A5048999191- Multiple Myeloma Research and Treatments
- Protein Degradation and Inhibitors
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Extracellular vesicles in disease
- Ubiquitin and proteasome pathways
- Autophagy in Disease and Therapy
- Cell Adhesion Molecules Research
- MicroRNA in disease regulation
- Peptidase Inhibition and Analysis
- Epigenetics and DNA Methylation
- Cancer Mechanisms and Therapy
- Cancer-related gene regulation
- CNS Lymphoma Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Neurogenesis and neuroplasticity mechanisms
- Computational Drug Discovery Methods
- Lymphoma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Circular RNAs in diseases
- NF-κB Signaling Pathways
- Histone Deacetylase Inhibitors Research
- Bone Metabolism and Diseases
- Bone and Joint Diseases
Soochow University
2015-2025
Nanjing University
2025
Spintronics Research Network of Japan
2025
The University of Texas MD Anderson Cancer Center
2012
Suzhou University of Science and Technology
2010
Beihua University
2006
Multiple myeloma (MM) is characterized by the impaired osteogenic differentiation of mesenchymal stromal cells (MSCs). However, underlying molecular mechanisms are still poorly understood. Long noncoding RNAs (lncRNAs) emerging as important regulatory molecules in tumor-suppressor and oncogenic pathways. Here we showed that MSCs from MM expressed less lncRNA MEG3 relative to those normal donors during differentiation. To evaluate effect on osteogenesis, bone marrow with enhanced or reduced...
Glioblastoma ( GBM ) is a highly aggressive brain tumor characterized by increased proliferation and resistance to chemotherapy radiotherapy. Recently, growing body of evidence suggests that glioma‐initiating cells GIC s) are responsible for the initiation recurrence . However, factors determining differential development s remain poorly defined. In present study, we show curcumin, natural compound with low toxicity in normal cells, significantly induced differentiation vivo vitro inducing...
Glioblastoma (GBM) is a highly aggressive brain tumor characterized by increased proliferation and resistance to chemotherapy radiotherapy. Recently, the identification of tumor-initiating cells with stem-like properties in diverse human cancers including GBM represents an important conceptual advance cancer biology therapeutic implications. However, factors determining differential development radiosensitization glioma-initiating (GICs) remain poorly defined. Here, we report that rapamycin...
Abstract Purpose: How exosomal RNAs released within the bone marrow microenvironment affect proteasome inhibitors' (PI) sensitivity of multiple myeloma is currently unknown. This study aims to evaluate which are involved and by molecular mechanisms they exert this function. Experimental Design: Exosomes were characterized dynamic light scattering, transmission electron microscopy, Western blot analysis. Coculture experiments performed assess transferring from mesenchymal stem cells (MSC)...
The metagenomics sequencing data provide valuable resources for investigating the associa-tions between microbiome and host environmental/clinical factors dynamic changes of microbial abundance over time. distinct properties measurements include varied total sequence reads across samples, over-dispersion zero-inflation. Additionally, studies usually collect samples longitudinally, which introduces time-dependent correlation structures among thus further complicates analysis interpretation...
Diffuse large B-cell lymphoma (DLBCL) is characterized by its aggressive nature and resistance to standard chemotherapy, necessitating the development of new therapeutic approaches. The emergence natural products their derivatives has notably influenced cancer treatment, making morusinol, a medicine-derived monomer, promising candidate. Here, we showed that morusinol exerted antitumor effects on DLBCL in vitro inducing apoptosis cell cycle arrest. Impressively, treatment exhibited potent...
Chiral magnets have recently gained recognition as ideal hosts for topological spin textures, showing significant promise applications in next-generation spintronic devices. However, chiral are still scarce, and their transport properties been rarely explored. Here, a magnet, Cr1/3NbS2, has synthesized, its magnetic systematically investigated. A high magnetoresistance sensitivity of 52.5%/T is achieved, phase diagram helimagnetic (CHM), soliton lattice (CSL), forced ferromagnetic (FFM)...
High-dose methotrexate (HD-MTX) serves as the cornerstone of central nervous system lymphoma (CNSL) treatment, but its efficacy is limited due to low blood-brain barrier (BBB) penetration and adverse effects. This study focused on an exosome-based drug delivery approach aimed at enhancing BBB permeability, thereby reducing required dosage (MTX) while ensuring specific targeting CNSL. Human adipose-derived mesenchymal stem cells (hAMSCs) were modified with a lentiviral vector encoding...
Abstract The characteristics of mesenchymal stromal cells (MSCs) which derived from multiple myeloma (MM) patients are typically impaired in osteogenic differentiation. However, the underlying molecular mechanisms need to be further investigated. lncRNAs emerging as critical regulation molecules oncogenic pathways. In this study, we identified that bioactive lncRNA HOXC-AS3, is transcribed opposite HOXC10, was presented MSCs bone marrow (BM) MM (MM-MSCs). HOXC-AS3 able interact with HOXC10...
Exosomes have emerged as promising vehicles for delivering therapeutic cargoes to specific cells or tissues, owing their superior biocompatibility, reduced immunogenicity, and enhanced targeting capabilities compared with conventional drug delivery systems. In this study, we developed a platform using exosomes derived from monocytes, specifically designed targeted of bortezomib (Btz) multiple myeloma (MM) cells. Our approach involved the genetic modification monocytes express antibodies...
Large-scale molecular data have been increasingly used as an important resource for prognostic prediction of diseases and detection associated genes. However, standard approaches omics analysis ignore the group structure among genes encoded in functional relationships or pathway information.
Several studies demonstrate that the bromodomain inhibitor OTX015 has an antitumor activity in cancers. However, translation of these data to molecules suitable for clinical development yet be accomplished multiple myeloma (MM). Here, we identified genes and biologic processes substantiated antimyeloma with global transcriptomics. exerted a strong antiproliferative effect induced cell cycle arrest vitro. Gene expression profiling uncovered targeted NF-κB, EGFR, regulation, cancer...
Multiple myeloma (MM), like other cancers, is caused by the accumulation of genetic abnormalities. Heterogeneity exists in patients' response to treatments, for example, bortezomib. This urges efforts identify biomarkers from numerous molecular features and build predictive models identifying patients that can benefit a certain treatment scheme. However, previous studies treated multi-level ordinal drug as binary where only responsive non-responsive groups are considered.It desirable...