A5024866304- Target Tracking and Data Fusion in Sensor Networks
- Cancer-related molecular mechanisms research
- Inertial Sensor and Navigation
- MicroRNA in disease regulation
- Advanced Computational Techniques and Applications
- Circular RNAs in diseases
- Remote Sensing and Land Use
- Gut microbiota and health
- Advanced Algorithms and Applications
- Numerical methods for differential equations
- Statistical and numerical algorithms
- Differential Equations and Numerical Methods
- Thyroid Disorders and Treatments
- Thyroid Cancer Diagnosis and Treatment
- Landslides and related hazards
- Cancer-related gene regulation
- GNSS positioning and interference
- Control Systems and Identification
- Matrix Theory and Algorithms
- Direction-of-Arrival Estimation Techniques
- Water Quality Monitoring and Analysis
- Protein Tyrosine Phosphatases
- Parasitic infections in humans and animals
- Image Processing and 3D Reconstruction
- Neuroendocrine Tumor Research Advances
Shanghai Tenth People's Hospital
2018-2024
Tongji University
2018-2024
Tsinghua University
2022
Central South University
2006-2021
Hunan Nonferrous Metal Research Institute
2021
Affiliated Hospital of Chengde Medical College
2019-2021
First Hospital of Xi'an
2019
China XD Group (China)
2019
Harbin University of Science and Technology
2003-2016
Shenyang University of Chemical Technology
2009
Emerging evidence suggests that the essence of life is ecological balance neural, endocrine, metabolic, microbial, and immune systems. Gut microbiota have been implicated as an important factor affecting thyroid homeostasis.This study aims to explore relationship between gut development carcinoma.Stool samples were collected from 90 carcinoma patients (TCs) healthy controls (HCs). Microbiota analyzed using 16S ribosomal RNA gene sequencing. A cross-sectional exploratory cohort 60 TCs HCs was...
Background: Gut microbiota are considered to be intrinsic regulators of thyroid autoimmunity. We designed a cross-sectional study examine the makeup and metabolic function in Graves' disease (GD) patients, with ultimate aim offering new perspectives on diagnosis treatment GD. Methods: The 16S ribosomal RNA (rRNA) V3-V4 DNA regions were obtained from fecal samples collected 45 GD patients 59 controls. Microbial differences between two groups subsequently analyzed based high-throughput...
Dogs are pivotal in Echinococcus granulosus transmission to humans, and dog vaccination provides a very practical cost-effective prevention strategy. We vaccinated dogs with soluble native proteins isolated from protoscoleces of E. induced significant suppression worm growth egg production. Accordingly, we tested for vaccine efficacy using recombinant derived developmentally regulated gene family (egM) specifically expressed mature adult worms. Three egM genes--egM4, egM9, egM123--were...
Background/Aims: Forkhead box D1 (FOXD1) has a well-established role in early embryonic development and organogenesis functions as an oncogene several cancers. However, the clinical significance biological roles of FOXD1 non-small cell lung cancer (NSCLC) remain largely unknown. Methods: A total 264 primary NSCLC tissue samples were collected. The expression levels these examined by immunohistochemical staining. was knocked down lentiviral shRNA. relative determined qRT-PCR, Western blotting...
The long noncoding RNA (lncRNA), HOX antisense intergenic myeloid 1 (HOTAIRM1), has been shown to act as a tumor suppressor in various human cancers. However, the overall biological roles and clinical significance of HOTAIRM1 papillary thyroid cancer (PTC) have not investigated. In this study, we used quantitative reverse transcription PCR (qRT-PCR) show that was significantly downregulated PTC tissues low expression levels were associated with lymph node metastasis advanced TNM stage. We...
Long non-coding RNA-ATB (Lnc-ATB) have been reported to promote tumor proliferation and metastasis via regulation of suppressive miRNA-related signals. Patients with endometrial cancer (EC) advanced stage disease or poor prognosis. We here investigated the role Lnc-ATB in cancer.Endometrial tissues normal (n = 35) were collected determine expression clinical significance Lnc-ATB, bioinformatics analysis was used predict miRNA target. siRNA estimate function EC cell lines vivo.The is...
Osteoarthritis (OA) is a common type of degenerative joint diseases that regulated by combination complex intercellular signals and modulators, including non-coding RNAs. Mounting evidence suggests miR-31-5p physiologically involved in the regulation chondrocytes, but mechanism remains unclear.Expression levels SOX4 OA cartilage tissues IL-1β-stimulated chondrocytes were examined quantification polymerase chain reaction (q-PCR) or immunohistochemistry assays. Cell proliferation apoptosis...
To investigate the expression level of microRNA-101-3p (miR-101-3p) and its possible association with progression, prognosis chemotherapy in patients non-small cell lung cancer (NSCLC), Gene Expression Omnibus (GEO) database was used. Quantitative polymerase chain reaction used to verify 327 NSCLC 42 adjacent normal tissues, which viable tissues were paired nearby tissues. Based on Cox regression model, univariate multivariate analyses address factors that had effects overall survival (OS)...
Osteoarthritis (OA) is a degenerative disease characterized by progressive articular cartilage destruction and joint marginal osteophyte formation with different degrees of synovitis. Docosahexaenoic acid (DHA) an unsaturated fatty anti-inflammatory, antioxidant, antiapoptotic functions. In this study, the human chondrosarcoma cell line SW1353 was cultured in vitro, OA model constructed inflammatory factor IL-1β stimulation. After cells were treated DHA, apoptosis measured. Western blot...
Ischemia-reperfusion (I/R) injury is the main cause of acute kidney (AKI), and its incidence mortality increase year by in population. Dexmedetomidine (DEX) can improve AKI regulating inflammation oxidative stress, but mechanism still unclear.A hypoxia/reoxygenation (H/R) model HK-2 cells a I/R C57BL/6J mice were established. In experiment, transfected with sh-PGC-1α to inhibit PGC-1α expression. The changes ROS level mitochondrial membrane potential (MMP) analyzed. HE staining was used...
Chemokines have been suggested to play significant roles in the progression of malignant cancers. This study aimed identify chemokines related thyroid carcinoma.The mRNA expression levels 52 were compared between differentiated cancer (DTC) samples and normal tissues from The Cancer Genome Atlas database; survival analysis was then performed on basis differentially expressed chemokines. A retrospective conducted level 76 DTC patients. Functional pathway explore chemokine-related regulatory...
This paper studies the least-squares estimation of adjustment model constrained by some non-negative parameters from an entirely novel point view. The parameters-constrained least-square problems are first translated to convex quadratic programming and then searched for optimal solutions. gives necessary sufficient conditions on solvability optimization problem, which consequently general form parameters. A simple straightforward algorithm is designed resolve problem. Comparative...
In order to analyze the expression level of zinc finger matrin-type protein 4 (ZMAT4) gene in T cells thyroid carcinoma (TC) tissue and its clinical significance prognosis patients based on bioinformatics reverse transcription polymerase chain reaction (RT-PCR), 389 TC with ZMAT4 corresponding survival are searched by Cancer Genome Atlas database. The is compared between normal RT-PCR. relationship levels clinicopathological parameters baseline data analyzed. experimental results show that...
Embryonal carcinoma (EC) and seminoma (SE) are both derived from germ cell neoplasia in situ but show big differences growth patterns clinical prognosis. Epigenetic regulation may play an important role the development of EC SE. This study investigated DNA methylation-based genetic alterations between SE by analyzing datasets mRNA expression methylation profiling. The were downloaded Gene Expression Omnibus database. differentially expressed genes (DEGs) identified limma package R...