A5101488231- Radiopharmaceutical Chemistry and Applications
- Radiomics and Machine Learning in Medical Imaging
- Cardiac Imaging and Diagnostics
- Medical Imaging Techniques and Applications
- Glycosylation and Glycoproteins Research
- Nanoplatforms for cancer theranostics
- Neuroendocrine Tumor Research Advances
- Thyroid Cancer Diagnosis and Treatment
- Electrospun Nanofibers in Biomedical Applications
- interferon and immune responses
- Tissue Engineering and Regenerative Medicine
- Advanced MRI Techniques and Applications
- Peptidase Inhibition and Analysis
- Cardiac pacing and defibrillation studies
- Transgenic Plants and Applications
- Inflammasome and immune disorders
- Lung Cancer Research Studies
- Cardiovascular Function and Risk Factors
- Cancer Immunotherapy and Biomarkers
- Cancer, Stress, Anesthesia, and Immune Response
- Carbohydrate Chemistry and Synthesis
- Advanced X-ray and CT Imaging
- Artificial Intelligence in Healthcare and Education
- Management of metastatic bone disease
- Protease and Inhibitor Mechanisms
Shanghai Tenth People's Hospital
2016-2024
Tongji University
2016-2024
Tibet University
2023-2024
Southwest Jiaotong University
2023
Cochrane
2023
Chengdu Third People's Hospital
2023
Bridge University
2023
Sichuan University
2023
North Sichuan Medical University
2023
Qingdao University
2022
Emerging evidence suggests that the essence of life is ecological balance neural, endocrine, metabolic, microbial, and immune systems. Gut microbiota have been implicated as an important factor affecting thyroid homeostasis.This study aims to explore relationship between gut development carcinoma.Stool samples were collected from 90 carcinoma patients (TCs) healthy controls (HCs). Microbiota analyzed using 16S ribosomal RNA gene sequencing. A cross-sectional exploratory cohort 60 TCs HCs was...
Similar to other local therapeutic methods, interstitial radiotherapy (IRT) also suffers from insufficient systematic immune activation, resulting in tumor metastasis.Mn-based IRT radiosensitizers consisting of 131I, MnO2 and bovine serum albumin (BSA) (131I-MnO2-BSA) were engineered. Such Mn-based successfully unlocked radiogenetics magnify responses via remodeling hypoxic immunosuppressive microenvironments resist metastasis. The 131I-MnO2-BSA caused decomposition H2O2 enriched tumors...
Astatine-211 is an α-emitter with high-energy α-ray and high cytotoxicity for cancer cells. However, the targeted alpha therapy (TAT) also suffers from insufficient systematic immune activation, resulting in tumor metastasis relapse. Combined checkpoint blockade (ICB) chemodynamic (CDT) could boost antitumor immunity, which may magnify responses of TAT. This study aims to discourage relapse by tri-model TAT-CDT-ICB strategy.We successfully designed Mn-based radioimmunotherapy promoters...
Small cell lung cancer (SCLC) is a neuroendocrine tumor with high degree of malignancy. Due to limited treatment options, patients SCLC have poor prognosis. We found, however, that intravenously administered octreotide (Oct) armed astatine-211 ([211At]SAB-Oct) effective against somatostatin receptor 2 (SSTR2)-positive in tumor-bearing BALB/c nude mice. In biodistribution analysis, [211At]SAB-Oct achieved the highest concentration tumors up 3 h after injection as time proceeded. A single...
Abstract Radium‐223 ( 223 Ra) is the first‐in‐class alpha‐emitter to mediate tumor eradication, which commonly thought kill cells by directly cleaving double‐strand DNA. However, immunogenic characteristics and cell death modalities triggered Ra remain unclear. Here, it reported that irradiation induces pro‐inflammatory damage‐associated molecular patterns including calreticulin, HMGB1, HSP70, hallmarks of immunogenicity. Moreover, therapeutic retards progression triggering pyroptosis, an...
Abstract Alpha emitters are radionuclides with good pharmacological characteristics for the treatment of cancer because they decay by emitting high linear energy transfer particles. Recent advancements in isotope production and purification generation novel techniques optimum targeting have led to development targeted alpha therapy (TAT). The great cytotoxic potential α‐particle emissions combined monoclonal antibodies, peptides, small compounds, or nanoparticles has investigations TAT...
Purpose This study aims to evaluate the diagnostic value of texture analysis for lymph node metastasis after thyroid cancer surgery. Methods We retrospectively analyzed patients who underwent positron emission tomography/computed tomography (PET/CT) examination before 131 I treatment at Shanghai Tenth People's Hospital between 2017 and 2020. Clinical follow-up results were used as criterion determining presence metastasis. The included 119 patients, then randomly divided into training test...
To clarify the association between carboplatin and electrolyte abnormality, a pooled-analysis was performed with adverse event reports of non-small cell lung cancer patients. A total 19901 events were retrieved from FDA Adverse Event Reporting System (FAERS). Pooled reporting odds ratios (RORs) 95% CIs suggested that significantly associated hyponatremia (pooled ROR = 1.57, CI 1.18-2.09, P 1.99×10-3) hypokalemia 2.37, 1.80-3.10, 5.24×10-10) as compared to other therapies. In addition, we...
Purpose: To evaluate the value of texture analysis for differential diagnosis spinal metastases and to improve diagnostic performance 2-deoxy-2-[fluorine-18]fluoro-D-glucose positron emission tomography/computed tomography ( 18 F-FDG PET/CT) metastases. Methods: This retrospective patients who underwent PET/CT between December 2015 January 2020 at Shanghai Tenth People's Hospital due high FDG uptake lesions in spine included 45 cases 44 benign spine. The were randomly divided into a training...
Background The risk stratification of patients with ischemia and no obstructive coronary artery disease (INOCA) remains suboptimal. This study aims to establish a left ventricular mechanical dyssynchrony (LVMD)-based nomogram improve the present situation. Methods Patients suspected (CAD) were retrospectively enrolled divided into three groups: normal (stenosis <50%, without myocardial ischemia), INOCA summed stress score >4, difference ≥2), CAD ≥50%). LVMD was defined by ROC...
Background Ischemia and no obstructive coronary artery disease (INOCA) patients who presented microvascular dysfunction (CMD) demonstrate a poor prognosis, yet the risk factors for CMD remain unclear. Subtle changes in thyroid hormone levels within normal range, especially free thyroxine (FT4)/free triiodothyronine (FT3) ratio, have been shown to regulate cardiovascular system. This prospective study investigated correlation between FT4/FT3 ratio euthyroid with INOCA. Methods (...
Abstract Background Due to spatial resolution limitations, conventional NaI-SPECT typically overestimates the left ventricular (LV) ejection fraction (EF) in patients with small LV volumes. The purpose of this study was explore clinical application value heart (SH) reconstruction protocol embedded postprocessing procedure D-SPECT. Methods We retrospectively analyzed who undergo both D-SPECT and echocardiography (Echo) within one week. Patients volume were defined as those a rest end-systolic...
The potential molecular mechanisms of short-term adaptation and long-term structural deteriorations in the cardiac structure response to high altitude remain not fully understood. This study aims investigate changes crotonylproteome hearts mice exposed at different time points. were obtained from living lowland 3, 10, 30 days after arriving a plateau. Crotonyllysolylated proteins subsequently comprehensively evaluated. Among identified 13,731 crotonyllysine sites, 11,140 quantified....