A5078197216- Nanoplatforms for cancer theranostics
- Radiopharmaceutical Chemistry and Applications
- interferon and immune responses
- Medical Imaging Techniques and Applications
- Cancer Immunotherapy and Biomarkers
- Cancer, Hypoxia, and Metabolism
- Traditional Chinese Medicine Studies
- Pharmacological Effects of Natural Compounds
- MicroRNA in disease regulation
- Cancer, Stress, Anesthesia, and Immune Response
- Ginseng Biological Effects and Applications
- Cancer-related Molecular Pathways
- Inflammasome and immune disorders
- Acupuncture Treatment Research Studies
- Cancer-related molecular mechanisms research
- Cancer Mechanisms and Therapy
- Peptidase Inhibition and Analysis
- Cardiac Imaging and Diagnostics
- Liver physiology and pathology
- Radiomics and Machine Learning in Medical Imaging
- Thyroid Cancer Diagnosis and Treatment
- Metabolomics and Mass Spectrometry Studies
- Drug-Induced Hepatotoxicity and Protection
- Liver Disease Diagnosis and Treatment
- Bioactive Compounds and Antitumor Agents
Shanghai Tenth People's Hospital
2020-2024
Tongji University
2020-2024
Nanjing Agricultural University
2022-2024
Ministry of Agriculture and Rural Affairs
2024
Xihua University
2023
Shanghai University of Traditional Chinese Medicine
2018-2021
University of Electronic Science and Technology of China
2021
Zhejiang Chinese Medical University
2020
Guangdong Pharmaceutical University
2016-2018
Yinchenhao decoction (YCHD) is a classical Traditional Chinese Medicine (TCM) formula that has been widely used in the treatment of liver fibrosis caused by chronic hepatitis B and jaundice for more than 1800 years. The purpose this study was to investigate apoptosis regulation mechanisms YCHD its active components suppresses fibrosis. putative targets were predicted network pharmacology approach. Functional pathway enrichment analysis presented present using clusterProfiler. Further,...
Triple-negative breast cancer (TNBC) is a refractory type of that does not yet have clinically effective drugs. The aim this study to investigate the synergistic effects and mechanisms resveratrol combined with cisplatin on human MDA-MB-231 (MDA231) cell viability, migration, invasion in vivo vitro. In vitro, MTS assays showed inhibits viability as concentration-dependent manner, produced (CI < 1). Transwell assay treatment TGF-β1-induced migration invasion. Immunofluorescence confirmed...
Similar to other local therapeutic methods, interstitial radiotherapy (IRT) also suffers from insufficient systematic immune activation, resulting in tumor metastasis.Mn-based IRT radiosensitizers consisting of 131I, MnO2 and bovine serum albumin (BSA) (131I-MnO2-BSA) were engineered. Such Mn-based successfully unlocked radiogenetics magnify responses via remodeling hypoxic immunosuppressive microenvironments resist metastasis. The 131I-MnO2-BSA caused decomposition H2O2 enriched tumors...
Astatine-211 is an α-emitter with high-energy α-ray and high cytotoxicity for cancer cells. However, the targeted alpha therapy (TAT) also suffers from insufficient systematic immune activation, resulting in tumor metastasis relapse. Combined checkpoint blockade (ICB) chemodynamic (CDT) could boost antitumor immunity, which may magnify responses of TAT. This study aims to discourage relapse by tri-model TAT-CDT-ICB strategy.We successfully designed Mn-based radioimmunotherapy promoters...
The naturally occurring compound α-pinene induces cell cycle arrest and antitumor activity. We examined effects of on regulation in hepatocellular carcinoma cells (HepG2) to establish a foundation for its development as novel treatment (HCC). HepG2 treated with exhibited dose-dependent growth inhibition result G2/M-phase arrest. Cell was associated down-regulated cyclin-dependent kinase 1 (CDK1) miR-221 levels up-regulated CDKN1B/p27, γ-H2AX, phosphorylated ATM, Chk2 p53. Our observations...
Small cell lung cancer (SCLC) is a neuroendocrine tumor with high degree of malignancy. Due to limited treatment options, patients SCLC have poor prognosis. We found, however, that intravenously administered octreotide (Oct) armed astatine-211 ([211At]SAB-Oct) effective against somatostatin receptor 2 (SSTR2)-positive in tumor-bearing BALB/c nude mice. In biodistribution analysis, [211At]SAB-Oct achieved the highest concentration tumors up 3 h after injection as time proceeded. A single...
Fuzheng huayu formula (FZHY), an antifibrotic traditional Chinese medicine, is frequently used for the treatment of liver fibrosis. In this study, network analysis, transcriptomic assays cell apoptosis, viability and protein expression were investigating effects mechanisms compounds derived from FZHY on hepatic parenchymal (HPC) protection stellate activation. Network pharmacology analysis found that 6 major 39 potential targets important nodes. Our predicted active FZHY, including...
