A5068473177- MicroRNA in disease regulation
- Circular RNAs in diseases
- Spinal Fractures and Fixation Techniques
- Pelvic and Acetabular Injuries
- Spine and Intervertebral Disc Pathology
- Meningioma and schwannoma management
- Pain Mechanisms and Treatments
- Fatigue and fracture mechanics
- Medicinal Plant Pharmacodynamics Research
- Ion Channels and Receptors
- Intraoperative Neuromonitoring and Anesthetic Effects
- Cancer-related molecular mechanisms research
- Connective tissue disorders research
- Renal and related cancers
- RNA Research and Splicing
- Natural product bioactivities and synthesis
- Genetic factors in colorectal cancer
- Heat shock proteins research
- Caveolin-1 and cellular processes
- Scoliosis diagnosis and treatment
- Cancer Treatment and Pharmacology
Sun Yat-sen University
2011-2022
Eighth Affiliated Hospital of Sun Yat-sen University
2021-2022
The First Affiliated Hospital, Sun Yat-sen University
2011-2021
The Seventh Affiliated Hospital of Sun Yat-sen University
2020
Circular RNA (circRNA) is related to many human diseases including osteoarthritis (OA). Our research purpose was show that functional circRNAs have a role in the pathogenesis of OA, while also identifying potential circRNA bind miRNA-27b-3p. Microarray analysis used evaluate expression CircRNA OA and normal cartilage. The mechanism Circ_0000423 up-regulation were detected verified vitro vivo. transfection, qRT-PCR, Western blot analysis, immunofluorescence, dual-luciferase assays investigate...
Circular RNAs (circRNAs) play a key role in regulating the tumorigenesis and development of human cancers, including osteosarcoma (OS). Of note, molecular mechanism underlying progression OS has remained largely unclear. The present study identified that novel circRNA circEIF4G2 was upregulated tissues cells. Moreover, we constructed circEIF4G2‐mediated ceRNA network revealed involved multiple cancer pathways, such as EGFR signaling pathway, PI3K‐Akt ErbB pathway. Loss‐of‐function assays...
Paclitaxel-induced peripheral neuropathic pain (PIPNP) is a major therapy- and dose-limiting side effect that extremely laborious to treat. Resveratrol (Res), with structure name of 3,5,40-trihydroxystilbene, kind natural polyphenolic chemical plenty useful characteristics such as anti-inflammatory, anti-oxidative stress. However, the impact Res on PIPNP remains unclear. Therefore, current study intends examine analgesic PIPNP. In present study, results revealed could effectively prevent...
G2 and S phase-expressed-1 (GTSE1) negatively regulates the tumor-suppressive protein p53 is potentially correlated with chemoresistance of cancer cells. This study aims to explore effect GTSE1 on DNA damage repair cisplatin (CDDP) resistance in osteosarcoma (OS).Expression OS was predicted bioinformatics system GEPIA then validated clinically obtained tissues acquired cell lines using RT-qPCR, immunohistochemical staining, western blot assays. Gain- loss-of-function studies were performed...
Glioblastoma multiforme (GBM) is the most common type of primary brain tumour in adults, and presents a very low survival rate. Isocitrate dehydrogenase (IDH)1/2 mutations have been found ~12% glioblastomas are associated with long‑term GBM survival. However, risk factors that influence prognosis IDH‑wild remain unclear. Hypoxia‑inducible factor (HIF)‑1α, an important oxygen‑regulated transcription factor, has demonstrated to serve crucial role development be poor prognosis. In addition,...
Osteosarcoma (OS) is the most common primary malignancy of bone with a high incidence in children. Circular RNAs (circRNAs) play crucial roles carcinogenesis and chemoresistance OS. In current work, we focused on function mechanism hsa_circ_0003496 (circ_0003496) OS progression chemoresistance. The expression levels circ_0003496, miR-370 Krüppel-like factor 12 (KLF12) mRNA were measured by quantitative real-time polymerase chain reaction (qRT-PCR). Cell Counting Kit-8 (CCK-8) assay was used...
The aim of the present study was to evaluate different expression levels thyroid hormone responsive (THRSP; Spot14)/S14 related, Mig12 (S14R) during bone marrow mesenchymal stem cell (BM-MSC) adipogenesis in adolescent idiopathic scoliosis (AIS) patients. MSCs were retrospectively isolated from AIS patients and controls, adipogenic differentiation induced. Total RNA extracted for Affymetrix 3'‑IVT profiling microarrays compared with results healthy controls. confirmed by semiquantitative...
Inflammation and insomnia are medical problems that may severely affect work health, thereby necessitating strategies for their effective treatment. Icartin (ICT) is a major active monomeric component of icariin . Studies have revealed ICT possesses several pharmacological properties such anti-inflammatory, anti-tumor, anti-fibrotic, anti-osteoporotic neuroprotective effects. The present research was carried out to investigate the analgesic sedative/hypnotic effects ICT. results obtained...
Objective To study the surgical indications and effectiveness of short segment pedicle screw fixation plus pecutaneous vertebroplasty (PVP) for single thoracolumbar fracture combined with Kummell disease. Methods Between June 2012 2014, a prospective case series analysis was made on clinical data 15 selected cases patients who were disease. There three males 12 females, an average age 62.5 years(range, 48-80 years). The injured vertebrae located at T11in 3 cases, T12in 4, L1 in 5 L2...