A5101209485- Hydraulic Fracturing and Reservoir Analysis
- Hydrocarbon exploration and reservoir analysis
- Enhanced Oil Recovery Techniques
- MicroRNA in disease regulation
- Immune Response and Inflammation
- Cancer-related molecular mechanisms research
- Inflammatory mediators and NSAID effects
- Drilling and Well Engineering
- Methane Hydrates and Related Phenomena
- Cancer Genomics and Diagnostics
- Nanoplatforms for cancer theranostics
- RNA modifications and cancer
- NF-κB Signaling Pathways
- Advanced Nanomaterials in Catalysis
- Human Pose and Action Recognition
- Video Surveillance and Tracking Methods
- Nanoparticle-Based Drug Delivery
- Pancreatic and Hepatic Oncology Research
- Epigenetics and DNA Methylation
- Gastric Cancer Management and Outcomes
- Helicobacter pylori-related gastroenterology studies
- Ferroptosis and cancer prognosis
- Genetic factors in colorectal cancer
- Cancer, Stress, Anesthesia, and Immune Response
- Water Treatment and Disinfection
China University of Geosciences (Beijing)
2021-2025
Second Military Medical University
2012-2024
National University of Singapore
2024
Beijing Jiaotong University
2024
Hefei Institutes of Physical Science
2023
Chinese Academy of Sciences
2023
Anhui University
2023
Institute of Solid State Physics
2023
Hefei National Center for Physical Sciences at Nanoscale
2023
University of Science and Technology of China
2023
Conformable and wireless charging energy storage devices play important roles in enabling the fast development of wearable, non-contact soft electronics. However, current power sources are still restricted by limited flexural angles fragile connection components, resulting failure expression performance constraining their further applications health monitoring wearables moveable artificial limbs. Herein, we present an ultracompatible skin-like integrated micro-supercapacitor, which building...
The object of the study is to identify N-glycan profiling changes associated with gastric cancer and explore impact core-fucosylation on biological behaviors human cells. A total 244 subjects including cancer, ulcer healthy control were recruited. from serum proteins in tissues was analyzed by DNA sequencer-assisted fluorophore-assisted capillary electrophoresis. abundance core-fucosylated residues expression enzymes involved lectin blot, quantitative reverse transcription-polymerase chain...
The metastasis of colorectal cancer frequently tends to liver, which is one the three leading causes cancer-related deaths worldwide. Growing evidence showed that aspirin could effectively inhibit liver cancer. However, potential mechanism has not been fully understood. Mouse splenic vein assay was used examine metastatic ability colon cells in vivo. And wound healing and transwell were applied detect C26 HCT116 cell lines vitro. RT-PCR western blotting explore Toll-like receptor 4 (TLR4)...
Microbiologically influenced corrosion (MIC) is a universal issue of significant concern in the petroleum industry, with potential for enormous economic losses and casualties. This study focused on effect temperature MIC mechanism. The rate, morphology, products, microbial community composition produced fluid samples from Zhanjiang oilfield were measured after anaerobic culture at 30 60 °C 14 days. rate Z1 Z2 decreased increasing temperature, while Z3 sample changed light to heavy corrosion....
Abstract: In recent years, gold nanoclusters have been widely used in catalysis, and alloying has become one of the most important methods for improving catalytic performance nanoclusters. terms electrocatalytic reduction CO2 (CO2RR), although many show fairly good Faraday efficiencies through Cd-doping, they still exhibit low current density. Furthermore, as an increasing number Au-Cd alloy are reported, there is a growing interest understanding correlation between Cd coordination catalysis...
Abstract Background Chemotherapy resistance is an important bottleneck affecting the efficacy of chemotherapy in colon cancer. Therefore, improving sensitivity colorectal cancer cells great significance for prognosis patients with Methods CCK-8 assay was employed to examine cell viability lines. Realtime-PCR and western blot were used explore toll-like receptor 4 (TLR4) expression The functions TLR4 stemness lines analyzed by infecting lentivirus containing siRNA. Results We found that...
The intensive development of tight reservoirs has positioned them as a strategic alternative to conventional oil and gas resources. Existing enhanced recovery (EOR) methods struggle effectively exploring reservoir oil, resulting in low rates. Novel effective means developing are urgently needed. Nanomaterials have shown promising applications improving water flooding efficiency, with in-depth research into mechanisms that lower injection pressure increase volumes. However, the extent...
Colorectal cancer (CRC) has a rising morbidity worldwide and its resistance to chemotherapy been observed in clinical treatment. Tumor suppressor p53 is well-studied CRC, but little known about effects during DNA damage of CRC cells. This study was aimed at uncovering potential mechanisms regarding microRNA-374b v-akt murine thymoma viral oncogene homolog 1 (AKT1) cells HCT116 HT29 were transfected with p53-specific small interfering RNA (siRNA), overexpression vector or miR-374b inhibitor,...
