A5062682530- Eosinophilic Disorders and Syndromes
- Immune Cell Function and Interaction
- Eosinophilic Esophagitis
- T-cell and B-cell Immunology
- Cancer Immunotherapy and Biomarkers
- SARS-CoV-2 and COVID-19 Research
- MXene and MAX Phase Materials
- Immune Response and Inflammation
- Immune cells in cancer
- RNA modifications and cancer
- COVID-19 Clinical Research Studies
- Cytokine Signaling Pathways and Interactions
- FOXO transcription factor regulation
- Liver Disease Diagnosis and Treatment
- Immunodeficiency and Autoimmune Disorders
- Advanced Photocatalysis Techniques
- Pancreatic and Hepatic Oncology Research
- CRISPR and Genetic Engineering
- Heat shock proteins research
- Graphene and Nanomaterials Applications
- Carbon and Quantum Dots Applications
- 2D Materials and Applications
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Biomarkers in Disease Mechanisms
- Food Allergy and Anaphylaxis Research
Northwestern University
2022-2024
Qingdao University
2022-2024
First Affiliated Hospital of Xiamen University
2024
Zhengzhou University
2019-2023
University of Duisburg-Essen
2022-2023
Peking University
2023
Peking University Cancer Hospital
2023
Second Military Medical University
2012-2022
Changhai Hospital
2012-2022
Jinan University
2017
Somatic hypermutation (SHM) and class-switch recombination (CSR) of Ig genes are dependent upon activation-induced cytidine deaminase (AID)-induced mutations. The scaffolding properties proliferating cell nuclear antigen (PCNA) ubiquitylation its residue K164 have been suggested to play an important role organizing the error-prone repair events that contribute AID-induced diversification locus. We generated knockout mice for PCNA ( Pcna −/− ), which were embryonic lethal. Expression with...
Endogenous O 2 can be continuously generated by the catalysis of Ce in lattice CeO to enhance 1 production via a type II PDT (energy transfer), and many other ROS (such as − ·OH) produced I (electron transfer).
The metastasis of colorectal cancer frequently tends to liver, which is one the three leading causes cancer-related deaths worldwide. Growing evidence showed that aspirin could effectively inhibit liver cancer. However, potential mechanism has not been fully understood. Mouse splenic vein assay was used examine metastatic ability colon cells in vivo. And wound healing and transwell were applied detect C26 HCT116 cell lines vitro. RT-PCR western blotting explore Toll-like receptor 4 (TLR4)...
Class switch recombination (CSR) involves a DNA rearrangement in the Ig heavy chain (IgH) gene that allows same variable (V) region to be expressed with any one of downstream constant (C) genes encode antibodies many different effector functions. One hypothesis for how CSR is targeted C histone modifications increase accessibility and/or recruit activation-induced cytosine deaminase (AID) and its associated processes particular donor recipient regions. In this work, we identified H3 acetyl...
Hypoxia is one of the inherent characteristics most solid tumors; oxygen-dependent (O2) nature photodynamic therapy (PDT) limits its clinical treatment against hypoxia tumors. Therefore, improving oxygen partial pressure hypoxic tumors great significance to improve PDT effect. Herein, we synthesized Ti3C2@Porphyridium nanobiohybrids (MX@Pr) by electrostatic self-assembly photosynthetic oxygen-producing Porphyridium (Pr) and photosensitizer two-dimensional Ti3C2 (MX). Upon 660 nm laser...
Biomimetic bi-metal polydopamine nanospheres (FeCo@PDA NPs) with strong adhesion and catalytic Fenton reactive enzyme activity can significantly kill Escherichia coli ( E. ) Staphylococcus aureus S. by destroyed the bacterial membrane structure produce ROS.
The resistance to EGF receptor (EGFR) tyrosine kinase inhibitors (TKI) is a major challenge in the treatment of non-small cell lung cancer (NSCLC). Understanding molecular mechanisms behind therefore an important issue. Here we assessed role EGFR pathway substrate 8 (EPS8) and Forkhead box O 3a (FoxO3a) as potentially valuable targets NSCLC .The expression levels EPS8 FoxO3a patients with (n = 75) were examined by immunohistochemistry staining, while cells detected qPCR western blot. effects...
The tumor microenvironment (TME) is comprised of cells, infiltrating immune and stroma. Multiple reports suggest that the cell infiltration (ICI) in TME strongly associated with responsiveness to immunotherapy prognosis certain cancers. Thus far, ICI profile pancreatic carcinoma (PC) remains unclear. Here, we employed two algorithms characterize PC patients. Based on our results, identified 2 patterns calculated score by using principal component analysis. Furthermore, revealed patients low...
Colorectal cancer is one of the most commonly diagnosed types and a leading cause cancer‑associated mortality worldwide. Short chain enoyl coenzyme A hydratase 1 (ECHS1) an important gene involved in mitochondrial fatty acid β‑oxidation pathway. In addition, ECHS1 has been implicated variety cancers, including breast, prostate, colon liver cancer. The aim present study was to examine expression human HCT‑8 colorectal cell line. results showed that significantly increased...
Abstract Pancreatic ductal carcinoma (PDAC) is a malignant tumor of the digestive tract characterized by gradual onset, rapid progression and poor prognosis. VISTA newly discovered immune checkpoint belonging to B7 family PD-1 PD-L1. In this study, expression in tissues was significantly higher than that para-cancer tissues. It may also be associated with PDAC’s immunosuppressive microenvironment. Furthermore, best prognosis involved pancreatic cancer patients high alongside more uniform CT...