A5071763744- MicroRNA in disease regulation
- T-cell and B-cell Immunology
- Cancer-related molecular mechanisms research
- Virology and Viral Diseases
- Immune Cell Function and Interaction
- RNA Research and Splicing
- Circular RNAs in diseases
- DNA Repair Mechanisms
- Gut microbiota and health
- Plant Molecular Biology Research
- Genetic factors in colorectal cancer
- Traumatic Brain Injury Research
- Immunotherapy and Immune Responses
- Viral Infections and Vectors
- Herpesvirus Infections and Treatments
- Trace Elements in Health
- Cancer Genomics and Diagnostics
- Epigenetics and DNA Methylation
- Traumatic Brain Injury and Neurovascular Disturbances
- Cervical Cancer and HPV Research
- Biochemical effects in animals
- Air Quality and Health Impacts
- Plant Micronutrient Interactions and Effects
- Plant Stress Responses and Tolerance
- Neurological Disease Mechanisms and Treatments
Kunming Medical University
2015-2025
Anhui Science and Technology University
2019-2025
Anhui University of Science and Technology
2019-2025
Harbin Institute of Technology
2025
Shanghai Aerospace Automobile Electromechanical (China)
2024
Ministry of Agriculture and Rural Affairs
2024
Jiangsu Academy of Agricultural Sciences
2019-2024
Hebei Medical University
2010-2023
Weatherford College
2022
China Agricultural University
2011-2021
Despite several factors influencing reproduction in geese, but the precise molecular mechanisms of egg cessation are not fully understood. In present study, hematopoietic parameters and serum hormone levels Wanxi white geese were analyzed. RNA-Seq was utilized to identify differentially expressed mRNAs (DEGs) lncRNAs (DE lncRNAs) ovarian tissues associated with nesting during late-laying periods. Triglyceride (TG) alkaline phosphatase (ALP) higher while blood cell (WBC), neutrophil (NEU),...
Somatic hypermutation (SHM) and class-switch recombination (CSR) of Ig genes are dependent upon activation-induced cytidine deaminase (AID)-induced mutations. The scaffolding properties proliferating cell nuclear antigen (PCNA) ubiquitylation its residue K164 have been suggested to play an important role organizing the error-prone repair events that contribute AID-induced diversification locus. We generated knockout mice for PCNA ( Pcna −/− ), which were embryonic lethal. Expression with...
Boron is an essential trace element with roles in growth, development, and physiological functions; however, its mechanism of action still unclear. In this study, the regulatory PI3K/Akt signaling pathway on boron-induced changes barrier function, proliferation, apoptosis rat intestinal epithelial cells were evaluated. Occludin levels, proportion G2/M phase, cell proliferation rate, mRNA protein expression levels PCNA higher, while proportions G0/G1 S phases, caspase-3 lower treated 0.8...
Introduction Enterotoxigenic Escherichia coli (ETEC) is the main diarrhea-causing pathogen in children and young animals has become a global health concern. Berberine type of “medicine food homology” long history use China, particularly treating gastrointestinal disorders bacterial diarrhea. Methods In this study, we explored effects berberine on growth performance, intestinal inflammation, oxidative damage, microbiota weaned piglet model ETEC infection. Twenty-four piglets were randomly...
Background: Recent years, there occurs heavy haze pollution in northern China during wintertime. The potential influence of airborne particulate matter (PM) on human health attracts great concern. fuel-derived PM the inhalable size range is dominated by aggregates nanoparticles Carbon black (CB). However, are still lack evidences especially regarding long-term exposure to explain chronic effects nanoscaled CB and relative mechanism. Purpose: objective this study was identify mechanism...
Introduction Enterotoxic Escherichia coli (ETEC) is the main pathogen that causes diarrhea, especially in young children. This disease can lead to substantial morbidity and mortality a major global health concern. Managing ETEC infections challenging owing increasing prevalence of antibiotic resistance. Berberine, categorized as substance with similarities “medicine food,” has been used China for hundreds years treat gastrointestinal disorders bacteria-induced diarrhea. study investigated...
Background Studies have shown that more than half of the human genome expression is affected by circadian rhythms, which includes genes involved in cell cycle control, DNA repair and apoptosis are critical cancer biology. However, roles rhythm-related (CRRGs) cervical (CC) other common gynecologic cancers remain unclear. Methods The transcriptome data clinical information related to CC were extracted from UCSC Xena Gene Expression Omnibus (GEO) databases. In this study, differentially...
<title>Abstract</title> We examine whether higher eco-efficiency encourages local governments to co-produce environmental solutions with citizens. Using Chinese provincial data and advanced textual analysis, we find that high strongly predicts more collaborative responses complaints. Causal inference suggests crossing a threshold of increases co-production probabilities by about 24 percentage points, indicating eco-efficiency’s potential as catalyst for participatory governance.
In our study, we explored changes in the redox status and inflammatory response testes of SAMP8 model varying ages (2, 4, 8, 10 months old) compared with control mice SAMR1 by methods immunohistochemical staining, Western blotting, RT-PCR Luminex multi-analyte cytokine profiling. We found that as ROS inflammation levels increased during aging, steroidogenic enzymes (StAR P450scc) reduced led to decline testosterone production eventually. The pathways P38 MAPK → COX2 NF-κB were detected using...