PPRV infection induces cellular autophagy; however, the intracellular responses and signaling mechanisms that occur upon are obscure, whether innate immune linked with autophagy to regulate viral replication is largely unknown. Here, we uncovered sensor MDA5 initiated cascade by upregulating STING, which best known for its role in anti-DNA virus inducing interferon expression.
Sonochemotherapy (SCT) has emerged as a powerful modality for cancer treatment by triggering excessive production of reactive oxygen species (ROS) and controlled release chemotherapeutic agents under ultrasound. However, achieving spatiotemporally during ROS generation is still an enormous challenge. In this work, we developed cascade-activated nanoprodrug (CAN) system that utilizes reversible covalent Schiff base mixed with hypoxia-activatable camptothecin (CPT) prodrug. Briefly, the...
With high clay content in shale gas reservoir, the hydration is easy during hydraulic fracturing, which will affect fracture conductivity and productivity of wells. The illite Longmaxi formation Yongchuan District (more than 80% mineral content), wells have a after fracturing shut-in. However, effect mechanism fluid on rich not clear. Therefore, this paper, core experiments are performed for reservoir. water imbibition characteristic near-fracture obtained, micro-morphology microfracture...
Gastric cancer (GC) is a heterogeneous disease, and leading cause of deaths in Eastern Asia. Genomic analysis, such as whole-exome sequencing (WES), can help identify key genetic alterations to the malignancy diversity GC, may new drug targets.We identified genomic cohort 38 GC patients, including 26 metastatic 12 non-metastatic patients. We analyzed association between novel gene mutations copy number variations (CNVs) with tumor metastasis patient survival.A significantly mutated genes...
Immune checkpoint inhibitors (ICIs) improve overall survival in patients with advanced gastric cancer (GC). However, the molecular characterization of GC ICIs responders is unclear. A total 288 were included this study. Next-generation sequencing analysis was performed on tumor tissue and paired blood to screen for somatic mutants 639 tumor-associated genes. We demonstrated that ARID1A, HER2/3/4, KMT2C/2D, LRP1B, PIK3CA, SPTA1, TP53 mutations significantly correlated high mutation burden...
It is worldwide accepted that lncRNA PTCSC3 a tumor suppressor in glioma and thyroid cancer, whereas its role the recurrence of gastric cancer unknown.We recruited 80 GC patients (46 males 34 females, 44 to 68 years, 56.3±6.7 years) our study. Two human cell lines AGS SNU-1 were transfected with HOXA11-AS expression vectors. Then, qPCR was used detect level relative mRNA. Both invasion migration assays performed effect on motility.In present study, we showed downregulated plasma than healthy...
What is the optimal neoadjuvant chemotherapy (NAC) regimen for locally advanced gastric cancer (LAGC) remains debatable. The objective of this study was to compare efficacy docetaxel+oxaliplatin+S-1 (DOS) vs oxaliplatin+S-1 (SOX) as NAC LAGC.Data 248 LAGC patients who received either DOS or SOX in our hospital between January 2010 and 2018 were reviewed retrospectively. Propensity score matched (PSM) analysis applied minimize selection bias both groups. Prognostic factors screened by...
Altered expression of family with sequence similarity 84, member B (FAM84B) has been found in various human cancers.However, the and function FAM84B pancreatic ductal adenocarcinoma (PDAC) not studied.Here, by analyzing The Cancer Genome Atlas cohort, we that amplification was observed 11% 141 PDAC patients, correlated higher mRNA FAM84B.FAM84B overexpression significantly poor overall survival.Moreover, knockdown cell lines suppressed proliferation induced apoptosis.FAM84B also...
Abstract Although it has been known that protein synthesis is suppressed in sepsis, which cannot be corrected by leucine supplement (also as resistance), the molecular signaling mechanism remains unclear. This study aimed to investigate AMP‐activated kinase/mammalian target of rapamycin (AMPK/mTOR) pathway sepsis‐induced resistance and its upstream signals, seek a way correct sepsis. Sepsis was produced cecal ligation puncture (CLP) model rat. Both septic rats sham operation rat received...
Low field pulse nuclear magnetic resonance (LF-NMR) was used to analyze the effects of a polymeric ion retarder and amount acryloxyethyl trimethylammonium chloride (DMC) in on distribution T2, thickening property, strength cement paste. The effect pressure temperature curve investigated, hydration products were analyzed using XRD. result shows that wrapped water precipitation is main reaction aqueous phase slurry hydration, with short T2 time large relaxation peak area. weakens van der Waals...