A5033818633- Spaceflight effects on biology
- Herpesvirus Infections and Treatments
- High Altitude and Hypoxia
- Cytomegalovirus and herpesvirus research
- Medical and Biological Ozone Research
- Traditional Chinese Medicine Studies
- Virus-based gene therapy research
- Gut microbiota and health
- Lipid metabolism and disorders
- Circular RNAs in diseases
- Muscle metabolism and nutrition
- Stress Responses and Cortisol
- Adipose Tissue and Metabolism
- Vestibular and auditory disorders
- Cervical Cancer and HPV Research
- Anesthesia and Neurotoxicity Research
- Mitochondrial Function and Pathology
- Cancer-related molecular mechanisms research
- Dermatologic Treatments and Research
- Spine and Intervertebral Disc Pathology
- Biochemical effects in animals
- Medicinal Plants and Bioactive Compounds
- Dermatology and Skin Diseases
- Acupuncture Treatment Research Studies
- Cervical and Thoracic Myelopathy
Huanggang Central Hospital
2025
China Three Gorges University
2025
China Astronaut Research and Training Center
2014-2024
Institute of Psychology, Chinese Academy of Sciences
2024
University of Chinese Academy of Sciences
2014-2024
Beijing Hospital of Traditional Chinese Medicine
2020-2024
Capital Medical University
2020-2024
Tsinghua University
2023
State Key Laboratory of Space Medicine Fundamentals and Application
2014-2022
Yuhuangding Hospital
2022
Increasing evidence indicates the occurrence of cognitive impairment in astronauts under spaceflight compound conditions, but underlying mechanisms and countermeasures need to be explored. In this study, we found that learning memory abilities were significantly reduced rats a simulated long-duration environment (SLSE), which includes microgravity, isolation confinement, noises, altered circadian rhythms. Dammarane sapogenins (DS), alkaline hydrolyzed products ginsenosides, can enhance...
Objective: To compare the efficacy of intense pulsed light (IPL) (540–950nm) in treating different erythema associated with rosacea. Methods: Thirty-two patients erythematotelangiectatic rosacea (ETR) (n = 16) and papulopustular (PPR, n were recruited. Three treatments IPL administered on face at 3-week intervals. Clinical improvement was independently assessed by two dermatologists using a quartile grading scale [0, ≤ 25% (poor); 1, 26–50% (fair); 2, 51–75% (good); 3, 76–100% (excellent)]....
Herpes zoster (HZ) is caused by the varicella-zoster virus (VZV), and 20% of healthy humans 50% people with immune dysfunction have a high probability suffering from HZ. This study aimed to screen dynamic signatures explore potential mechanism during HZ progression.Peripheral blood samples 31 patients 32 age-sex-matched controls were collected analyzed. The protein levels gene toll-like receptors (TLRs) detected in peripheral mononuclear cells (PBMCs) flow cytometry quantitative real-time...
Adolescent athletes participating in sports involving sudden directional changes, pivoting, and jumping frequently sustain anterior cruciate ligament (ACL) ruptures. ACL reconstruction (ACLR) surgery is often required, followed by a lengthy rehabilitation period. This study aims to evaluate the effectiveness of combining BOth Sides Up (BOSU) ball exercises with conventional resistance training recovery joint stability function after ACLR adolescent athletes. Thirty (ages 14–18) who underwent...
Abstract Introduction Long‐term spaceflight composite stress (LSCS) can cause adverse effects on human systems, including the central nervous system, which could trigger anxiety and depression. Aims This study aimed to identify changes in hippocampus synaptic plasticity under LSCS. Methods The present simulated real long‐term space station environment by conducting a 42‐day experiment that involved simulating microgravity, isolation, noise, circadian rhythm disruptions, low pressure. mood...
Methicillin-resistant Staphylococcus aureus (MRSA) is a worldwide health threat and has already tormented humanity during its long history, creating an urgent need for the development of new classes antibacterial agents. In this study, twenty-one novel sulfonylurea derivatives containing phenyl-5-vinyl pyrimidinyl-4-aryl moieties were designed synthesized, among which, nine compounds exhibited inhibitory potencies against Gram-positive bacterial strains: MRSA (Chaoyang clinical isolates), S....
Candida albicans is an opportunistic pathogenic yeast, which could become in various stressful environmental factors including the spaceflight environment. In this study, we aim to explore phenotypic changes and possible mechanisms of C. after exposure conditions.The effect carried on "SJ-10" satellite for 12 days was evaluated by proliferation, morphology, resistance virulence experiment. The result showed that proliferation rate, biofilm formation, antioxidant capacity, cytotoxicity...
Confined experiments are carried out to simulate the closed environment of space capsule on ground. The Chinese Controlled Ecological Life Support System (CELSS) is designed including a closed-loop system supporting 4 healthy volunteers surviving for 180 days, and we aim reveal temporal characteristics oropharyngeal nasal microbiota structure in crewmembers stayed days CELSS, so as accumulate information about balance associated with respiratory health estimating risk future spaceflight. We...
Background and Objectives Alopecia areata (AA) is an autoimmune disease characterized by T cell‐mediated attack on the hair follicle. Although there are a wide range of therapies, majority them not satisfactory due to side effects or limited efficacy. In this study, we sought evaluate efficacy, influence factors, safety 308‐nm excimer lamp with minoxidil in treatment AA. Study Design/Materials Methods This was prospective, single‐blinded, self‐control using for One selected alopecia lesion...
Mars500 study was a psychological and physiological isolation experiment conducted by Russia, the European Space Agency, China, in preparation for an unspecified future manned spaceflight to planet Mars. Its intention yield valuable medical data on effects of planned long-term deep space mission. In this paper, we present mining methods mine collected from crew consisting six spaceman volunteers. The synthesis four diagnostic TCM, inspection, listening, inquiry, palpation, is used our...
As the representatives of closely related Chinese medicinal materials (CMMs) originated from Rutaceae family, Aurantii fructus immaturus (AFI), (AF), Citri reticulatae pericarpium viride (CRPV), and (CRP) have better functions in regulating qi promoting gastrointestinal motility. However, differences quality Citrus CMMs not yet been revealed until now. Herein, this study focused on systematic differentiation in-depth understanding by a strategy integrating chemometrics network pharmacology....
Isochronal function projective synchronization between chaotic and time-delayed systems with unknown parameters is investigated in this article. Based on Lyapunov stability theory, adaptive controllers parameter updating laws are designed to achieve the isochronal systems. The scheme applied realize Lorenz hyper-chaotic Chen systems, respectively. Numerical simulations also presented show effectiveness of proposed method. Mathematics Subject Classification 2000: 34C28; 34D20; 37N35.