A5030464145- Chemical Synthesis and Analysis
- Crystallization and Solubility Studies
- Synthesis and biological activity
- X-ray Diffraction in Crystallography
- Click Chemistry and Applications
- Monoclonal and Polyclonal Antibodies Research
- Fungal Plant Pathogen Control
- Synthesis and Biological Evaluation
- Insect Pest Control Strategies
- Genomics, phytochemicals, and oxidative stress
- Ferrocene Chemistry and Applications
- Biochemical and Structural Characterization
- Weed Control and Herbicide Applications
- Synthesis and Characterization of Heterocyclic Compounds
- Pesticide and Herbicide Environmental Studies
- Radiopharmaceutical Chemistry and Applications
- Organoselenium and organotellurium chemistry
- Phenothiazines and Benzothiazines Synthesis and Activities
- Organic and Inorganic Chemical Reactions
Australian National University
2024
Nankai University
2022-2023
Abstract Genetically encoded libraries play a crucial role in discovering structurally rigid, high-affinity macrocyclic peptide ligands for therapeutic applications. Bicyclic peptides with metal centres like bismuth were recently developed as new type of constrained notable affinity, stability and membrane permeability. This study represents the genetic encoding peptide-bismuth peptide-arsenic bicycles phage display. We introduce tripotassium dicitrate (gastrodenol) water-soluble...
Methicillin-resistant Staphylococcus aureus (MRSA) is a worldwide health threat and has already tormented humanity during its long history, creating an urgent need for the development of new classes antibacterial agents. In this study, twenty-one novel sulfonylurea derivatives containing phenyl-5-vinyl pyrimidinyl-4-aryl moieties were designed synthesized, among which, nine compounds exhibited inhibitory potencies against Gram-positive bacterial strains: MRSA (Chaoyang clinical isolates), S....
Peptide therapeutics play an increasingly important role in modern drug discovery. Improving the pharmacokinetic profile of bioactive peptides has been effectively achieved with chemical modifications, especially macrocyclisation reactions. Consequently, there is a great demand for highly constrained compounds such as bicyclic peptides. In our previous research, we introduced peptide–bismuth bicycles and peptide–arsenic new classes this work, extend peptide bicyclisation strategy towards...
In order to design compounds with fresh molecular skeleton break through the limitation of available agrochemicals, a series 36 novel selenenyl sulfide were chemically synthesized, and their biological activities fully evaluated against tobacco mosaic virus (TMV), 14 plant pathogenic fungi, three insect species acetohydroxyacid synthase (AHAS).All target characterized by proton nuclear magnetic resonance (1 H-NMR), carbon-13 (13 C)-NMR, selenium-77 (77 Se)-NMR, high-resolution mass...
Abstract Genetically encoded libraries play a crucial role in discovering structurally rigid, high-affinity macrocyclic peptide ligands for therapeutic applications. This study represents the first genetic encoding of peptide-bismuth and peptide-arsenic bicyclic peptides phage display. We introduce bismuth tripotassium dicitrate (gastrodenol) as water-soluble Bi(III) reagent library modification situ preparation, eliminating need organic co-solvents. Additionally, we explore As(III) an...
Abstract A series of 51 novel sulfonylurea compounds with ortho ‐alkoxy substituent at phenyl ring were chemically synthesized and spectroscopically characterized. The biological activities the target evaluated using enzyme inhibition against acetohydroxyacid synthase (AHAS; EC 2.2.1.6) from fungal or plant source, as well cell‐based antifungal assay greenhouse pot herbicidal assay. Among compounds, 6e showed desirable activity Candida albicans standard isolate sc5314 minimum concentration...
Chiral α-amino nitriles, derived from their canonical acids, can be attached to the peptide C-terminus and undergo biocompatible cyclisation with an N-terminal cysteine residue, yielding macrocyclic thiazole peptides after mild oxidation.