A5025361466- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Traditional Chinese Medicine Studies
- MicroRNA in disease regulation
- Metabolomics and Mass Spectrometry Studies
- Bioinformatics and Genomic Networks
- Cancer-related molecular mechanisms research
- Hepatitis C virus research
- Cancer-related Molecular Pathways
- Liver physiology and pathology
- Pharmacological Effects of Natural Compounds
- Curcumin's Biomedical Applications
- Ferroptosis and cancer prognosis
- Cancer Cells and Metastasis
- Ginseng Biological Effects and Applications
- Circular RNAs in diseases
- Identification and Quantification in Food
- Cancer Mechanisms and Therapy
- Drug-Induced Hepatotoxicity and Protection
- Retinoids in leukemia and cellular processes
- Traditional Chinese Medicine Analysis
- Flavonoids in Medical Research
- Synthesis and biological activity
- Viral Infections and Vectors
- RNA Interference and Gene Delivery
Shanghai University of Traditional Chinese Medicine
2014-2024
Zhejiang Center for Disease Control and Prevention
2010-2019
Shanghai University
2013-2017
Vanderbilt University Medical Center
2010
Shanghai Public Health Clinical Center
2010
Jiangnan University
2008
Metastasis is a major cause of death in patients with breast cancer. In the process cancer development, epithelial-mesenchymal transition (EMT) crucial to promoting invasion and migration tumor cells. previous study, role resveratrol metastasis was investigated MDA-MB-231 (MDA231) human cells xenograft-bearing mouse model. Additionally, related mechanism explored. present vitro Transwell assays showed that can inhibit transforming growth factor (TGF)-β1-induced MDA231 concentration-dependent...
Cancer cells with stem cell-like properties contribute to the development of resistance chemotherapy and eventually tumor relapses. The current study investigated potential curcumin reduce breast cancer cell (BCSC) population for sensitizing mitomycin C (MMC) both in vitro vivo. Curcumin improved sensitivity paclitaxel, cisplatin, doxorubicin lines MCF-7 MDA-MB-231, as shown by more than 2-fold decrease half-maximal inhibitory concentration these chemotherapeutic agents. In addition,...
// Liu Yang 1 , Dongdong Fang Huijun Chen 2 Yiyu Lu Zheng Dong 3 Han-Fei Ding 4 Qing Jing 5 Shi-Bing Su 1,6 and Shuang Huang 1,6,7 Research Center for Traditional Chinese Medicine Complexity System, Shanghai University of Medicine, Shanghai, China Department Obstetrics Gynecology, Zhongnan Hospital Wuhan University, Wuhan, Hubei Province, Anatomy Cell Biology, Medical College Georgia, Georgia Regents Augusta, GA, USA Cancer Center, Cardiology, Changhai Hospital, 6 E-institute Municipal...
Curcumin, a natural compound derived from the turmeric rhizome Curcuma longa Linn, has anticancer and chemoresistance reduction biological activities. We evaluated efficacy of curcumin in sensitizing chemotherapy drugs through regulation Bcl-2-mediated apoptosis breast cancer stem-like cells (BCSCs). Cell survival was measured using MTT assay. Apoptosis-related proteins were observed western blot analysis. Apoptosis detected with flow cytometric analysis by Hoechst 33258 staining. The...
Triple-negative breast cancer (TNBC) is a refractory type of that does not yet have clinically effective drugs. The aim this study to investigate the synergistic effects and mechanisms resveratrol combined with cisplatin on human MDA-MB-231 (MDA231) cell viability, migration, invasion in vivo vitro. In vitro, MTS assays showed inhibits viability as concentration-dependent manner, produced (CI < 1). Transwell assay treatment TGF-β1-induced migration invasion. Immunofluorescence confirmed...
Background/Aim: The synergistic combinations of natural products have long been the basis Traditional Chinese herbal Medicine formulas. In this study, we investigated effects a combination berberine and evodiamine against human breast cancer MCF-7 cells in vitro vivo, explored its mechanism. Materials Methods: Cell survival was measured using MTT assay. Apoptosis-related proteins were observed western blot analysis. Apoptosis detected with flow cytometric analysis by Hoechst 33258 staining....
