A5100747556- Ion Transport and Channel Regulation
- Mycotoxins in Agriculture and Food
- Adenosine and Purinergic Signaling
- Immunotherapy and Immune Responses
- Neuroscience and Neuropharmacology Research
- Neurogenesis and neuroplasticity mechanisms
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Phosphodiesterase function and regulation
- Evaluation and Optimization Models
- Magnesium in Health and Disease
- Bamboo properties and applications
- Nuts composition and effects
- RNA Research and Splicing
- Fermentation and Sensory Analysis
- Vagus Nerve Stimulation Research
- Developmental Biology and Gene Regulation
- Insect Utilization and Effects
- Peripheral Neuropathies and Disorders
- Advanced Cellulose Research Studies
- Marine Biology and Environmental Chemistry
- Food Quality and Safety Studies
- RNA regulation and disease
- Heart Failure Treatment and Management
- Advanced Glycation End Products research
- International Business and FDI
Guiyang Medical University
2020-2025
Zhejiang A & F University
2023
Guangdong Food Industry Research Institute
2023
The Affiliated Yongchuan Hospital of Chongqing Medical University
2022
Chongqing Medical University
2022
Shanghai University of Traditional Chinese Medicine
2018-2021
Wuhan University
2021
Renmin Hospital of Wuhan University
2021
Peking Union Medical College Hospital
2018-2020
Chinese Academy of Medical Sciences & Peking Union Medical College
2018-2020
Coronary artery disease (CAD) is the most common type of cardiovascular and becomes a leading cause death worldwide. Aiming to uncover underlying molecular features for different types CAD, we classified 352 CAD cases into three subgroups based on gene expression profiles, which were retrieved from Gene Expression Omnibus database. Also, these present patterns clinical characteristics. To transcriptomic differences between subgroups, weighted co-expression analysis (WGCNA) was used...
The zinc finger transcription factor Zeb1 binds to E-box-like sequences and is important for maintaining repression of epithelial specification genes in vivo. Overexpression cancer triggers epithelial-mesenchymal transition, which facilitates metastasis. mutation ZEB1 humans linked posterior polymorphous corneal dystrophy (PPCD), an transition the endothelium associated with abnormal endothelial proliferation. purpose this study determine whether null or heterozygous mice may provide animal...
Leaf vascular system differentiation and venation pattern plays a key role in transporting nutrients keeping the plant shape, which is an important agronomic trait for improving photosynthetic efficiency. However, knowledge about regulation of leaf specification development little. Here we utilized rice midribless mutant (dl2) to investigate molecular changes transcriptome proteome profilings during differentiation. Using isobaric tag relative absolute quantification (iTRAQ) digital gene...
Exposure to Aflatoxin B1 (AFB1) is considered a significant risk factor for human diseases, including the immune function impairment of cells. Dendritic cells (DCs), as essential antigen-presenting cells, play pivotal role in bridging innate and adaptive immunity. However, impact AFB1 exposure on DCs has not been fully elucidated. In this study, we investigated effects migration ability its underlying action model. Initially, observed that inhibited survival altered their cellular...
Fumonisin B1 (FB1) is one of the most toxic mycotoxins and harmful to humans animals due its hepatotoxicity, immunotoxicity carcinogenicity. However, mechanism immunosuppressive effect still under investigation. Dendritic cells (DCs) are potent professional antigen-presenting cells, their differentiation, maturation immunomodulatory functions closely related certain mycotoxins. Migratory capacity a prerequisite for mature DCs (mDCs) move present antigens in secondary lymphoid tissue, whereas...
Summary Response surface methodology was used to optimise pectin recovery from sugar beet pulp using ultrasound‐/microwave‐assisted acid method ( UMAAM ). The independent variables were microwave heating temperature, time and solid‐to‐liquid ratio. From the results, selected optimal conditions 92 °C, 37 min, ratio 1:30. Under these conditions, yield uronic content of SBP 1) 26.16% 75.38%, respectively. Compared with 2) extracted by traditional method, 1 showed a higher molecular weight,...
In the production process of puree cans such as chestnuts cans, it is easy to browning due excessive heating, which causes a lot waste every year. The heat and mass transfer model Chinese Chestnut Puree was established through finite element method. simulated change temperature field, flow velocity field F value during Puree. After comparing confirming effectiveness thermal penetration test, used adjust optimize process. For #9121 two-stage sterilization method adopted. Through at...
Acyl carrier protein (ACP) is an acyl in fatty acid synthesis and important cofactor of synthetase. Little known about ACP insects how this may modulate the composition storage acids. We used RNAi-assisted strategy to study potential function Hermetia illucens (Diptera: Stratiomyidae). identified a HiACP gene with cDNA length 501 bp classical conserved region DSLD. This was highly expressed egg late larval instars most abundant midgut fat bodies larvae. Injection dsACP significantly...
Objective: The main objective of this study is to evaluate the effects integrated Chinese and Western medicine in treatment neurological autoimmune diseases. Materials Methods: literature was comprehensively searched collect randomized controlled trials about Neurological diseases mainly occur central nervous system (CNS) peripheral system. Therefore, multiple sclerosis (MS) chosen as representative CNS, Guillain–Barre syndrome (GBS) Extended Disability Status Scale (EDSS) score, effective...
Emotional memory deficit is a well-known complication in early Parkinson's disease. However, its molecular mechanism still not well known. To address this issue, we examined the cue-related fear-conditioning task and long-term potentiation (LTP) of thalamus to lateral amygdala rats treated with low doses reserpine (Res). We found that low-dose Res treatment impaired emotional LTP. also exogenous upregulation norepinephrine (NE) ameliorated impairment LTP by facilitating β-adrenergic...
Objectives: Hypertension is one of the most important complications diabetic nephropathy. In our previous study, we found adenosine type 1 receptor (A1AR) played a significant role in progress But whether A1AR was involved regulation blood pressure remain unknown. this try to explore effect on nephropathy and its possible mechanism. Methods: Type mice model established by intraperitoneal injection streptozotocin wide knock-out for 4 weeks. Systolic detected tail artery monitor, urine kidney...
Objectives: A critical role for thiazide-sensitive sodium-chloride co-transporter (NCC) in the regulation of renal sodium homeostasis and blood pressure has been proposed. Mutations SLC12A3 gene encoding NCC cause Gitelman syndrome (GS), an inherited salt-losing tubulopathy. As a good model to understand pathophysiological mechanism salt-sensitive hypertension, GS attracted more attentions. In this study, we explored phenotypic features different genders, pregnant issue it. Methods: cases at...
Abstract Background and Aims Hypocalciuria is considered typical in Gitelman syndrome (GS). However, a few GS cases diagnosed by gene testing presented as normocalciuria have been reported recent years. Our study to observe the clinical features patients with different urinary calcium excretions, investigate value of excretion classification for GS. Method from National Rare Diseases Registry System China (NRSC) (2016-2018) SLCl2A3 screened Peking Union Medical College Hospital were...