A5100357467- Chemokine receptors and signaling
- Drug Transport and Resistance Mechanisms
- Immunotherapy and Immune Responses
- Monoclonal and Polyclonal Antibodies Research
- Cancer Cells and Metastasis
- Lymphoma Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Cardiac pacing and defibrillation studies
- Medical Imaging Techniques and Applications
- Metal complexes synthesis and properties
- Cytokine Signaling Pathways and Interactions
- Immune Cell Function and Interaction
- Cancer Mechanisms and Therapy
- Radiomics and Machine Learning in Medical Imaging
- Computational Drug Discovery Methods
- Prostate Cancer Treatment and Research
- Lung Cancer Research Studies
- CAR-T cell therapy research
- Peptidase Inhibition and Analysis
- Chemical Synthesis and Analysis
- Microtubule and mitosis dynamics
- Radiopharmaceutical Chemistry and Applications
- Lanthanide and Transition Metal Complexes
- Cancer Risks and Factors
- Synthesis and Characterization of Heterocyclic Compounds
Henan Polytechnic University
2025
Qilu Hospital of Shandong University
2023-2024
Tongji University
2023
Nanjing Medical University
2023
Shanghai Tenth People's Hospital
2023
First Affiliated Hospital of Guangzhou Medical University
2023
State Key Laboratory of Respiratory Disease
2023
Guangzhou Medical University
2023
Wuhan University
2021-2022
Renmin Hospital of Wuhan University
2021-2022
Abstract Emerging evidence demonstrates that stromal cell-derived factor 1 (SDF-1) and CXCR4, a chemokine receptor pair, play important roles in tumorigenesis. In this report, we describe small cyclic peptide, LY2510924, which is potent selective CXCR4 antagonist currently phase II clinical studies for cancer. LY2510924 specifically blocked SDF-1 binding to with IC50 value of 0.079 nmol/L, inhibited SDF-1–induced GTP Kb 0.38 nmol/L. human lymphoma U937 cells expressing endogenous cell...
A number of epidemiological studies have suggested that obesity is associated, albeit inconsistently, with the incidence prostate cancer (PCa). In order to provide a quantitative assessment this association, present study examined correlation between and associated mortalities PCa in an updated meta‑analysis cohort studies. The were identified by searching EMBASE MEDLINE databases on January 1, 2014. summary relative risks (RRs) 95% confidence intervals (CIs) calculated using random‑effects...
SDF-1 and CXCR4 are a chemokine receptor pair playing critical roles in tumorigenesis. Overexpression of is hallmark many hematological malignancies including acute myeloid leukemia, chronic lymphocytic leukemia non-Hodgkin's lymphoma, generally correlates with poor prognosis. In this study, we developed humanized anti-CXCR4 monoclonal antibody, LY2624587 as potent antagonist that was advanced into clinical study for cancer. blocked binding to an IC50 0.26 nM, inhibited SDF-1-induced GTP Kb...
In the present study, we aimed to evaluate prognostic value of PET/CT-derived radiomic features for patients with B-cell lymphoma (BCL), who were treated CD19/CD22 dual-targeted chimeric antigen receptor (CAR) T cells. Moreover, explored relationship between baseline and occurrence probability cytokine release syndrome (CRS).A total 24 BCL received 18F-FDG PET/CT before CAR T-cell infusion enrolled in study. Radiomic from PET CT images extracted using LIFEx software, least absolute shrinkage...
Abstract Objective We aimed to evaluate the correlation of circular RNA La‐related RNA‐binding protein 4 (circ‐LARP4) with tumor characteristics and prognosis, its effect on chemosensitivity in breast cancer. Methods Circ‐LARP4 from adjacent tissues 283 female cancer patients underwent resection was detected by reverse transcription‐quantitative polymerase chain reaction (RT‐qPCR). Tumor features, disease‐free survival (DFS), overall (OS) were recorded. In vitro, circ‐LARP4 human normal...
The tumor immune microenvironment (TIME) has been recognized to be an imperative factor facilitating the acquisition of many cancer-related hallmarks and is a critical target for targeted biological therapy. This research intended construct risk score model premised on TIME-associated genes prediction survival identification potential drugs ovarian cancer (OC) patients.The stromal scores were computed utilizing ESTIMATE algorithm in OC patient samples from Cancer Genome Atlas (TCGA)...
