A5036942545- Viral Infections and Immunology Research
- Systemic Lupus Erythematosus Research
- MicroRNA in disease regulation
- Virus-based gene therapy research
- Aquaculture disease management and microbiota
- Vitamin D Research Studies
- RNA regulation and disease
- Cancer-related molecular mechanisms research
- Immune Response and Inflammation
- Cytokine Signaling Pathways and Interactions
- Autism Spectrum Disorder Research
- Respiratory viral infections research
- Aquaculture Nutrition and Growth
- Plant Parasitism and Resistance
- Physiological and biochemical adaptations
- Cytomegalovirus and herpesvirus research
- Atherosclerosis and Cardiovascular Diseases
- Plant and animal studies
- Inflammasome and immune disorders
- Histone Deacetylase Inhibitors Research
- Herpesvirus Infections and Treatments
- Plant Reproductive Biology
- interferon and immune responses
- Ubiquitin and proteasome pathways
- Whipple's Disease and Interleukins
Hainan Maternal and Child Health Hospital
2013-2024
Anhui Medical University
2024
Xinjiang Production and Construction Corps
2011-2023
Hainan Medical University
2021-2023
Children's Hospital of Fudan University
2022
Hunan Academy of Agricultural Sciences
2022
Eighth Affiliated Hospital of Sun Yat-sen University
2021
Sun Yat-sen University
2021
Army Medical University
2021
The First People's Hospital of Changzhou
2019
Recent literatures indicate that maternal hormone exposure is a risk factor for autism spectrum disorder (ASD). We hypothesize prenatal progestin may counteract the neuroprotective effect of estrogen and contribute to ASD development, we aim develop method ameliorate exposure-induced autism-like behavior. Experiment 1: Prenatal offspring are treated with resveratrol (RSV) through either or postnatal then used behavior testing other biomedical analyses. 2: norethindrone (NET) ERβ knockdown...
Background: 5-aza-2'-deoxycytidine (5Aza), a DNA methyltransferase (DNMT) inhibitor, could activate tumor adaptive immunity to inhibit progression. However, the molecular mechanisms by which 5Aza regulates immune microenvironment are still not fully understood. Methods: The role of in peritoneal carcinomatosis (PC) colorectal cancer (CRC) was investigated. effects on macrophage activation were studied flow cytometry, real-time PCR, Western blotting assays, and Drug Affinity Responsive Target...
We have previously reported that prenatal progestin exposure induces autism-like behavior in offspring through ERβ (estrogen receptor β) suppression the brain, indicating may induce autism spectrum disorders (ASD). In this study, we aim to investigate whether is associated with ASD. A population-based case-control epidemiology study was conducted Hainan province of China. The ASD children were first screened Autism Behavior Checklist (ABC) questionnaire, and then diagnosed by clinical...
Acute myeloid leukemia (AML) is a heterogeneous disorder of the hematopoietic system with no common genetic "Achilles heel" that can be targeted. Most patients respond well to standard therapy, while majority relapse, and development an effective therapy for AML still urgently needed. In this study, we demonstrated betulinic acid (BA) significantly increased Aryl hydrocarbon receptor (AHR) expression through demethylation on AHR promoter in cells, interacts sequesters ARNT, subsequently...
Multiple myeloma (MM) is an incurable hematologic malignancy due to inevitable relapse and chemoresistance development. Our preliminary data show that MM cells express high levels of PGC1β LDHA. In this study, we investigated the mechanism behind PGC1β-mediated LDHA expression its contribution tumorigenesis, aid in development novel therapeutic approaches for MM. Real-time PCR western blotting were first used evaluate gene different cells, then, luciferase reporter assay, chromatin...
Gambogic acid (GA) is the main active ingredient of resin gamboges and possesses anti-cancer activity toward various human cancer cells. However, clinical application GA has been limited by its poor aqueous solubility dose-limiting toxicities. Cell-penetrating peptides (CPPs) are widely used to deliver drugs into cells enhance water drugs.The object this study was synthesize peptide-drug conjugates in which cell-penetrating peptide TAT (trans-activator transcription) conjugated evaluated...