This study aimed to investigate the effects of bile acids (BAs) supplementation on fatty liver hemorrhagic syndrome (FLHS), production performance, and physiological quality characteristics laying hen eggs. Sixty Sanhuang hens, aged 28 weeks, were randomly allocated six dietary treatments over a 4-week period, including control (CON) group (feeding basal diet), high-fat diet (HFD)-treated (basal containing 10% soybean oil), HFD supplemented with 0.01% 0.02% chenodeoxycholic acid (CDCA) or...
Abstract This report describes the genetic characterization of 297 wild-type measles viruses that were isolated in 24 provinces China between 1995 and 2003. Phylogenetic analysis N gene sequences showed all isolates belonged to genotype H1 except 3 isolates, which A. The nucleotide sequence predicted amino acid homologies 294-genotype strains 94.7%–100% 93.3%–100%, respectively. divided into 2 clusters, differed by approximately 2.9% at level. Viruses from both clusters distributed...
The incidence of rubella cases in China from 1991 to 2007 was reviewed, and the nucleotide sequences 123 viruses collected during 1999 4 viral previously reported 1979 1984 were phylogenetically analyzed. Rubella vaccination not included national immunization programs before 2007. Changes endemic compared with incidences epidemics. results showed that epidemics occur approximately every 6 8 years (1993/1994, 2001, 2007), a shift disease burden susceptible young adults observed. Chinese virus...
Mismatch repair of AID-generated dU:G mispairs is critical for class switch recombination (CSR) and somatic hypermutation (SHM) in B cells. The generation a previously unavailable Msh2(-/-)Msh6(-/-) mouse has the first time allowed us to examine impact complete loss MutSalpha on lymphomagenesis, CSR SHM. onset T cell lymphomas survival Msh2(-/-)Msh6(-/-)Msh3(-/-) mice are indistinguishable from Msh2(-/-) mice, suggesting that MSH2 plays role protecting cells malignant transformation,...
Antibody diversification through somatic hypermutation (SHM) and class switch recombination (CSR) are similarly initiated in B cells with the generation of U:G mismatches by activation-induced cytidine deaminase but differ their subsequent mutagenic consequences. Although SHM relies on nondeleterious point mutations, CSR depends production DNA double-strand breaks (DSBs) adequate nonhomologous end joining (NHEJ). MLH1, an ATPase member mismatch repair (MMR) machinery, is emerging as a likely...
Marek's disease (MD), caused by virus (MDV), is a lymphoproliferative neoplastic of chickens and characterized MD lymphoma in multiple visceral organs chicken. It causes great damage to poultry health. Recently, miRNA has been reported be involved lymphomagenesis. Our previous study showed that gga-miR-181a was downregulated MDV-induced lymphoma, its target gene, v-myb myeloblastosis viral oncogene homolog-like 1 (MYBL1), predicted. In this study, the interaction between MYBL1 further...
Marek's disease (MD), caused by virus (MDV), is a lymphotropic neoplastic disease. Previous miRNAome analysis showed gga-miR-219b was significantly downregulated in MDV-induced lymphoma, and one of its potential target genes, B-cell chronic lymphocytic /lymphoma 11B (BCL11B) predicted. In this study, we further investigated the function gga-miR-219b, gain/loss assay inhibited cell migration reduced proliferation promoting apoptosis not cycle arrest. Gga-miR-219b also suppressed expression...
Abstract Cachexia is the dramatic weight loss and muscle atrophy seen in chronic disease states, including autoimmunity, cancer, infection, often associated with lymphopenia. We have previously shown that CD4+ T cells express lowest density of CD44 (CD4+CD44v.low) are significantly reduced diabetic NOD mice cachexic compared not cachexic. Using this model, a model cancer cachexia, we test hypothesis CD4+CD44v.low play an active role protecting host from cachexia. cells, but depleted...
Mechanisms that control the size of T cell pool, ratio between naive cells and memory cells, number frequency regulatory receptor (TCR) diversity are necessary to maintain immune integrity avoid disease. We have previously shown a subset CD4+ defined by expression on their surface very low density CD44 (CD44v.low cells), can inhibit wasting wasting-associated lymphopenia in mice with cancer. In this study, we further investigate properties CD44v.low show they significantly more efficient...
Marek's disease (MD) is a highly contagious viral neoplastic caused by virus (MDV), which can lead to huge economic losses in the poultry industry. Recently, microRNAs (miRNAs) have been found various cancers and tumors. In recent years, 994 mature miRNAs identified through deep sequencing chickens, but only few investigated further terms of their function. Previously, gga-miR-103-3p was downregulated MDV-infected samples using Solexa sequencing. this study, we verified expression among...
Rubella remains a significant burden in mainland China. In this report, 667 viruses collected 24 of 31 provinces China during 2010-2012 were sequenced and analyzed, significantly extending previous reports on limited numbers before 2010. Only genotypes 1E 2B found. Genotype found all provinces. likely introduced into around 1997 endemic transmission primarily one lineage became established. Viruses reported here from are largely single cluster within lineage. rarely detected prior to This...