Background: Collagen-related cell adhesion molecules (CAMs) are a major component of the extracellular matrix (ECM) and often accumulate in liver during chronic disease or hepatocellular carcinoma (HCC). In this study we identified several promising collagens related to CAMs that may be clinical use for diagnosis prognosis HCC. Methods: We obtained multi-omics data including RNA sequencing (RNA-Seq) data, microarray proteomic from TCGA, GEO databases, GTEx, NODE. Bioinformatics analyses were...
Hepatitis B virus (HBV) infection is an important factor causing hepatocellular carcinoma (HCC). The aim of this study was to investigate the metabolic characteristics and related enzyme changes during progression from chronic hepatitis (CHB) liver cirrhosis (LC) and, ultimately, HCC. An untargeted metabolomics assay performed in plasma 50 healthy volunteers, 43 CHB patients, 67 LC 39 HCC patients. A total 24 differential metabolites (DMs) were identified. Joint pathway analysis suggested...
Aim . To evaluate and predict the therapeutic efficacy of Fuzheng-Huayu tablet (FZHY) based traditional Chinese Medicine (TCM) syndrome differentiation or TCM symptoms on chronic hepatitis B caused cirrhosis (HBC). Methods. The trial was designed according to CONSORT statement. It a multi-center, double-blind, randomized, placebo-controlled trail. Several clinical parameters, Child-Pugh classification were detected evaluated. FZHY predicted by an established Bayes forecasting method...
Traditional Chinese medicine (TCM) treatment is based on the traditional diagnose method to distinguish TCM syndrome, not disease. So there a phenomenon in relationship between syndrome and disease, called Same Syndrome for Different Diseases Disease. In this study, we demonstrated molecular mechanisms of using microarray samples liver-gallbladder dampness-heat (LGDHS) liver depression spleen deficiency (LDSDS) chronic hepatitis B (CHB) cirrhosis (LC). The results showed that difference CHB...
// Hui Zhang 1 , Xiu-Li Yan 2 Xin-Xin Guo Miao-Juan Shi Yi-Yu Lu Qian-Mei Zhou Qi-Long Chen Yi-Yang Hu 3 Lie-Ming Xu Shuang Huang 1, 4 and Shi-Bing Su Research Center for Traditional Chinese Medicine Complexity System, Shanghai University of Medicine, Pudong, 201203, China Yueyang Hospital Integrated Western Hongkou, 200437, Shuguang Hospital, Department Anatomy Cell Biology, Florida College Gainesville, FL, USA Correspondence to: Su, email: shibingsu07@163.com Keywords: MiR-27a; predictor;...
Xiaoyaosan decoction (XYS), a classical Traditional Chinese Medicine (TCM) formula is used to treat liver fibrosis in clinics.This study explores defined compound combinations from XYS fibrosis.Network pharmacology combined with transcriptomics analysis was analyze the and depression spleen deficiency syndrome fibrosis. From constructed XYS-Syndrome-liver network, top 10 active formulas were developed by topological according network stability. The most determined vitro study. anti-fibrosis...
Huangqi decoction (HQD) is used for liver fibrosis and cirrhosis treatment in Chinese medicine. This study aims to investigate the pharmacological actions of HQD against rats by high-throughput gene expression profiling, network analysis real-time qRT-PCR.We analyzed profiles differentially expressed genes (DEGs) dimethylnitrosamine (DMN)-induced rat. The tissue samples control group (n = 3), model 3) were examined microarrays. Pathways KEGG. Pathway-gene protein-protein interaction (PPI)...
In traditional Chinese medicine (TCM) clinical practice, TCM syndromes help to understand human homeostasis and guide individualized treatment. However, the syndrome changes with disease progression, of which scientific basis mechanism remain unclear.To demonstrate underlying dynamic in syndrome, we applied a network biomarker (DNB) algorithm obtain DNBs based on transcriptomic data patients chronic hepatitis B typical syndromes, including healthy controls liver-gallbladder dampness-heat...