A5101426730- Catalytic C–H Functionalization Methods
- Renal and related cancers
- Dementia and Cognitive Impairment Research
- Sulfur-Based Synthesis Techniques
- Alzheimer's disease research and treatments
- Advanced Neuroimaging Techniques and Applications
- Catalytic Cross-Coupling Reactions
- Functional Brain Connectivity Studies
- RNA and protein synthesis mechanisms
- Epigenetics and DNA Methylation
- Advanced MRI Techniques and Applications
- Asymmetric Hydrogenation and Catalysis
- CRISPR and Genetic Engineering
- Biosensors and Analytical Detection
- Microfluidic and Capillary Electrophoresis Applications
- Crystallization and Solubility Studies
- Electrocatalysts for Energy Conversion
- X-ray Diffraction in Crystallography
- Synthesis and biological activity
- Advanced Photocatalysis Techniques
- SARS-CoV-2 detection and testing
- Advanced biosensing and bioanalysis techniques
- Acute Ischemic Stroke Management
- Curcumin's Biomedical Applications
- Molecular Biology Techniques and Applications
Chengdu University
2019-2025
Hubei University of Chinese Medicine
2024-2025
Chinese Academy of Sciences
2020-2024
Second Affiliated Hospital of Zhejiang University
2020-2024
Fujian Agriculture and Forestry University
2024
Zhejiang University
2020-2024
Wuhan National Laboratory for Optoelectronics
2020-2024
Wuhan Institute of Physics and Mathematics
2020-2024
University of Chinese Academy of Sciences
2020-2024
Changchun Institute of Applied Chemistry
2023
Abstract Background The neuropathological hallmarks of Alzheimer’s disease (AD) are amyloid-β (Aβ) plaques and neurofibrillary tangles (NFTs). amyloid cascade theory is the leading hypothesis AD pathology. Aβ deposition precedes aggregation tau pathology precipitates Evidence also indicates reciprocal interactions between However, detailed relationship in remains elusive. Metformin might have a positive effect on cognitive impairments. whether metformin can reduce AD-related pathologies...
Abstract Revealing the energy transfer (ET) process from excitons to rare earth ions in halide perovskites has great guiding value for designing optoelectronic materials. Here, multiple ET channels multi‐exciton emissive Sb 3+ /Nd co‐doped Cs 2 ZrCl 6 are explored comprehend processes. Förster–Dexter theory reveals that sensitizer concentration rather than overlap integral of spectra plays leading function comparison efficiency among host self‐trapped (STEs) and dopant triplet STEs Nd ions....
Glymphatic dysfunction may contribute to the accumulation of Alzheimer's disease (AD) pathologies. Conversely, AD pathologic change might also cause neuroinflammation and aggravate glymphatic dysfunction, forming a loop that accelerates progression. In vivo validations are needed confirm their relationships.In this study, we included 144 cognitively normal participants with pathological biomarker data (baseline CSF Aβ1-42, T-Tau, P-Tau181; plasma P-Tau181 at baseline least one follow-up)...
Wilms' tumor gene WT1 is overexpressed in leukemia and various types of solid tumors plays an important role leukemogenesis tumorigenesis. We tested apoptosis-inducing ability short hairpin RNAs targeting exon 5 (shWTE5), exon10 (shWTE10) 3'UTR (shWT3U) the gene. Among three WT1-shRNAs, since shWTE5 most effectively induced apoptosis, its as agent was intensively examined. mitochondrial damage resultant apoptosis five WT1-expressing cancer cells originated from gastric (AZ-521), lung...
Biomacromolecular folding kinetics involves fast events and broad timescales. Current techniques face limitations in either the required time resolution or observation window. In this study, we developed TeZla micromixer, integrating Tesla Zigzag microstructures with a multistage velocity descending strategy. achieves significant short mixing dead (40 µs) wide window covering four orders of magnitude (up to 300 ms). Using unique explored landscape c-Myc G4 its noncanonical-G4 derivatives...
A transition-metal-free electrochemical chalcogenative cyclization of 2-alkynyl aryl oxime with dichalcogenides has been established to assemble valuable 4-organochalcogen isoquinolines concisely. This protocol proceeds via constant electrolysis in a user-friendly undivided cell setup. It circumvents the necessity transition metal catalysts, chemical oxidants, and harsh reaction conditions. The practical utilities current were illustrated by excellent functional group tolerance, remarkable...
The truncated TERRA sequence [UUAGGG] 3 forms a stable parallel RNA G-triplex structure and can be used as novel biosensing element.
Objective: To assess the value of Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) during acute phase in predicting post-stroke cognitive impairment (PSCI) at 3-6 months. Methods: We prospectively recruited 229 patients who had suffered their first-ever ischemic stroke. PSCI was determined 104 these by a comprehensive neuropsychological battery performed Receiver operating characteristic (ROC) curve analysis then to compare discriminatory ability MMSE MoCA. Also,...
Abstract A convenient and effective method of ruthenium‐catalyzed C−H/N−H annulations using vinylene carbonate as oxidizing acetylene surrogate has been disclosed. This is scalable compatible with a wide range functional groups, providing step‐economical access to indole synthesis Preliminary mechanistic studies provided support for reversible, acetate‐assisted C−H ruthenation, along subsequent olefin insertion. magnified image
Background: Predicting the prognosis of mild cognitive impairment (MCI) has outstanding clinical value, and hippocampal volume is a reliable imaging biomarker AD diagnosis. Objective: We aimed to longitudinally assess sub-regional difference (volume asymmetry) among progressive MCI (pMCI), stable (sMCI) patients, normal elderly. Methods: identified 29 pMCI, 52 sMCI, 102 controls (NC) from ADNI database. All participants underwent neuropsychological assessment 3T MRI scans three times. The...
Herein, we report a highly efficient ruthenium-catalyzed peri-selective C(sp2)–H acylmethylation of 1-naphthols with α-carbonyl sulfoxonium ylides by utilizing hydroxyl as weakly coordinating directing group. This new method imparts good reactivity, excellent chemo- and regioselectivity, broad functional group tolerance involves mild reaction conditions. The C–H acylmethylated products can be readily cyclized into fluorescent annulated pyrans one-pot process.
The regulation of the coordination environment central metal atom is considered as an alternative way to enhance performance single-atom catalysts (SACs). Herein, we design electrocatalyst with active sites isolated Co atoms coordinated four sulfur supported on N-doped carbon frameworks (Co1-S4/NC), confirmed by high-angle annular dark-field scanning transmission electron microscope (HADDF-STEM) and synchrotron-radiation-based X-ray absorption fine structure (XAFS) spectroscopy. Co1-S4/NC...
In this study, we investigated Cas13a's efficacy in
Neuropsychiatric symptoms (NPS) are prevalent in cognitively impaired individuals including Alzheimer's disease (AD) dementia and mild cognitive impairment (MCI). Whereas several studies have reported the associations between NPS with AD pathologic biomarkers cerebral small vessel (SVD), but it remains unknown whether pathology SVD contribute to different sub-syndromes independently or aggravate same synergistically. We included 445 (including 316 MCI 129 AD) neuropsychiatric, cerebrospinal...
Journal of Clinical Gastroenterology 40(10):p 959-963, November 2006. | DOI: 10.1097/01.cji.0000211337.91513.94
An efficient ruthenium-catalyzed direct C-H selenylation of aryl acetic amides and esters has been achieved via distal weakly coordination. Notable features this protocol including broad substrate scope, wide functional group tolerance, good regioselectivity. In addition, diaryl disulfides were also successfully applied to reaction under slightly modified conditions.