A5100350223- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Estrogen and related hormone effects
- Cancer-related gene regulation
- DNA Repair Mechanisms
- RNA Research and Splicing
- Histone Deacetylase Inhibitors Research
- Pluripotent Stem Cells Research
- MicroRNA in disease regulation
- Adipose Tissue and Metabolism
- Galectins and Cancer Biology
- CRISPR and Genetic Engineering
- Cancer-related Molecular Pathways
- Cancer, Hypoxia, and Metabolism
- Protease and Inhibitor Mechanisms
- Ubiquitin and proteasome pathways
- Lung Cancer Treatments and Mutations
- Adenosine and Purinergic Signaling
- Reproductive Biology and Fertility
- TGF-β signaling in diseases
- Virus-based gene therapy research
- NF-κB Signaling Pathways
- Cell Adhesion Molecules Research
- Circadian rhythm and melatonin
Beijing Forestry University
2022-2025
Nanjing University
2024-2025
Nanjing Drum Tower Hospital
2025
Hebei University of Chinese Medicine
2024-2025
First Hospital of Jilin University
2016-2024
Jilin University
2016-2024
Nanjing Medical University
2024
Second Affiliated Hospital of Nanjing Medical University
2024
The Fourth Affiliated Hospital of Soochow University (Suzhou Dushu Lake Hospital)
2024
Xuzhou Medical College
2019-2024
Abstract The advantage of oncolytic viruses (OV) in cancer therapy is their dual effect directly killing tumours while prompting anti-tumour immune response. Oncolytic parapoxvirus ovis (ORFV) and other OVs are thought to induce apoptosis, but being the immunogenically inert compared types cell death, does not explain highly inflamed microenvironment OV-challenged tumors. Here we show that ORFV its recombinant therapeutic derivatives able trigger tumor pyroptosis via Gasdermin E (GSDME)....
Tumor-associated macrophages (TAMs), most of which display the immunosuppressive M2 phenotype, affect tumor microenvironment and promote progression metastasis in lung carcinoma. In this study, we analyzed clinical non-small cell cancer (NSCLC) samples found that high densities TAMs were associated with a poor prognosis NSCLC patients. Moreover, number present correlated positively expression sex determining region Y (SRY)-related mobility group box 9 (SOX9) tissues. secreted TGF-β,...
Abstract Purpose: Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI), such as gefitinib and erlotinib, show favorable response to EGFR mutant lung cancer. However, the responders acquire resistance almost without exception. We recently reported that hepatocyte (HGF) induces EGFR-TKI by activating MET restores downstream mitogen activated protein (MAPK)/extracellular signal regulated (ERK)1/2 phosphoinositide 3-kinase (PI3K)/Akt signaling. The purpose of this study was...
The human genome, like other mammalian genomes, encodes numerous natural antisense transcripts (NATs) that have been classified into head-to-head, tail-to-tail, or fully overlapped categories in reference to their sense transcripts. Evidence for NAT-mediated epigenetic silencing of transcription remains scanty. DHRS4 gene a metabolic enzyme and forms cluster with its two immediately downstream homologous genes, DHRS4L2 DHRS4L1, generated by duplication. We identified head-to-head NAT DHRS4,...
Long non-coding RNAs (lncRNAs) play crucial roles in diverse biological processes and have drawn extensive attention the past few years. However, lncRNAs remain poorly understood about expression Crassostrea gigas, a potential model organism for marine molluscan studies. Here, we systematically identified mantles of C. gigas from four full-sib families characterized by white, black, golden, partially pigmented shell. Using poly(A)-independent strand-specific RNA-seq, total 441,205,852 clean...
Coronary artery disease (CAD) is the most common type of cardiovascular and becomes a leading cause death worldwide. Aiming to uncover underlying molecular features for different types CAD, we classified 352 CAD cases into three subgroups based on gene expression profiles, which were retrieved from Gene Expression Omnibus database. Also, these present patterns clinical characteristics. To transcriptomic differences between subgroups, weighted co-expression analysis (WGCNA) was used...
The transcriptional changes around zygotic genome activation (ZGA) in preimplantation embryos are critical for studying mechanisms of embryonic developmental arrest and searching key transcription factors. However, studies on the profile porcine ZGA limited.In this study, we performed RNA sequencing vivo developed (IVV) somatic cell nuclear transfer (SCNT) embryo at different stages compared activity with mouse, bovine human embryos. results showed that transcriptome map early was...
