A5028053683- Scoliosis diagnosis and treatment
- Spinal Fractures and Fixation Techniques
- Spine and Intervertebral Disc Pathology
- MicroRNA in disease regulation
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Radiomics and Machine Learning in Medical Imaging
- Connective tissue disorders research
- Medical Imaging and Analysis
- Artificial Intelligence in Healthcare and Education
- Intraoperative Neuromonitoring and Anesthetic Effects
- Pelvic and Acetabular Injuries
- Protease and Inhibitor Mechanisms
- Cervical and Thoracic Myelopathy
- Respiratory viral infections research
- Cancer, Lipids, and Metabolism
- Gastric Cancer Management and Outcomes
- Brain Tumor Detection and Classification
- Genomics, phytochemicals, and oxidative stress
- Liver Disease Diagnosis and Treatment
- Vitamin C and Antioxidants Research
- Endoplasmic Reticulum Stress and Disease
- Alcoholism and Thiamine Deficiency
- Cholangiocarcinoma and Gallbladder Cancer Studies
Second Military Medical University
2017-2024
Eastern Hepatobiliary Surgery Hospital
2017-2024
XinHua Hospital
2018-2020
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2017-2018
Wenzhou Medical University
2017-2018
Sun Yat-sen University
2016-2018
The First Affiliated Hospital, Sun Yat-sen University
2016-2018
Fundación Juan March
2017
National Taiwan University Hospital
2008
University of Tokyo Hospital
2008
Adolescent idiopathic scoliosis is the most common spinal disorder in adolescents with a prevalence of 0.5-5.2% worldwide. The traditional methods for screening are easily accessible but require unnecessary referrals and radiography exposure due to their low positive predictive values. application deep learning algorithms has potential reduce costs screening. Here, we developed validated automated using unclothed back images. accuracies were superior those human specialists detecting...
Longer spinal fusions have been shown to result in improved deformity correction; however, loss of normal flexibility the fusion area should not be ignored. Current consensus was achieve a shorter primary surgery, with goal preserving as much distal motion segment possible. However, correlation between length and functional outcome remains controversial. To best our knowledge, previous study has demonstrated function outcomes differences HRQoL specific levels. In this cross-sectional study,...
Of the three unfolded protein response pathways, which are activated by endoplasmic reticulum stress, inositol-requiring enzyme 1α (IRE1α)-X-box-binding 1 (XBP1) signaling is most conserved. These pathways implicated in a variety of types cancer, including hepatocellular carcinoma (HCC). However, role IRE1α-XBP1 development HCC remains unclear. In current study, reverse transcription-quantiative polymerase chain reaction was used to analyze expression levels XBP1 and interleukin (IL)-6 human...
Accumulating evidence suggests that microRNA (miR)-146a functions as an oncogene or tumor suppressor in various cancers. However, the role of miR‑146a gastric cancer (GC) remains to be elucidated. The present study investigated function GC cells. results revealed modulates cell apoptosis. Overexpression significantly increased apoptosis SGC‑7901 cells, whereas inhibition protected cells from expression was inversely correlated with transforming growth factor β‑activated kinase 1 (TAK1)...
Study Design. Retrospective analysis. Objective. To evaluate whether radiologic parameters affect spine surgeon's osteotomy choice in patients with severe and stiff thoracic kyphoscoliosis. Summary of Background Data. Three-column osteotomies were developed to address Current on is based the morphology kyphosis, global balance, locations main curvature; however, quantitative basis for decision making still lacking. Methods. Sixty kyphoscoliosis who underwent three-column classified into four...
To investigate the expression level of microRNA-101-3p (miR-101-3p) and its possible association with progression, prognosis chemotherapy in patients non-small cell lung cancer (NSCLC), Gene Expression Omnibus (GEO) database was used. Quantitative polymerase chain reaction used to verify 327 NSCLC 42 adjacent normal tissues, which viable tissues were paired nearby tissues. Based on Cox regression model, univariate multivariate analyses address factors that had effects overall survival (OS)...
The aim of the present study was to evaluate different expression levels thyroid hormone responsive (THRSP; Spot14)/S14 related, Mig12 (S14R) during bone marrow mesenchymal stem cell (BM-MSC) adipogenesis in adolescent idiopathic scoliosis (AIS) patients. MSCs were retrospectively isolated from AIS patients and controls, adipogenic differentiation induced. Total RNA extracted for Affymetrix 3'‑IVT profiling microarrays compared with results healthy controls. confirmed by semiquantitative...
