A5039448187- Bone health and treatments
- Cancer Treatment and Pharmacology
- Radiopharmaceutical Chemistry and Applications
- Sarcoma Diagnosis and Treatment
- PARP inhibition in cancer therapy
- Cancer Immunotherapy and Biomarkers
- MicroRNA in disease regulation
- Autophagy in Disease and Therapy
- CAR-T cell therapy research
- CRISPR and Genetic Engineering
- Cancer Cells and Metastasis
- Extracellular vesicles in disease
- Bone Metabolism and Diseases
- Graphene and Nanomaterials Applications
- Immunotherapy and Immune Responses
- Circular RNAs in diseases
- Cancer Genomics and Diagnostics
- Glycosylation and Glycoproteins Research
- Carbon and Quantum Dots Applications
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- Virus-based gene therapy research
- Galectins and Cancer Biology
- MXene and MAX Phase Materials
- Cancer Research and Treatments
Qingdao University
2019-2024
Affiliated Hospital of Qingdao University
2019-2024
Wuhan Institute of Physics and Mathematics
2024
Wuhan National Laboratory for Optoelectronics
2024
Chinese Academy of Sciences
2024
Sichuan Provincial Hospital of Traditional Chinese Medicine
2021-2024
University of Chinese Academy of Sciences
2024
Peking University
2016-2020
Peking University People's Hospital
2016-2020
Beijing Chest Hospital
2017-2018
Abstract The cure rate of osteosarcoma has not improved in the past 30 years. search for new treatments and drugs is urgently needed. Apatinib a high selectivity inhibitor vascular endothelial growth factor receptor-2 (VEGFR2) tyrosine kinase, exerting promising antitumoral effect various tumors. antitumor human never been reported. We investigated effects vitro vivo . Osteosarcoma patients with levels VEGFR2 have poor prognosis. can inhibit cell cells. In addition to cycle arrest apoptosis,...
Glioblastoma ( GBM ) is a highly aggressive brain tumor characterized by increased proliferation and resistance to chemotherapy radiotherapy. Recently, growing body of evidence suggests that glioma‐initiating cells GIC s) are responsible for the initiation recurrence . However, factors determining differential development s remain poorly defined. In present study, we show curcumin, natural compound with low toxicity in normal cells, significantly induced differentiation vivo vitro inducing...
Immune checkpoint inhibitors have led to a breakthrough in solid tumor immunotherapy, but related studies on musculoskeletal tumors are few, especially for PD-L2. We examined expression of three molecular effectors the PD-1 axis 234 patients with tumors, including osteosarcoma, chondrosarcoma, synovial sarcoma, and giant cell tumor. Survival analyses potential mechanisms were investigated osteosarcoma per Gene Expression Omnibus (GEO) immunohistochemistry analyses. In vivo, humanized mice...
Background Results of our previous study showed high objective response but short-term activity apatinib in advanced osteosarcoma. We aimed to investigate the combination with camrelizumab patients inoperable high-grade osteosarcoma progressing after chemotherapy. Methods This open-label, phase 2 trial was conducted at Peking University People’s Hospital. enrolled progressed Patients received 500 mg orally once daily plus 200 by intravenous infusion every weeks until disease progression or...
Abstract Current practices for the therapy of chondrosarcoma, including wide-margin surgical resection and chemotherapy, are less than satisfactory. Recently, emerging evidence has demonstrated that long non-coding RNAs (lncRNAs) have an essential role in initiation progression tumors. As a typical lncRNA, HOTAIR is significantly overexpressed various However, function potential biological mechanisms human chondrosarcoma remain unknown. Quantitative RT-PCR expression was upregulated tissues...
Abstract Background Recent studies indicated that exosomal programmed death-ligand 1 (PD-L1) derived from cancers could induce immunosuppression and tumor pathogenesis. However, it is unclear how exosomes influence osteosarcoma (OS) progression whether PD-L1 also exists in serum (Sr-exosomes) of patients with osteosarcoma. We examined 70 OS patients, 9 benign tumors 22 healthy donors. OS-derived were functionally evaluated vivo vitro. Results The characteristics patient cell lines confirmed...
