A5039640617- Parasites and Host Interactions
- Parasite Biology and Host Interactions
- Helminth infection and control
- Parasitic infections in humans and animals
- Trace Elements in Health
- Parasitic Infections and Diagnostics
- Research on Leishmaniasis Studies
- Congenital Anomalies and Fetal Surgery
- Mosquito-borne diseases and control
- Amoebic Infections and Treatments
- Malaria Research and Control
- Mollusks and Parasites Studies
- Viral Infections and Vectors
- Ichthyology and Marine Biology
- Nematode management and characterization studies
- Dermatological diseases and infestations
- Marine Ecology and Invasive Species
- Iron Metabolism and Disorders
- SARS-CoV-2 and COVID-19 Research
- Marine Biology and Environmental Chemistry
- Vector-borne infectious diseases
- Insect and Arachnid Ecology and Behavior
- S100 Proteins and Annexins
- CRISPR and Genetic Engineering
- Child Nutrition and Water Access
The University of Queensland
2016-2025
QIMR Berghofer Medical Research Institute
2014-2025
University of Virginia
2023-2024
Vitalant
2024
Bloodworks Northwest
2013
University of Sheffield
1998-2010
Walter and Eliza Hall Institute of Medical Research
2008
University of Nevada, Reno
2006
Western Sydney University
2006
University of Aberdeen
2004
The subcellular location of the nonstructural proteins NS1, NS2B, and NS3 in Vero cells infected with flavivirus Kunjin was investigated using indirect immunofluorescence cryoimmunoelectron microscopy monospecific antibodies. Comparisons were also made by dual immunolabelling antibodies to double-stranded RNA (dsRNA), putative template replication complex. At 8 h postinfection, immunofluorescent patterns showed NS3, dsRNA located a perinuclear rim extensions into peripheral cytoplasm. By 16...
Cystic echinococcosis (hydatid disease), caused by the tapeworm E. granulosus, is responsible for considerable human morbidity and mortality. This cosmopolitan disease difficult to diagnose, treat control. We present a draft genomic sequence worm comprising 151.6 Mb encoding 11,325 genes. Comparisons with genome sequences from other taxa show that granulosus has acquired spectrum of genes, including EgAgB family, whose products are secreted parasite interact redirect host immune responses....
Background. Throughout Asia, there is an unprecedented link between cholangiocarcinoma and infection with the liver fluke Opisthorchis viverrini. Multiple processes, including chronic inflammation secretion of parasite proteins into biliary epithelium, drive toward cancer. Until now, mechanism effects protein entry cholangiocytes was unknown.
Infection with the human liver fluke, Opisthorchis viverrini, is a serious public health problem in Thailand, Laos and nearby locations Southeast Asia. Both experimental epidemiological evidence strongly implicate fluke infection etiology of one cancer subtypes, cholangiocarcinoma (CCA). To identify parasite proteins critical for survival CCA, OFFGEL electrophoresis multiple reaction monitoring were employed to characterize 300 from O. viverrini excretory/secretory products and, utilizing...
Schistosomes express a family of integral membrane proteins, called tetraspanins (TSPs), in the outer surface membranes tegument. Two these tetraspanins, Sm-TSP-1 and Sm-TSP-2, confer protection as vaccines mice, individuals who are naturally resistant to S. mansoni infection mount strong IgG response Sm-TSP-2. To determine their functions tegument we used RNA interference silence expression Sm-tsp-1 Sm-tsp-2 mRNAs. Soaking parasites Sm-tsp dsRNAs resulted 61% (p = 0.009) 74% reductions...
The world is experiencing a major pandemic caused by SARS-CoV-2, the Coronavirus causing COVID-19. This disease first entered human population in Hubei province, China, mid-November 2019 and manifested Wuhan, largest metropolitan area of Hubei, when cluster patients were admitted to hospital with ‘severe pneumonia unknown cause’ early December. Although humanity has survived previous pandemics infectious agents, present one unprecedented its capacity take advantage modern globalization...
Schistosomiasis is a disease that significantly impacts human health in the developing world. Effective diagnostics are urgently needed for improved control of this disease. CRISPR-based technology has rapidly accelerated development revolutionary and powerful platform, resulting advancement class ultrasensitive, specific, cost-effective portable diagnostics, typified by applications COVID-19/cancer diagnosis.
Replication of the flavivirus Kunjin virus is associated with virus-induced membrane structures within cytoplasm infected cells; these membranes appear as packets vesicles sites viral RNA synthesis and convoluted (CM) paracrystalline arrays (PC) containing components virus-specified protease (E. G. Westaway, J. M. Mackenzie, T. Kenney, K. Jones, A. Khromykh, Virol. 71:6650-6661, 1997). To determine cellular origins structures, we compared immunolabelling patterns several cell markers in...
Schistosomiasis continues to be an important cause of parasitic morbidity and mortality world-wide. Determining the molecular mechanisms regulating development granulomas fibrosis will essential for understanding how schistosome antigens interact with host environment. We report here first whole genome microarray analysis murine liver during progression Schistosoma japonicum egg-induced granuloma formation hepatic fibrosis. Our results reveal a distinct temporal relationship between...
To determine the true community prevalence of human cystic (CE) and alveolar (AE) echinococcosis (hydatid disease) in a highly endemic region Ningxia Hui, China, by detecting asymptomatic cases.Using hospital records "AE-risk" landscape patterns we selected study communities predicted to be at risk Guyuan, Longde Xiji counties. We conducted surveys 4773 individuals from 26 villages 2002 2003 using questionnaire analysis, ultrasound examination serology.Ultrasound serology showed range...
Abstract Hemoparasites, like malaria and schistosomes, are constantly faced with the challenges of storing detoxifying large quantities heme, released from their catabolism host erythrocytes. Heme is an essential prosthetic group that forms reactive core numerous hemoproteins diverse biological functions. However, due to its nature, it also a potentially toxic molecule. Thus, acquisition detoxification heme likely be paramount for survival establishment parasitism. Understanding underlying...
Control initiatives have successfully reduced the prevalence and intensity of schistosomiasis transmission in several localities around world. However, individuals that release low numbers eggs their feces may not be detected by classical methods are limited sensitivity. Given accurate estimates key to implementing planning control actions for elimination schistosomiasis, new diagnostic tools needed effectively monitor infections confirm interruption. The World Health Organization recommends...
Mesenteric infection by the parasitic blood fluke Schistosoma bovis is a common veterinary problem in Africa and Middle East occasionally Mediterranean Region. The species also has ability to form interspecific hybrids with human parasite S. haematobium natural hybridisation observed West Africa, presenting possible zoonotic transmission. Additionally, this exchange of alleles between may dramatically influence disease dynamics evolution. We have generated 374 Mb assembly genome using...