Abstract Radium‐223 ( 223 Ra) is the first‐in‐class alpha‐emitter to mediate tumor eradication, which commonly thought kill cells by directly cleaving double‐strand DNA. However, immunogenic characteristics and cell death modalities triggered Ra remain unclear. Here, it reported that irradiation induces pro‐inflammatory damage‐associated molecular patterns including calreticulin, HMGB1, HSP70, hallmarks of immunogenicity. Moreover, therapeutic retards progression triggering pyroptosis, an...
Abstract Alpha emitters are radionuclides with good pharmacological characteristics for the treatment of cancer because they decay by emitting high linear energy transfer particles. Recent advancements in isotope production and purification generation novel techniques optimum targeting have led to development targeted alpha therapy (TAT). The great cytotoxic potential α‐particle emissions combined monoclonal antibodies, peptides, small compounds, or nanoparticles has investigations TAT...
Purpose This study aims to evaluate the diagnostic value of texture analysis for lymph node metastasis after thyroid cancer surgery. Methods We retrospectively analyzed patients who underwent positron emission tomography/computed tomography (PET/CT) examination before 131 I treatment at Shanghai Tenth People's Hospital between 2017 and 2020. Clinical follow-up results were used as criterion determining presence metastasis. The included 119 patients, then randomly divided into training test...
Germacrone is one of the major bioactive components in Curcuma zedoaria oil product, which extracted from Roscoe, known as zedoary. The present study designed some novel germacrone derivatives based on combination principles, synthesized these compounds, and investigated their inhibitions Bel-7402, HepG2, A549 HeLa cells. Meanwhile, evaluated c-Met kinase, has been detected a number cancers. results suggested that majority compounds showed stronger inhibitory effect cancers kinase than...
To investigate the mechanism of a Bushen-Jianpi decoction (BSJPD) in liver cancer (LC) treatment, we analyzed clinical therapy data, conducted network pharmacology analysis, and performed pharmacological experimental verification vitro vivo. The univariate analysis showed that BSJPD was protective factor (p < 0.05). 9 compounds were important nodes BSJPD-LC network. In verification, rate apoptosis increased tumors mice treated with 0.05); drug serum 20 % inhibited cell viability 0.05)...
There is a lack of effective therapeutic drugs in patients with postoperative colorectal cancer (PCRC). This study aimed to investigate the effect and mechanisms Bushen-Jianpi-Jiedu decoction (BSJPJDD) combined chemotherapeutic (oxaliplatin) on PCRC liver kidney yin deficiency spleen syndrome (LKYD-SDS) through evaluation clinical therapy integrative analysis network pharmacology, RNA-seq label-free data, experiment verification vitro . In therapy, median progression-free survival (PFS)...
To study the predictive value of B-type natriuretic peptide (BNP) and soluble thrombomodulin (sTM) in severity stratification prognosis evaluation sepsis.The clinical data 137 sepsis patients diagnosed treated Sichuan Provincial People's Hospital from May 2018 to November 2020 were retrospectively analyzed. Meanwhile, 121 healthy individuals selected as control group. Patients with allocated into mild group, severe shock group according severity. According 28-day prognosis, death survival...
Auricularia auricula (A. auricula) is one of the most abundant sources plant protein in edible fungi. Problems low yield exist traditional methods extraction such as alkali and ultrasonic-assisted after pretreatment with enzymes. Thus, process was investigated optimized using a definitive screening design from A. to improve under practical operating conditions temperature, concentration NaCl, meal/water ratio, time pH.The isolates isoelectric-ammonium sulfate precipitation (9.34% w/w)...
Edible mushroom proteins are the promising ones with advantages of complete essential amino acid profile and multiple functional activities. To reinforce their applications in food development, this study comprehensively evaluated physicochemical properties protein isolates from 5 species, i.e., <em>Pleurotus eryngii </em>(PEP), ostreatus </em>(POP), <em>Lentinula edodes </em>(LEP), <em>Flammulina velutipes </em>(FVP) <em>Hypsizygus marmoreus </em>(HMP). Results showed that PEP, LEP, FVP,...
Objective: The objective of the study is to explore traditional Chinese medicine (TCM) syndrome distribution in colorectal cancer (CRC) and its correlation with treatment methods clinical laboratory indicators. Materials Methods: Using CRC cases report form TCM, 760 patients TCM four diagnosis information, western information indicators were collected, syndromes summarized. between type treatments, such as liver kidney function, immune tumor biomarkers was analyzed. Results: In CRC, Spleen...
Abstract Triptolide (TPL), the active component of Tripterygium wilfordii, exhibits anti-cancer and antioxidant functions. We aimed to explore anti-apoptosis mechanism TPL based on network pharmacology in vivo vitro research validation using a rat model focal segmental glomerulosclerosis (FSGS). The chemical structures pharmacological activities compounds reported T. wilfordii were determined used perform analysis. Traditional Chinese Medicine Systems Pharmacology Database (TCMSP) was then...