A5015105956- Signaling Pathways in Disease
- MicroRNA in disease regulation
- Anesthesia and Neurotoxicity Research
- Balance, Gait, and Falls Prevention
- Calpain Protease Function and Regulation
- Parkinson's Disease Mechanisms and Treatments
- Anesthesia and Sedative Agents
- Neonatal Respiratory Health Research
- Pharmacological Effects of Natural Compounds
- Cerebral Palsy and Movement Disorders
- Respiratory Support and Mechanisms
- Liver Disease and Transplantation
- Radiomics and Machine Learning in Medical Imaging
- RNA modifications and cancer
- Airway Management and Intubation Techniques
- Cancer Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Spine and Intervertebral Disc Pathology
- Intensive Care Unit Cognitive Disorders
- Hematopoietic Stem Cell Transplantation
- Peptidase Inhibition and Analysis
- Circular RNAs in diseases
- Congenital Diaphragmatic Hernia Studies
- Anesthesia and Pain Management
- Biochemical and Molecular Research
Chaohu University
2025
Dongfeng General Hospital
2025
China National Pharmaceutical Group Corporation (China)
2025
Hubei University of Medicine
2025
Orthopaedic Trauma Association
2023
Henan University
2021-2023
Southwest Hospital
2013-2022
Army Medical University
2005-2022
State Key Laboratory of Cotton Biology
2022
Dongguan People’s Hospital
2021
Background Anorectal malignant melanoma is a rare subtype of with poor prognosis. Despite this, some patients decline Miles’ operation due to the sigmoid colostomies that follow abdominoperineal resections in cases anorectal melanoma. Case report We case an 80-year-old woman diagnosed who underwent cryosurgery accompanied by adjuvant PD-1 therapy maintain anal sphincter function. The results indicated we successfully achieved goal preservation and therapeutic efficacy. patient derived...
The major drawback of the current common bile duct ligation (CBDL)-induced hepatopulmonary syndrome (HPS) animal model is extremely high mortality rate that hinders experimental studies. purpose this study was to investigate an improved method CBDL with goal developing a simple and reproducible rat HPS after single treatment. Two groups male Sprague–Dawley rats underwent separate methods CBDL: (1) upper (UCBDL) group ( n = 40), in which first ligature made near junction hepatic ducts, second...
Journal Article A novel locus (DSAP2) for disseminated superficial actinic porokeratosis maps to chromosome 15q25.1–26.1 Get access K. Xia, Xia National Laboratory of Medical Genetics K.Xia. E‐mail: nlmglcy@xymu.net Search other works by this author on: Oxford Academic Google Scholar H. Deng, Deng J.H. D. Zheng, Zheng H.L. Zhang, Zhang C.Y. Lu, Lu C.Q. Li, Li Department Dermatology, Xiangya Hospital, and Q. Pan, Pan H.P. Dai, Dai Y.F. Yang, Yang Thoracic Surgery, Second Central South...
Recently, miR-221-3p expression has been reported to be down-regulated in medulloblastoma (MB), but its functional effects remains unclear. In this study, quantitative real-time PCR (qRT-PCR) revealed significantly decreased MB cell lines. Transfection of mimics reduced, or inhibitor increased proliferation cells using MTT assay. Flow cytometry analysis indicated overexpression promoted, while knockdown alleviated G0/G1 arrest and apoptosis. Luciferase reporter assay confirmed directly...
Common bile duct ligation (CBDL) rats is an accepted experimental model of hepatopulmonary syndrome (HPS), defined as liver disease and intrapulmonary vascular dilatation hypoxaemia. Pulmonary Akt ERK activation followed by angiogenesis in the later stages CBDL, contribute to pathogenesis HPS. However, mechanisms behind remain undefined. injury induced increased bilirubin, endotoxin inflammatory mediators occurs early CBDL. We assessed effects relieving pulmonary on development HPS following...
Abstract Hepatopulmonary syndrome (HPS) markedly increases the mortality of patients. However, its pathogenesis remains incompletely understood. Rat HPS develops in common bile duct ligation (CBDL)‐induced, but not thioacetamide (TAA)‐induced cirrhosis. We investigated mechanisms by comparing these two models. Pulmonary histology, blood gas exchange, and related signals regulating macrophage accumulation were assessed CBDL TAA rats. Anti‐polymorphonuclear leukocyte (antiPMN)...
Hepatopulmonary syndrome (HPS) is a triad of advanced liver disease, intrapulmonary vasodilatation and arterial hypoxemia. Increasing evidence shows that HPS associated with pulmonary microvascular hyperplasia. The aim this work was to investigate the underlying mechanism miR-145 in regulating proliferation endothelial cells (PMVECs) angiogenesis via plasminogen activator inhibitor-1 (PAI-1). To test this, morphology score number were assessed lung tissues from rats by Hematoxylin Eosin...
TNF-α-induced protein 3-interacting 1 (TNIP1) is active in various cancers, but its expression and function renal cell carcinoma (RCC) have not been described. This study investigated the role of TNIP1 clear carcinomas (ccRCC), which accounts for 75-80% RCC has a poor prognosis.The human ccRCC tissues cells was detected by real-time quantitative reverse transcription-polymerase chain reaction (qRT-PCR), Western blot (WB), immunohistochemical (IHC) staining. Cell proliferation assayed...
Smith-Magenis syndrome (SMS) is a rare with multiple congenital malformations, including development and mental retardation, behavioral problems distinct facial appearance.SMS caused by haploinsufficiency of RAI1 (deletion or mutation RAI1).We describe an eight-year-old female Chinese patient heart defect, (self hugging, sleeping disturbance).High-resolution genome wide single nucleotide polymorphism array revealed 3.7-Mb deletion in chromosome region 17p11.2.This contains RAI1, critical...