A5100614779- Reproductive Biology and Fertility
- Viral Infections and Vectors
- Mosquito-borne diseases and control
- Autophagy in Disease and Therapy
- Ovarian function and disorders
- Medical Research and Treatments
- interferon and immune responses
- Assisted Reproductive Technology and Twin Pregnancy
- Environmental and Agricultural Sciences
- Toxoplasma gondii Research Studies
- Cardiac Health and Mental Health
- Endometriosis Research and Treatment
- Transcranial Magnetic Stimulation Studies
- Neonatal and Maternal Infections
- Neural and Behavioral Psychology Studies
- Adipose Tissue and Metabolism
- Prenatal Screening and Diagnostics
- Virus-based gene therapy research
- Immune Response and Inflammation
- Medicinal Plant Pharmacodynamics Research
- Fluoride Effects and Removal
- Spinal Dysraphism and Malformations
- Sirtuins and Resveratrol in Medicine
- Kruppel-like factors research
- Forest, Soil, and Plant Ecology in China
Southwest Minzu University
2021-2024
Zhengzhou Central Hospital
2023
First Affiliated Hospital of Hebei Medical University
2017-2023
Hebei Medical University
2017-2023
Capital Medical University
2023
Weifang People's Hospital
2022
Handan College
2022
Henan University Huaihe Hospital and Huaihe Clinical Institute
2021
Lanzhou Veterinary Research Institute
2017-2020
Liaocheng People's Hospital
2020
A large body of evidence suggests that repetitive transcranial magnetic stimulation (rTMS) is clinically effective in treating neuropsychiatric disorders and multiple sessions are commonly used. However, it unknown whether rTMS improve cognitive control, which a function the neural circuitry left dorsolateral prefrontal cortex (DLPFC)-cingulate healthy individuals. In addition, still unclear stages processing altered by rTMS. this study, we investigated effects high-frequency on control...
While the functions of STING1 (stimulator interferon response cGAMP interactor 1) during DNA virus infection had been well documented, roles plays RNA viruses is obscure. Infection with foot-and-mouth disease (FMDV), a well-known picornavirus, induces endoplasmic reticulum (ER) stress and autophagy. Here, we found that FMDV-induced integrated originates from cellular pattern recognition receptor DDX58/RIG-I (DExD/H-box helicase 58). DDX58 transmits signals to ER-anchored adaptor protein...
Premature ovarian insufficiency (POI) refers to the decline and cessation of functions in women under 40 years age. Melatonin (MT) acts as a protective for ovary. This study elucidated role MT autophagy granulosa cells (GCs) POI via modulating phosphatidylinositol-3-kinase (PI3K)-Akt-mammalian target rapamycin (mTOR) pathway.The expression levels microRNA (miR)-15a-5p, signal transducer activator transcription 3 (Stat3), relevant hormones clinically collected serum samples patients healthy...
Canine distemper virus (CDV) is one of the most contagious and lethal viruses known to Canidae, with a very broad expanding host range. Autophagy serves as fundamental stabilizing response against pathogens, but some have been able evade or exploit it for their replication. However, effect autophagy mechanisms on CDV infection still unclear.In present study, was induced in CDV-infected Vero cells demonstrated by elevated LC3-II levels aggregation green fluorescent protein (GFP)-LC3 spots....
PPRV infection induces cellular autophagy; however, the intracellular responses and signaling mechanisms that occur upon are obscure, whether innate immune linked with autophagy to regulate viral replication is largely unknown. Here, we uncovered sensor MDA5 initiated cascade by upregulating STING, which best known for its role in anti-DNA virus inducing interferon expression.
Endometriosis is a common reproductive disorder in women, with global prevalence of 10‑15%. Long noncoding RNAs (lncRNAs) are critical to gene transcription, cell cycle modulation and immune response. The lncRNA metastasis‑associated lung adenocarcinoma transcript 1 (MALAT1) reportedly mediates autophagy endometrial stromal cells endometriosis. present study aimed evaluate the role mechanism MALAT1 granulosa (GCs) Consequently, expression was upregulated GCs obtained from patients...
This study sought to further verify the protective mechanism of Melatonin (MT) against ovarian damage through animal model experiments and lay a theoretical experimental foundation for exploring new approaches treatment.The wet weight index rat ovaries were weighted, morphology tissues number follicles in pathological sections collected recorded. And serum sex hormone levels, key proteins autophagy pathway (PI3K, AKT, mTOR, LC3II, LC3I, Agt5) tissues, as well viability mortality granulosa...
Sirtuins (SIRT1-SIRT7) are a family of NAD+-dependent protein deacetylases that linked to post-translational regulation many metabolic processes. There few reports available for chicken sirtuins (designated cSIRT1-cSIRT7), whose expression and in the liver have yet be explored. In present study, we characterized sirtuin members liver. The results showed share same conserved functional SIR2 domains. All were expressed extensively all tissues examined, levels cSIRT1, cSIRT2, cSIRT4, cSIRT6,...
Unlike the effect of repetitive transcranial magnetic stimulation (rTMS) in treating neuropsychiatric diseases, little is known about how personal factors might account for disparity results from studies cognition and rTMS. In this study, we investigated effects high-frequency rTMS on response inhibition control explored time course changes cognitive processing brain metabolic mechanisms after using event-related potentials (ERPs) resonance spectroscopy (1H-MRS).Participants were all...
Peste des petits ruminants virus (PPRV) is a morbillivirus that causes the acute and highly pathogenic infectious disease peste (PPR) in small poses major threat to goat sheep industries. Currently, there no effective treatment for PPRV infection. Here, we propose Carboplatin, platinum-based regimen designed treat range of malignancies, as potential antiviral agent. We showed Carboplatin exhibits significant activity against cell culture model. The mechanism action mainly attributed its...
The objective of the present study was to observe curative effect and mechanism melatonin for suppression premature ovarian failure (POF). From December 2014 June 2015, 128 patients were consecutively diagnosed with POF in Department Gynaecology Obstetrics. randomly divided into experimental control groups. group received tablets (1-3 mg/day), while placebo tablets. levels six sex hormones, percentage T lymphocytes G1/M phase, reactive oxygen species (ROS) determined at four different...
Seneca Valley Virus (SVV), a member of the Picornaviridae family, is an emerging porcine virus that can cause vesicular disease in pigs. However, immune evasion mechanism SVV remains unclear, as does its interaction with other pathways. STING (Stimulator interferon genes) typically recognized critical factor innate responses to DNA infection, but role during infection poorly understood. In present study, we observed was degraded SVV-infected PK-15 cells, and replication cells affected when...
To explore the diagnosis value of inflammatory markers and cytokines in neonatal sepsis.
Multilocular cystic renal cell carcinoma (MCRCC) is an uncommon low-grade with unique morphologic features. The 2004 World Health Organization classification of kidney tumors categorized MCRCC as a separate entity. authors report the case 48-year-old man whose originated from lower portion duplex (DK). Because oncological outcome favorable, regardless tumor size and stage, patients might benefit nephron-sparing surgery. It important to distinguish larger MCRCCs other carcinomas, especially...
Background Immunoglobulin D (IgD) multiple myeloma (MM) is a rare subtype of MM and commonly occurs in younger subjects but at later stage the International Staging System (ISS) when admitted. As special type IgD myeloma, IgD-λ/λ biclonal rarer. Its serum protein electrophoresis immuno-fixation (IFE) might find no anomalies even if bone marrow (BM) examination performed. Thus, it easy to miss diagnosis. Case summary A 62-year-old man diagnosed as (ISS III) was admitted with fatigue weight...