of at least 0.05 chosen evaluate the correlation...
<title>Abstract</title> <bold>Objective</bold> Screen the relevant diagnostic indicators of endometriosis, build a model and verify it, so as to provide scientific basis for diagnosis differentiation.zig. <bold>Method(s)</bold> A total 625 patients with pathologically confirmed endometriosis were selected from December 2016 June 2022 in Hainan Provincial people's Hospital. 308 case group 317 without control group. There 41 cases 28 The clinical characteristics laboratory indexes compared:...
To investigate the application effects of armor chest straps in patients with sternal dehiscence after repair surgery.
<h3>Background:</h3> Ankylosing spondylitis (AS) is an autoimmune disorder linked to the human leukocyte antigen B27 (HLA-B27) gene. While abnormal composition of gut microbiome and its related disturbed metabolites may co-contribute AS, relationship between HLA-B27, microbiota, their in AS patients still largely uncharted. <h3>Objectives:</h3> We sought further investigate patients. <h3>Methods:</h3> conducted integrated analysis metabolome, examining 88 fecal samples across three groups:...
Background Relapsed/Refractory (R/R) diffuse large B-cell lymphoma (DLBCL) represents a subgroup with high incidence and dismal prognosis. Currently, there is lack of robust models for predicting R/R DLBCL. Therefore, we conducted retrospective study to identify key determinants be incorporated into novel nomogram enhance the identification DLBCL patients at elevated risk refractoriness/recurrence.
Shale oil and gas, as source-reservoir-type resources, result from organic matter hydrocarbon generation, diagenesis, nanoscale pore during the evolution processes, which are essential aspects of shale gas enrichment reservoir formation. To investigate impact diagenetic hydrocarbons on heterogeneity, a thermal simulation formation was conducted immature Middle Proterozoic Xiamaling Formation in Zhangjiakou area, covering stages mature to overmature. Nuclear magnetic resonance (NMR)...
Objective: To evaluate the oncologic outcomes of different laparoscopic radical hysterectomy. Methods: From January 2011 to December 2014, operation cases cervical cancer at stage Ⅰb1, Ⅰb2, Ⅱa1 and Ⅱa2, including histologic subtypes squamous-cell carcinoma, adenocarcinoma adenosquamous were collected in five clinical centers. The data divided into two groups according surgical procedures, that is, modified laparoscopic-vaginal hysterectomy (mLVRH) total (TLRH). overall survival rate (OS),...
Objective: To investigate the epidemiological characteristics and etiological distribution of infection on 3 067 hospitalized pediatric patients with burns, explore prevention treatment strategy burns. Methods: A cross-sectional survey was conducted. An analysis performed data burns who met inclusion criteria were admitted to First Affiliated Hospital Army Medical University (the Third Military University) from January 2012 December 2020, including gender, age, causative factors, locations...
Abstract Purpose Radioactive Iodine ( 131 I) (RAI) therapy is a conventional post-surgery treatment widely used for papillary thyroid carcinoma (PTC). Since I orally administered, we hypothesize that it may affect gut microbiome. This study aims to investigate alterations of intestinal microbiome after in PTC patients and explore its association with response therapy. Methods Fecal samples 60 pre- post- were collected characterize the RAI-induced microbiota using 16S rRNA gene sequencing....