Background: Dysregulation of microRNAs (miRNAs) in papillary thyroid cancer (PTC) might influence prognosis PTC. This study is aimed to develop a risk score system for predicting Methods: The miRNA and gene expression profiles PTC were obtained from Cancer Genome Atlas database. samples randomly separated into training set (n = 248) validation 248). differentially expressed miRNAs (DE-miRNAs) the screened using limma package. independent prognosis-associated DE-miRNAs identified building...
Proximal junctional kyphosis (PJK) is a common sagittal complication of adolescent idiopathic scoliosis (AIS) after corrective surgery, leading to new deformities, pain, and, even, revision surgery. In the present study, we investigated risk and predictive factors for PJK in patients who had undergone Lenke type 5 AIS correction identify parameters relevant intraoperative guidance. A total 35 with surgery at our hospital from January 2008 February 2016 were divided into (n = 15) non-PJK 20)...
Retrospective study.This study is to measure and analyze the changes of three-dimensional (3D) distances spinal column canal at three-column osteotomy sites address their clinical neurologic significance.Three-column osteotomies were developed treat severe stiff spine deformities with insufficient understanding on safe limit shortening relationship between distance that canal.Records 52 continuous patients scoliosis treated our institution from July 2013 June 2015 reviewed. The preoperative...
Extracellular matrix metalloproteinase inducer (EMMPRIN) has been reported to be associated with tumor formation and invasion in many studies. However, the clinicopathological significance prognosis of EMMPRIN cancer patients remains inconclusive. Therefore, we conducted a meta-analysis assess predictive potential various cancers. By searching Pubmed, Cochrane library database web science comprehensively, 39studies 5739 cases were included our meta-analysis. The results indicated that...
Laparoscopy-assisted gastrectomy (LAG) is a minimally invasive procedure for the treatment of gastric cancer. It generally thought that technique results in less visible blood loss during surgery. Nevertheless, meaningful perioperative hidden (HBL) often ignored. In this study, we investigated amount HBL and influential factors after LAG cancer.A retrospectively analyzed clinical data 62 consecutive patients who underwent laparoscopy-assisted total or distal at our center from May 2016 to...
Single-stage spine-shortening osteotomy without treating spinal cord malformations may have potential advantages for the treatment of severe congenital scoliosis (CS) with type I split malformation (SSCM); however, study this technique was limited.To evaluate safety and efficacy a single-stage in CS associated SSCM.A retrospective designed to compare 2 case series including 12 patients SSCM 26 A function (without malformations, evoked abnormalities, neurological dysfunctions preoperatively)...
STUDY DESIGN: A retrospective study in Chinese Han people. PURPOSE: To explore whether promoter polymorphisms of matrix metalloproteinases-3 (MMP-3) (rs3025058) and interleukin-6(IL-6) (rs1800795) genes are associated to AIS gender bias. METHODS:
Water-soluble vitamins play essential roles in normal body functions and metabolic activities. However, few methods have simultaneously measured all nine water-soluble biological matrices. In this study, we developed a sensitive accurate method for the simultaneous measurement of thiamine (B1), riboflavin (B2), nicotinamide (B3), pantothenic acid (B5), 4-pyridoxic (B6), biotin (B7), 5-methyltetrahydrofolic (B9), ascorbic (VC), methylmalonic (MMA) human serum. Samples were analyzed using...
Purpose: To establish a computed tomography–based prognostic model for patients with hepatocellular carcinoma treated transarterial chemoembolization. Materials and Methods: Using prospectively collected data from 195 consecutive who underwent chemolipiodolization at the Eastern Hepatobiliary Surgery Hospital between 2013 2016, we established based on enhancement patterns tomography scans to predict outcome of Furthermore, histopathology analysis was performed 108 different undergoing...
Positive retests of COVID-19 represent a public health concern because the increased risk transmission. This study explored whether factors other than nucleic acid amplification test (NAAT) contribute to positive retest results. Patients with admitted Guanggu district Hubei Maternal and Child Health Hospital between February 17 March 28, 2020, were retrospectively included. The patients grouped into negative (n = 133) 51) groups. results showed that proportion presenting cough was higher (P...