Abstract Asperosaponin VI (ASA VI), a natural compound isolated from the well-known traditional Chinese herb Radix Dipsaci , has an important role in promoting osteoblast formation. However, its effects on osteoblasts context of osteoporosis is unknown. This study aimed to investigate and mechanism ASA action proliferation osteogenic differentiation bone marrow stromal cells ovariectomized rats (OVX rBMSCs). The toxicity OVX rBMSCs were measured using CCK-8 assay. Various markers also...
Abstract An increasing amount of evidence suggests that long intergenic noncoding RNAs (lincRNAs) may play diverse roles in many cellular processes. However, little is known about lincRNAs marine invertebrates. Here, we presented the first identification and characterization Pacific oyster ( Crassostrea gigas ). We developed a pipeline identified 11,668 C. based on RNA-Seq resources available. These exhibited common characteristics with vertebrate lincRNAs: relatively short length, low exon...
Increasing evidence indicates the occurrence of cognitive impairment in astronauts under spaceflight compound conditions, but underlying mechanisms and countermeasures need to be explored. In this study, we found that learning memory abilities were significantly reduced rats a simulated long-duration environment (SLSE), which includes microgravity, isolation confinement, noises, altered circadian rhythms. Dammarane sapogenins (DS), alkaline hydrolyzed products ginsenosides, can enhance...
Microglia are key regulators of the inflammatory response in brain. Adenosine RNAs can be converted to m6A (N6-methyladenosine), which regulates RNA metabolism and functions as a epitranscriptomic modification. The modification pattern m6A-related signatures under pro-inflammatory anti-inflammatory conditions microglia remain unclear.Primary rat were differentiated into M1-like (M1-L), M2-like (M2-L), resting, unstimulated (M0-L) phenotypes. mRNA lncRNA microarray analyses performed, pathway...
Abstract An unstable epigenome is implicated in the pathophysiology of neurodevelopmental disorders such as schizophrenia and autism. This important because potentially modifiable. We have previously reported that adult offspring exposed to maternal immune activation (MIA) prenatally significant global DNA hypomethylation hypothalamus. However, what genes had altered methylation state, their functional effects on gene expression whether these changes can be moderated, not been addressed. In...
Acute kidney injury (AKI) is a common organ in sepsis, which leads to poor prognosis. Long noncoding RNA (lncRNA) small nucleolus host gene 14 (SNHG14) was recognized induce cell LPS-induced acute lung and Parkinson’s disease. We want investigate the functions mechanisms of SNHG14 sepsis-induced AKI. Increased expression observed HK-2 cells, this due activation TLR4/NF-κB pathway. In vitro studies showed that involved oxidative stress, inflammation, apoptosis cells. Further investigations...
Abstract Glutamate dehydrogenase 1 (GLUD1) is implicated in oncogenesis. However, little known about the relationship between GLUD1 and hepatocellular carcinoma (HCC). In present study, we demonstrated that expression levels of significantly decreased tumors, which was relevant to poor prognosis HCC. Functionally, silencing enhanced growth migration HCC cells. Mechanistically, upregulation interleukin-32 through AKT activation contributes silencing-facilitated hepatocarcinogenesis. The...
Dysregulated epithelial-mesenchymal transition (EMT) is involved in cervical cancer metastasis and associated with histone acetylation. However, the underlying molecular mechanisms of acetylation EMT are still elusive.We systematically investigated expression patterns genes their correlations pathway cancer. The CSRP2BP among tissues cell lines was detected using Western blotting immunohistochemistry analyses. effects on proliferation tumorigenicity were examined by growth curve, EdU assay,...
Laccases (LACs), belonging to the multicopper oxidase family, are closely associated with various biological functions including lignin synthesis and responses biotic abiotic stresses in plants. However, few studies have reported laccase genes China rose (Rosa chinensis). Prickles cause difficulties management harvest of R. chinensis become a trait concerned breeding. To investigate expression patterns roses, we cloned gene from an ancient variety 'Old Blush' named it RcLAC15. The level...
Terpenes are pivotal for plant growth, development, and adaptation to environmental stresses. With the advent of extensive genomic data sophisticated bioinformatics tools, new insights into evolutionary dynamics functional diversification terpene synthases (TPSs) have emerged. Despite genome-wide identifications TPS family in certain species, comprehensive cross-species analyses remain scarce. In this study, we conducted a identification subgroup classification families across 115...