Abstract Known as co-stimulatory molecule, programmed death ligand-2 (PD-L2) contributes to T-cell exhaustion by interaction with death-1 (PD-1) receptor, but its tumor cell-intrinsic signal effects have been little investigated. PD-L2 expression was detected immunohistochemistry in 18 pairs of primary osteosarcoma tissues and matching lung metastasis tissues. We also investigated the knockdown on both vitro vivo. In our study, elevated metastases compared according an assay. Wound-healing...
Endogenous O 2 can be continuously generated by the catalysis of Ce in lattice CeO to enhance 1 production via a type II PDT (energy transfer), and many other ROS (such as − ·OH) produced I (electron transfer).
Expression of COP9 signalosome subunit 3 (COPS3), an oncogene overexpressed in osteosarcoma, has been demonstrated to be significantly correlated with tumor metastasis. However, the underlying mechanism by which COPS3 promotes metastasis osteosarcoma and its role autophagy remain unknown. The expression was detected primary tissues matching lung immunohistochemistry (IHC). effect on cells investigated transwell, wound healing assays animal studies. Indicated proteins analyzed western...
Background: Osteosarcoma (OS) is the most prevailing primary bone tumour and third prevalent in children adolescents. Despite advanced treatments, survival rate of OS has not been effectively improved. Here, we intended to investigate functional impacts circ-ITCH on OS.Methods: Circ-ITCH expression tissues cells was evaluated utilizing qRT-PCR. Viability proliferation MG63 Saos-2 were determined by CCK-8 assay BrdU assay. Transwell utilized migration invasion. Western blot distinguish...
The cure rates for osteosarcoma have remained unchanged in the past three decades, especially patients with pulmonary metastasis. Thus, a new and effective treatment metastatic is urgently needed. Anlotinib has been reported to antitumor effects on advanced osteosarcoma. However, both effect of anlotinib autophagy mechanism anlotinib-mediated metastasis are unclear. was investigated by transwell assays, wound healing animal experiments. Related proteins were detected western blotting after...
In this study, we investigated Cas13a's efficacy in
Bone morphogenetic protein receptor 2 (BMPR2) has been identified in several types of cancer. However, its role osteosarcoma is largely unknown. We systematically investigated the BMPR2 cell lines, human tissue samples and xenograft models. The relationship between expression patients' survival was by bioinformatics clinical data. Wound healing assay transwell were used to detect changes migration invasion ability after transfection. In addition, downstream phosphoproteins analyzed...
The survival rate of osteosarcoma, the most prevalent primary bone tumor, has not been effectively improved in last 30 years. Hence, new treatments and drugs are urgently needed. Antiangiogenic therapy immunotherapy have good antitumor effects many kinds tumors. It is hypothesized that there may be a synergistic effect between immune checkpoint inhibitors antiangiogenic therapy. Nevertheless, its potential mechanism still unclear. Vascular endothelial growth factor receptor-2 (VEGFR2)...
Abstract The majority of patients with late-stage breast cancer develop distal bone metastases. microenvironment can affect response to therapy, and uncovering the underlying mechanisms could help identify improved strategies for treating metastatic cancer. Here, we observed that osteoclasts reduced sensitivity cells DNA damaging agents, including cisplatin PARP inhibitor (PARPi) olaparib. Metabolic profiling identified elevated glutamine production by osteoclasts. Glutamine supplementation...
In addition to treating acute promyelocytic leukemia, arsenic trioxide (ATO) suppresses other solid tumors, including chondrosarcoma. However, the effects of ATO on metastasis in chondrosarcoma cells, and underlying molecular mechanisms remain unclear. The migratory invasive capacities cells were investigated by Wound healing, Transwell EMT assays. expression miR-125b human tissues cell lines was detected real-time PCR analysis. Bisulfite sequencing analysis (BSP) used detect miR-125b....
Pulmonary metastasis is the main cause of poor prognosis in osteosarcoma. Sialic acid-bound immunoglobulin lectin 15 (Siglec-15) has been demonstrated to be obviously correlated with pulmonary osteosarcoma patients. However, effect Siglec-15 on autophagy remains unclear, while role and mechanism Siglec-15-related lung also remain unknown.The expression levels Beclin-1 were detected tissues using immunohistochemistry (IHC). The was investigated Transwell, wound healing animal experiments...