Domestication has altered a variety of traits within the Eurasian perch (Perca fluviatilis), including phenotypic, physiological and behavioral fluviatilis). Little is known, however, about genetic changes between domesticated wild perch. In this study, we assembled high-quality de novo reference transcriptome identified differentially expressed genes A total 113,709 transcripts were assembled, 58,380 annotated. Transcriptomic comparison revealed 630 Within there 412 that up-regulated MHCI,...
Abstract This study aims to explore effects of 1,25( OH ) 2 D 3 and vitamin receptor ( VDR on peripheral CD 4 + / 8 double‐positive (DP) T lymphocytes in systemic lupus erythematosus SLE ). MRL ‐ LP r/ r mice with n = 20) normal were assigned into the control group (normal mice, without feeding ), ‐knock‐in ‐knock‐in, ‐knockout ‐knockout, 10 per group). Levels measured by flow cytometry. The mRNA proteins expressions inflammatory factors qRT PCR ELISA . Extracellular signal‐regulated...
The current study was conducted with the central objective of investigating expression microRNA-145 (miR-145) in renal vascular lesions (RVLs) juvenile lupus nephritis (JLN) and its possible mechanism.The clinical data 49 JLN patients confirmed by biopsy were collected followed grouping according to RVLs score after hematoxylin-eosin staining: mild, moderate, severe groups. In situ hybridization used detect miR-145 vessels which then being compared among different Up-LV-miR-145 LV-miR-NC...
Aggravated endoplasmic reticulum stress (ERS) and apoptosis in podocytes play an important role lupus nephritis (LN) progression, but its mechanism is still unclear. Herein, the of SMURF1 regulating ERS during LN progression were investigated. MRL/lpr mice was used as model vivo. HE staining performed to analyze histopathological changes. Mouse (MPC5 cells) treated with serum IgG from patients (LN-IgG) construct vitro. CCK8 assay adopted determine viability. Cell measured using flow...
To investigate clinical and neuroimaging features of enterovirus71 (EV71) related acute flaccid paralysis in patients with hand-foot-mouth disease. Nine met the criterion EV71 induced disease underwent spinal brain MR imaging from May 2008 to Sep 2012. One extremity was found four cases (3 lower limb, 1 upper limb), two limbs three (2 limbs, limbs), cases. Spinal MRI studies showed lesion high signal T2-weighted images (T2WI) low T1-weighted (T1WI) cord all nine cases, lesions were mainly...
Paclitaxel-induced peripheral neuropathic pain (PIPNP) is a major therapy- and dose-limiting side effect that extremely laborious to treat. Resveratrol (Res), with structure name of 3,5,40-trihydroxystilbene, kind natural polyphenolic chemical plenty useful characteristics such as anti-inflammatory, anti-oxidative stress. However, the impact Res on PIPNP remains unclear. Therefore, current study intends examine analgesic PIPNP. In present study, results revealed could effectively prevent...
Plasmacytoid dendritic cells (pDCs) play a key role in the initiation and amplification of systemic lupus erythematosus (SLE)-associated vascular injury. In this study, we found that dsDNA induced dose- time-dependent increase IFN-α Toll-like receptor 7 (TLR7), TLR9 IRF7 expression pDCs. Co-cultured circulating endothelial (ECs) with activated pDCs significantly decreased proliferation, tube formation migration ECs. The elevated level cellular increased cell adhesion, promoted apoptosis,...
Abstract Objective Long noncoding RNA (lncRNA) taurine upregulated gene 1 (TUG1) is increased under the condition of ischemia. This study intended to identify mechanism TUG1 in renal ischemia-reperfusion (I/R). Methods First, a rat model acute injury induced by I/R was established, followed measurement blood urea nitrogen (BUN), serum creatine (SCr), methylenedioxyphetamine (MDA) and superoxide dismutase (SOD) rats. knocked down rats (ko-TUG1 group). Next, histological staining used evaluate...