Abstract Alpha emitters are radionuclides with good pharmacological characteristics for the treatment of cancer because they decay by emitting high linear energy transfer particles. Recent advancements in isotope production and purification generation novel techniques optimum targeting have led to development targeted alpha therapy (TAT). The great cytotoxic potential α‐particle emissions combined monoclonal antibodies, peptides, small compounds, or nanoparticles has investigations TAT...
A mild and general strategy for the direct generation of alkoxy radicals from simple aliphatic alcohols enabled by visible-light-induced photoredox/persistent radical cation dual catalysis is developed.
Some individuals with acute pancreatitis (AP) suffer from pancreatic necrosis. Diabetes affects the severity of AP, but whether diabetes influences necrosis is unclear. This study aims to investigate clinical characteristics AP patients and without as well analyze risk factors necrosis.A total 625 participated in study. Clinical laboratory data were retrieved. Multivariate logistic regression analysis was used identify for ROC curves assess accuracy indicators predicting AP.AP had high BMI,...
The present study aimed to investigate correlations between uridine glucuronosyltransferase 2B7 (UGT2B7) -161 single nucleotide polymorphism C T (C>T) and the occurrence of cardiotoxicity in Chinese breast cancer (BC) patients undergoing epirubicin/cyclophosphamide-docetaxel (EC-D) adjuvant chemotherapy.427 BC who had underwent surgery were consecutively enrolled this prospective cohort study. All scheduled receive EC-D chemotherapy regimen, they divided into UGT2B7 CC (n=141), CT (n=196),...
Gemcitabine has been widely used as a chemotherapeutic drug. However, drug resistance, short half-life and side effects seriously decrease its efficacy.The object of preparing RGDV-gemcitabine was to prolong the half-life, overcome resistance eliminate bone marrow toxicity gemcitabine.Arg-Gly-Asp-Val coupled with gemcitabine, forming 4-(Arg-Gly-Asp-Val-amino)-1-[3,3-difluoro-4-hydroxy-5-(hydroxylmethyl)oxo-lan-2-yl]pyrimidin-2-one (RGDV-gemcitabine) involving 9-step reactions. The advantages...
Purpose . In the present study, we aimed to investigate whether metabolic parameters on baseline 18 F-fluorodeoxyglucose positron emission tomography/computed tomography ( F-FDG PET/CT) could be used predict prognosis in peripheral T-cell lymphomas (PTCL). Methods A total of 51 nodal PTCL patients who underwent PET/CT were retrospectively evaluated study. Total tumor volume (TMTV), lesion glycolysis (TLG), and maximum standardized uptake value (SUV max ) also assessed. Besides, National...
To investigate the function and regulatory mechanisms of delphinidin in treatment hepatocellular carcinoma.HepG2 HuH-7 cells were treated with different concentrations delphinidin. Cell viability was analysed by 3-(4,5-dimethyl-thiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. The cell autophagy autophagic flux LC3b-green fluorescent protein (GFP)-Adv LC3b-GFP-monomeric red protein-Adv transfected HepG2 cells, respectively. apoptosis Hoechst33342 staining, terminal deoxynucleotidyl...
Cisplatin (DDP) resistance limits therapeutic efficacy in patients diagnosed with ovarian cancer. Purvalanol A (Pur) is a novel cyclin-dependent kinase (CDK) inhibitor that has been demonstrated to induce apoptosis various cancer cells. The present study investigated the effect of combination treatment Pur and DDP, potential anticancer mechanisms epithelial (EOC) cells vitro vivo . We found enhanced anti-tumor cisplatin EOC DDP had more significant effects on induction compared...
Abstract The insufficient number of cells suitable for transplantation is a long‐standing problem to cell‐based therapies aimed at tissue regeneration. Xenogeneic cancer (XCC) may be an alternative source therapeutic cells, but their risks both immune rejection and unwanted spreading. In this study, strategy facilitate XCC reported spreading in vivo confined by constructing engineering matrix that mimics the characteristics tumor microenvironment. data show matrix, homogenate‐containing...
To find novel nano-materials with anti-osteoporosis activity and without side effects three active amphiphiles, 17β-(RGD-AA-amido)-11α-hydroxyandrost-1,4-diene-3-one (5a: AA = Ser, 5b: Val, 5c: Phe), were constructed by coupling the bone resorption inhibiting RGD-peptides 17β-amino-11α-hydroxyandrost-1,4-diene-3-one. In solid state 5a, 5b 5c exist as dispersed globes of 300 nm–14 μm in diameter, eggs 110 nm–19 diameter beads 238 nm–22 respectively. ultrapure water 1.1 μM form nano-globes...