A5103139631- Neuroinflammation and Neurodegeneration Mechanisms
- Immune cells in cancer
- Cancer Immunotherapy and Biomarkers
- Peripheral Neuropathies and Disorders
- Pharmacological Effects of Natural Compounds
- Cancer Cells and Metastasis
- Immune Response and Inflammation
- Gut microbiota and health
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Multiple Sclerosis Research Studies
- Neurogenesis and neuroplasticity mechanisms
- Barrier Structure and Function Studies
- MicroRNA in disease regulation
- Gastrointestinal motility and disorders
- Long-Term Effects of COVID-19
- Genomics, phytochemicals, and oxidative stress
- Reproductive System and Pregnancy
- Vector-Borne Animal Diseases
- Plant-based Medicinal Research
- Melanoma and MAPK Pathways
- Peripheral Nerve Disorders
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Vitamin C and Antioxidants Research
- Axon Guidance and Neuronal Signaling
Yueyang Hospital
2018-2024
Shanghai University of Traditional Chinese Medicine
2018-2024
South China Agricultural University
2023
Key Laboratory of Guangdong Province
2023
First Affiliated Hospital of Heilongjiang University of Chinese Medicine
2006
Abstract Astragalus polysaccharides (APS), the main effective component of membranaceus , can inhibit tumor growth, but underlying mechanisms remain unclear. Previous studies have suggested that APS regulate gut microenvironment, including microbiota and fecal metabolites. In this work, our results showed could control growth in melanoma‐bearing mice. It reduce number myeloid‐derived suppressor cells (MDSC), as well expression MDSC‐related molecule Arg‐1 cytokines IL‐10 TGF‐β, so CD8 + T...
Activated microglia is considered to be major mediators of the neuroinflammatory environment in demyelinating diseases central nervous system (CNS). are mainly polarized into M1 type, which plays a role promoting inflammation and demyelinating. However, proportion M2 type relatively low, cannot fully play anti-inflammatory resistance Our previous study found that Astragalus polysaccharides (APS) has an immunomodulatory effect can inhibit neuroinflammation demyelination experimental...
Melanoma is a highly aggressive form of skin cancer. The existence cancer stem cells (CSCs) and tumor immune evasion are two major causes melanoma progression, but no effective treatment has been found at present. Astragalus polysaccharide (APS) principal active component derived from membranaceus, showing anti-tumor effects in various tumors including melanoma. However, the underlying mechanism still unclear. regulation APS on self-renewal ability CSC markers expression (MSCs) was measured...
Abstract Objective: Qu Du Qiang Fei 1 Hao Fang (QDQF1) is a novel Chinese herbal medicine formula used to treat coronavirus disease 2019 (COVID-19). However, the pharmacological mechanisms of action QDQF1 remain unclear. The objective this study was identify effective ingredients and biological targets for COVID-19 treatment. Materials Methods: were analyzed by using network pharmacology methods, which included an analysis corresponding targets, COVID-19-related target acquisition,...
Recently, there has been an increased focus on cancer stem cells (CSCs) due to their resilience, making them difficult eradicate. This resilience often leads tumor recurrence and metastasis. CSCs adeptly manipulate surroundings create environment conducive survival. In this environment, myeloid-derived suppressor (MDSCs) play a crucial role in promoting epithelial–mesenchymal transition bolstering CSCs' stemness. response, attract MDSCs, enhancing infiltration, expansion immunosuppressive...
Pathogenic CD8+T cells play an essential role in neuroinflammation and neural injury, which leads to the progression of inflammatory neurological disorders. Thus, blocking infiltration is necessary for treatment neuroinflammatory diseases. Our previous study demonstrated that astragalus polysaccharide (APS) could significantly reduce experimental autoimmune encephalomyelitis mice. However, mechanism by APS suppresses cell remains elusive. In this study, we further found lipopolysaccharide...
Pseudorabies virus (PRV) is considered to be a promising oncolytic that has potential as cancer gene therapy drug. In this study, PRV-DCD-1-70 was used vector carry exogenous genes IL-18, IFN-γ and PH20 construct novel recombinant PRV, rPRV-PH20 rPRV-IL-18-γ-PH20, their tumorolytic effects were evaluated in vitro vivo. Our study showed PRV lysed all four tumor cell lines, Pan02, EMT-6, CT26 H446, rPRV-IL-18-γ-PH20 the best lysis effect. Further studies mice bearing Pan02 tumors especially...
Objective: The main objective of this study is to evaluate the effects integrated Chinese and Western medicine in treatment neurological autoimmune diseases. Materials Methods: literature was comprehensively searched collect randomized controlled trials about Neurological diseases mainly occur central nervous system (CNS) peripheral system. Therefore, multiple sclerosis (MS) chosen as representative CNS, Guillain–Barre syndrome (GBS) Extended Disability Status Scale (EDSS) score, effective...
Objective: The objective of the study is to evaluate therapeutic efficacy integrative medicine in treatment immunological disorders nervous system. Methods: Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines were adopted conduct this study, which included randomized controlled trials with a confirmed diagnosis multiple sclerosis (MS), myasthenia gravis (MG), Guillain–Barre syndrome (GBS), all treated medicine. effective rate, recurrent frequency, disease score used...
To investigate the effect of Fuyu Decoction on ventricular remodeling and its association with AMPK/mTOR pathway-mediated autophagy in rats heart failure.Thirty male Wistar rat models failure induced by ligation left anterior descending coronary artery were divided into model group, treatment +AMPK agonist group (n=10), another 10 receiving sham operation as Sham group. After 8 weeks drug intervention, changes function indexs assessed. TTC staining was used to detect myocardial infarction...
Abstract The Th17/Treg imbalance is an important cause of immune cell infiltration into the central nervous system (CNS) and subsequent neuroinflammation, demyelination, neurodegeneration in multiple sclerosis (MS). Increasing attention has been given to role microbiota-gut-brain axis MS pathogenesis. gut microbiota affects balance as well distal areas, such CNS, which further contributes onset progression MS. Our previous studies have shown that Astragalus polysaccharide (APS) a alleviating...