A5101720254- Traditional Chinese Medicine Analysis
- Natural product bioactivities and synthesis
- Pharmacological Effects of Natural Compounds
- Traditional Chinese Medicine Studies
- Corneal Surgery and Treatments
- Ocular Surface and Contact Lens
- Phytochemistry and Biological Activities
- Medicinal Plant Pharmacodynamics Research
- Synthesis and Characterization of Heterocyclic Compounds
- Angiogenesis and VEGF in Cancer
- Corneal surgery and disorders
- Spectroscopy and Chemometric Analyses
- Plant-based Medicinal Research
- Inflammatory mediators and NSAID effects
- Cancer-related molecular mechanisms research
- Glaucoma and retinal disorders
- Carbohydrate Chemistry and Synthesis
- Bioactive Compounds and Antitumor Agents
- Machine Learning in Bioinformatics
- Biochemical and Structural Characterization
- Ginseng Biological Effects and Applications
- Developmental Biology and Gene Regulation
- Chemical Synthesis and Analysis
- Bacterial biofilms and quorum sensing
- Curcumin's Biomedical Applications
Guangdong Pharmaceutical University
2009-2023
Dazhou Central Hospital
2015-2021
Hebei University
2008
Quanta Computer (China)
2006
A prior knowledge of protein structural class can provide useful information about its overall structure. So, it is vitally important to develop a computational prediction method for fast and accurately determining the class. In this paper, dual-layer wavelet support vector machine (WSVM) presented via general form Chou’s pseudo amino acid composition, which featured by introducing as kernel making decisions fusion from three individual classifiers. As demonstration, rigorous jackknife...
Germacrone is one of the major bioactive components in Curcuma zedoaria oil product, which extracted from Roscoe, known as zedoary. The present study designed some novel germacrone derivatives based on combination principles, synthesized these compounds, and investigated their inhibitions Bel-7402, HepG2, A549 HeLa cells. Meanwhile, evaluated c-Met kinase, has been detected a number cancers. results suggested that majority compounds showed stronger inhibitory effect cancers kinase than...
Six pentasaccharide resin glycosides from Ipomoea cairica, including four new acylated glycosides, namely cairicoside I–IV (1–4) and the two known compounds A (5) C (6), were isolated aerial parts of cairica. Their structures established by a combination spectroscopic, dimensional (2D) NMR chemical methods. The core six was simonic acid A, they esterfied same sites, just differing in substituent groups. lactonization site aglycone bonded to second saccharide moiety at C-2 1–4, C-3 5–6....
Staphylococcus epidermidis infections are an important concern in worldwide, especially when associated with biofilms, and resistance of this agent to many drugs makes the situation even worse. We investigated inhibitory effect Disaspidin BB obtained from plant extracts purifications on clinical S. strains their preliminarily its mechanism anti-biofilm activity.The broth dilution method was used determine minimum concentrations (MIC) 11 (MIC value 0.63 ~ 2.5 μg/ml). SEP-05 found be...
To investigate the effect and mechanism of linarin (LA) in an experimental dry eye model LA or vehicle was applied two models: vitro hyperosmotic stress vivo desiccating (DS) murine model. The viability human corneal epithelial cells (HCECs) measured using a cell counting kit (CCK-8). Tear secretion assessed phenol red cotton test. tear break-up time (TBUT) recorded 0.1% liquid fluorescein sodium. Corneal permeability evaluated through Oregon green dextran (OGD) staining. Conjunctival goblet...
LncRNA SNHG1 (SNHG1) has been widely studied as the causative factor of angiogenesis and proliferative agent in gastric, lung, cervical, hepatocellular carcinomas. However, its significance progression corneal neovascularization (CRNV) is least understood. This study focuses on molecular mechanisms followed by to establish CRNV angiogenesis. Bioinformatics analysis identify potential miRNA targets vascular endothelial growth A (VEGF-A) was conducted using StarBase subsequently confirmed...