A5060557882- Chemotherapy-induced cardiotoxicity and mitigation
- Cardiac Ischemia and Reperfusion
- Advancements in Battery Materials
- RNA modifications and cancer
- Traditional Chinese Medicine Analysis
- Mitochondrial Function and Pathology
- RNA Research and Splicing
- Graphene research and applications
- PARP inhibition in cancer therapy
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- Electron Spin Resonance Studies
- Autophagy in Disease and Therapy
- MicroRNA in disease regulation
- Cell death mechanisms and regulation
- Epigenetics and DNA Methylation
- Cancer-related cognitive impairment studies
- Neonatal and fetal brain pathology
- Endoplasmic Reticulum Stress and Disease
- Analytical Chemistry and Sensors
- Quality Function Deployment in Product Design
- Boron and Carbon Nanomaterials Research
- Drug Transport and Resistance Mechanisms
- Bone Metabolism and Diseases
- Cardiac Fibrosis and Remodeling
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2024
Academia Sinica
2021
Chinese Academy of Sciences
2020
University of Science and Technology Liaoning
2020
University of Science and Technology of China
2020
Hebei University of Technology
2017
Abstract DEAD-box helicase 17 (DDX17) is a typical member of the family with transcriptional cofactor activity. Although DDX17 abundantly expressed in myocardium, its role heart not fully understood. We generated cardiomyocyte-specific Ddx17- knockout mice ( Ddx17 -cKO), transgenic -Tg), and various models cardiomyocyte injury failure (HF). downregulated myocardium mouse injury. Cardiomyocyte-specific promotes autophagic flux blockage apoptosis, leading to progressive cardiac dysfunction,...
The usage of doxorubicin is hampered by its life-threatening cardiotoxicity in clinical practice. Dexrazoxane the only cardioprotective medicine approved FDA for preventing doxorubicin-induced cardiac toxicity. Nevertheless, mechanism dexrazoxane incompletely understood. aim our study to investigate possible molecular against cardiotoxicity. We established a mouse and cardiomyocyte injury model. Male C57BL/6J mice were randomly distributed into control group (Con), treatment (DOX), plus...
To investigate the protective effects and regulatory mechanism of miR-488-3p on doxorubicin-induced cardiotoxicity. The C57BL/6 mice primary cardiomyocytes were used to construct cardiomyocyte injury models in vivo vitro. levels its downstream target genes analyzed by quantitative real-time PCR. Mouse cardiac function, cell survival, cellular injury-related proteins, apoptosis level echocardiography, MTT analysis, Western blotting, DNA laddering separately. Cardiomyocyte caused a variety...
To investigate the function and regulatory mechanisms of delphinidin in treatment hepatocellular carcinoma.HepG2 HuH-7 cells were treated with different concentrations delphinidin. Cell viability was analysed by 3-(4,5-dimethyl-thiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. The cell autophagy autophagic flux LC3b-green fluorescent protein (GFP)-Adv LC3b-GFP-monomeric red protein-Adv transfected HepG2 cells, respectively. apoptosis Hoechst33342 staining, terminal deoxynucleotidyl...
To investigate the protective effects and regulatory mechanisms of ferulic acid on oxidative stress-induced cardiomyocyte injury.We established a stress cell model by H2O2 treatment mouse heart injury isoprenaline infusion male C57BL/6 mice. Ferulic was applied to treat injury. DHE staining used detect ROS production. DNA fragmentation, TUNEL assay, cleaved caspase-3 were analyze apoptosis. Real-time PCR Western blotting miRNA protein levels injury.Ferulic pretreatment significantly...
Understanding the bonding mechanisms between carbon and metal atoms are crucial for experimental preparations of low-dimensional materials metal/low-dimensional composites. In this work, various modes summarized through a systematical study on adsorptions graphene graphyne surfaces typical transition metals. If atom is adjacent to atom, C-p z electron may form covalent bond with s or d atom. When lies below two graphyne, new bonds be formed by electrons sd-hybridized orbital Specially,...
Abstract A series of adsorption configurations with less than 2% lattice mismatch graphyne adsorbed at different sites on the (111) surface Cu, Ag and Au are obtained by a systematic rotation sheet. Besides, all non-equivalent metal surfaces structure screening method based translation sheet calculation atomic overlapping area interface. The most stable configuration each is optimizing these small computational cost. Then energy, differential charge density, partial density states calculated...
In the modern TRIZ, function analysis is often used to analyze complex system whose principles are difficult understand or confuse problems needed identify. this paper, build Numeric Design Structure Matrix (NDSM) of system, and then we cluster components into four modules according Genetic algorithm. Finally, law completeness introduced identify type module judge degree idealization each module. As a result, problem scope ascertained.